MRI contrast-dose relationship of manganese(III)tetra(4-sulfonatophenyl) porphyrin with human xenograft tumors in nude mice at 2.0 T

Previously we reported that Mn(III)tetra(4-sulfonatophenyl) porphyrin, MnTPPS₄, is a contrast agent which can effectively enhance tumor detection by MRI. By imaging 30 additional athymic nude mice bearing subcutaneous MCF-7 WT human breast carcinoma xenografts, we have extended dose-contrast relationships over a wide range of intraperitoneal (IP) doses ranging from 0.025 to 0.50 mmol/kg. The benefits of IP injection are higher possible doses on a volume basis and a reduction in toxicity versus IV administration. Full coronal cross-section images have been obtained on a 2-T spectrometer. Although individual tumor masses displayed different distribution patterns, reflective of their internal morphology, single doses of 0.10 mmol/kg or greater were necessary to produce a detectable effect. At a dose of 0.50 mmol/kg, marked enhancement was produced. Multiple small dosages administered over the course of several days before imaging did not produce increased enhancement. Preliminary results on the new porphyrin derivative, MnTPPS₃, indicate that the ratio of the toxic dose to the effective dose may be adjustable to render this class of agents clinically useful.     

Towards molecular-scale electronics and biomolecular self-assembly

This paper provides an overview of recent research developments in the field of nanoelectronics with organic materials such as carbon nanotubes and DNA-templated nanowires. Carbon nanotubes and gold electrodes are chemically functionalized in order to contact carbon nanotubes by self-assembly. The transport properties of these nanotubes are dominated by charging effects and display clear Coulomb blockade behaviour. A different approach towards nanoscale electronics is based on the molecular recognition properties of biomolecules such as DNA. As an example, DNA is stretched between electrodes using a molecular combing technique. A two-step metallization procedure leads to the formation of highly conductive gold nanowires.     

Toward an ideal integrating nephelometer

The Integrating Sphere Integrating Nephelometer is a novel and unique reciprocal nephelometer that uses an integrating sphere with attached truncation-reduction tubes to contain the sample volume and to integrate the scattered light. Its main advantage compared with current integrating nephelometers is a sevenfold reduction in truncation angle, which reduces errors in measured scattering from large particles. Additional features include improved sampling efficiency for large particles and a well-defined operating wavelength.     

Aspects of Generic Entanglement

We study entanglement and other correlation properties of random states in high-dimensional bipartite systems. These correlations are quantified by parameters that are subject to the ``concentration of measure' phenomenon, meaning that on a large-probability set these parameters are close to their expectation. For the entropy of entanglement, this has the counterintuitive consequence that there exist large subspaces in which all pure states are close to maximally entangled. This, in turn, implies the existence of mixed states with entanglement of formation near that of a maximally entangled state, but with negligible quantum mutual information and, therefore, negligible distillable entanglement, secret key, and common randomness. It also implies a very strong locking effect for the entanglement of formation: its value can jump from maximal to near zero by tracing over a number of qubits negligible compared to the size of the total system. Furthermore, such properties are generic. Similar phenomena are observed for random multiparty states, leading us to speculate on the possibility that the theory of entanglement is much simplified when restricted to asymptotically generic states. Further consequences of our results include a complete derandomization of the protocol for universal superdense coding of quantum states.     

Angular Multiplexing Gratings Characterization in Dichromated Gelatin and Thoughts on Diffractive Optical Memory

We were mainly concerned here with multiple exposure gratings that allow interactions and coupling between gratings. We started the study of interactions and coupling with five gratings recorded in dichromated gelatin (DCG). Having determined experimentally the characteristic parameters of these five gratings, we used a method developed by Oxford University to synthesize the modulation profile. Entering these parameters of each grating into our computing programs (based on the alternative theory of diffraction in modulated media) and by varying the amplitude modulation, the latter was deduced by adjusting the numerical curve to the experimental one. We then extended the study to nine multiplexed gratings. This study allowed us to know the range of the amplitude modulation such that a certain number of angular multiplexing can be done in DCG. Several undesirable effects which we had experimentally observed appeared then during the reconstruction of any one of the multiplexed images, such as cross-talk effect. We noted the good concordance between experimental and theoretical results. We finally illustrated cross-talk effect in a diffractive memory where, if the amplitude modulation was first calculated, the number of multiplexing for an angular range could then be determined and the angular separation achieved to avoid cross-talk.     

Optical clock distribution for multichip module

We propose an optical H-tree structure to distribute a clock signal onto 16 electronic chips at 1 Gb/s for a clock skew and timing jitter of less than 100 ps. Fabrication steps and performance results are presented.     

Ultrahigh-sensitivity fiber-optic strain and temperature sensor

We report ultrahigh-sensitivity static strain sensing (noise equivalent strain 相似文献   

CTV Based Sensor for the Rapid Detection of Nitro Toluene With Computational Studies and Molecular Modelling

Journal of Fluorescence - A new tri-naphthoylated Cyclotriveratrylene molecule has been synthesized for the rapid and sensitive detection of 4-nitrotoluene (4-NT) among various nitro aromatic...