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41.
Yasri A Berthelot D Gijsen H Thielemans T Marichal P Engels M Hoflack J 《Journal of chemical information and computer sciences》2004,44(6):2199-2206
REALISIS is a software system for reagent selection, library design, and profiling, developed to fit the workflow of bench chemists and medicinal chemists. Designed to be portable, the software offers a comprehensive graphical user interface and rapid, integrated functionalities required for reagent retrieval and filtering, product enumeration, and library profiling. REALISIS is component-based, consisting of four main modules: reagent searching; reagent filtering; library enumeration; and library profiling. Each module allows the chemist to access specific functionalities and diverse filtering and profiling mechanisms. By implementing the entire process of reagent selection, library design, and profiling and by integrating all the necessary functionalities for this process, REALISIS cuts the time required to design combinatorial and noncombinatorial libraries from several days to a few hours. 相似文献
42.
Phenyl-substituted ethenes react with iodine and xenon difluoride to provide difluorinated products. Iodofluoro intermediates react with xenon difluoride to produce transient iodine difluoride species that lose IF and F(-) and produce carbocations. 相似文献
43.
Activation of CO2 at Transition Metal Centres: The Route of the CO2 Reduction at Nikel(0) Moieties A competing reaction in the catalytic cyclooligomerization of hex-3-yne and CO2 at the (TMED)Ni(0)-fragment (TMED = N,N,N′,N′-tetramethylethylendiamine) is the formation of carbon monoxide and (TMED)Ni(CO3). So it is possible to explain the generation of II (TMED)Ni(diethylmalicacidanhydride) and III (a nickel trimer with two (TMED)Ni(CO3) units). Both complexes are characterized by X-ray analysis. The reduction of CO2 to CO most likely proceeds via an intermediate in which two molecules of carbon dioxide are coupled head-to-tail to form a metallacycle. An ab initio scf geometry optimization supports the existence of such an intermediate. 相似文献
44.
Catalytic enantioselective synthesis of beta-amino acid derivatives is an area of intense interest, due to the importance of these compounds as components in pharmaceutical agents and peptidomimetics. In this report, we present the first catalytic enantioselective method for the synthesis of gamma-unsaturated beta-amino acids and their corresponding 1,3-amino alcohol derivatives. This methodology takes advantage of a highly enantioselective vinylzinc addition to an aldehyde to set chirality. The resulting allylic alcohols are then transformed into the corresponding allylic amines via Overman's [3,3]-sigmatropic imidate rearrangement, and subsequent one-pot deprotection-oxidation of a pendant oxygen leads to the gamma-unsaturated beta-amino acid derivatives of high enantiopurity. 相似文献
45.
Waterman PR Overhaus M Heckenkamp J Nigri GR Fungaloi PF Landis ME Kossodo SC LaMuraglia GM 《Photochemistry and photobiology》2002,75(1):46-50
Restenosis results from intimal hyperplasia and constrictive remodeling following cardiovascular interventions. Photodynamic therapy (PDT) has been shown to inhibit intimal hyperplasia in vivo by preventing neointimal repopulation of the treated vessel. This study was undertaken in an attempt to further dissect the mechanisms by which PDT acts on secreted and extracellular matrix proteins to inhibit migration of cultured human vascular cells. PDT of three-dimensional collagen gels inhibited invasive human smooth muscle cell (SMC) migration, whereas cell-derived matrix metalloproteinase production remained unaltered. Additionally, PDT generated cross-links in the collagen gels, a result substantiated in an ex vivo model whereby PDT rendered the treated vessels resistant to pepsin digestion and inhibited invasive migration of SMC and fibroblasts. These data support the premise that by inducing matrix protein cross-links, rendering the vessel resistant to degradation, in vivo PDT inhibits repopulation of the vessel and therefore intimal hyperplasia. 相似文献
46.
Studies of the preparation of 1,8-dihydroazocines and transannular cyclization of hydroazocines to produce functionalized pyrrolizidines are described. Results are presented which demonstrate that unsymmetrically substituted acetylenes bearing at least one electron withdrawing groups undergo efficient cycloaddition to 1 - β - styryl - 1,2 - dihydropyridine producing in a regio-selective fashion 3,4 - disubstituted - 1,8 - dihydroazocines. The dihydroazocines generated in this manner can be converted to 1 - formyl - Δ4,5 - epoxyazocines which undergo interesting rearrangement reactions to form pyrrolizidines when subjected to methoxide deformylation followed by acid treatment. In addition, 1,6,7,8 - tetrahydroazocines can be converted to pyrrolizidines under bromination conditions. The intriguing chemical process which occur under the conditions outlined above are described. 相似文献
47.
Analyte transfer from the matrix in a thin layer distillation (TLD) cell and its subsequent measurement were investigated in a flow injection configuration. We designed the cell such that the donor and acceptor streams flowed in parallel channels separated by a thin dividing wall. The matrix transfer process involved room-temperature distillation of the analyte into the headspace of the TLD cell and its subsequent condensation/uptake by a concurrently flowing acceptor stream. There are no membranes; hence there are no membrane-related problems. The TLD system design was optimized with respect to its dimensions and operational parameters. Throughput and sensitivity were compared with a conventional pervaporation flow injection (PFI) system for ammonia and five different amines. For the higher molecular mass amines, the TLD approach provided comparable or superior performance. The TLD technique should be an attractive approach for online analysis of volatile chemical species in ‘dirty’ samples, especially for volatile analytes of higher molecular mass. 相似文献
48.
Monovalent cations play an important role in many biological functions. The guanine rich sequence, d(G4T4G4), requires monovalent cations for formation of the G-quadruplex, d(G4T4G4)2. This requirement can be satisfied by thallium (Tl+), a potassium (K+) surrogate. To verify that the structure of d(G4T4G4)2 in the presence of Tl+ is similar to the K+-form of the G-quadruplex, the solution structure of the Tl+-form of d(G4T4G4)2 was determined. The 10 lowest energy structures have an all atom RMSD of 0.76 +/- 0.16 A. Comparison of this structure to the identical G-quadruplex formed in the presence of K+ validates the isomorphous nature of Tl+ and K+. Using a 1H-205Tl spin-echo difference experiment we show that, in the Tl+-form of d(G4T4G4)2, small scalar couplings (<1 Hz) exist between 205Tl and protons in the G-quadruplex. These data comprise the first 1H-205Tl scalar couplings observed in a biological system and have the potential to provide important constraints for structure determination. These experiments can be applied to any system in which the substituted Tl+ cations are in slow exchange with the bulk ions in solution. 相似文献
49.
The concept of a Born–Oppenheimer (BO) potential energy surface (PES) has been extended to non-adiabatic wavefunctions by Hunter and by Wilson. A Hunter non-adiabatic PES corresponding to an excited vibrational state has a set of spikes superimposed on a BO-like PES. It was believed that Wilson PESs were spike-free. We show that it is not the case and that the Wilson PES value at a given nuclear configuration is not the expectation value of a quantum observable but a quotient of such expectation values. Consequently, BO PESs have the quantum interpretation of quotients of approximate expectation values of observables. 相似文献
50.
Brahim Lakhrissi Mohamed Massoui El Mokhtar Essassi Vincent Lequart Nicolas Joly Patrick Martin Grard Goethals 《Journal of heterocyclic chemistry》2004,41(6):1011-1014
Reaction of 1,5‐benzodiazepin‐2,4‐dione with 3‐O‐substituted‐5,6‐anhydro‐1,2‐isopropylidene‐α‐D‐glucofuranose gave the unexpected N,N'‐di‐glucofuranosyl benzimidazol‐2‐one by a novel rearrangement and ring closure reaction. A mechanism is proposed. 相似文献