排序方式: 共有31条查询结果,搜索用时 31 毫秒
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Kerru Nagaraju Bhaskaruni Sandeep V. H. S. Gummidi Lalitha Maddila Surya Narayana Singh Parvesh Jonnalagadda Sreekantha B. 《Molecular diversity》2020,24(2):345-354
Molecular Diversity - The Bi2O3 loading on ZrO2 as heterogeneous catalyst was established as an extremely efficient catalyst for the synthesis of a series of novel... 相似文献
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Molecular Diversity - Antimicrobial resistance has become a significant threat to global public health, thus precipitating an exigent need for new drugs with improved therapeutic efficacy. In this... 相似文献
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Parvesh Singh 《Tetrahedron》2006,62(48):11267-11273
A facile single step synthesis of novel azocinone derivatives involving tandem [2+2] cycloaddition and Cope rearrangement in the reactions of cross-conjugated azatrienes with vinyl/isopropenyl ketenes supported by theoretical calculations is reported. 相似文献
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Parvesh Gangwani Ravneet Kaur Sujata Pandey Subhasis Haldar Mridula Gupta R.S. Gupta 《Superlattices and Microstructures》2008
The paper presents an accurate charge control model for a fully strained (FS), and partially relaxed (PR) lattice mismatched AlGaN/GaN HEMT, taking into consideration the effect of spontaneous and piezoelectric polarization. The model also accounts for the mobility degradation with increase in temperature, which is one of the major causes in deterioration of the driving current. By using the variation of band gap with temperature, the temperature dependence on threshold voltage, sheet carrier concentration and drain current is studied. Further, the temperature variation shows the applicability of the device in a variable thermal environment. A close agreement of calculated data with simulated/experimental data proves the validity of the model. 相似文献
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Glaser RW Sachse C Dürr UH Wadhwani P Ulrich AS 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2004,168(1):153-163
A highly sensitive solid state (19)F-NMR strategy is described to determine the orientation and dynamics of membrane-associated peptides from specific fluorine labels. Several analogues of the antimicrobial peptide PGLa were synthesized with the non-natural amino acid 4-trifluoromethyl-phenylglycine (CF(3)-Phg) at different positions throughout the alpha-helical peptide chain. A simple 1-pulse (19)F experiment allows the simultaneous measurement of both the anisotropic chemical shift and the homonuclear dipolar coupling within the rotating CF(3)-group in a macroscopically oriented membrane sample. The value and sign of the dipolar splitting determines the tilt of the CF(3)-rotational axis, which is rigidly attached to the peptide backbone, with respect to the external magnetic field direction. Using four CF(3)-labeled peptide analogues (with L-CF(3)-Phg at Ile9, Ala10, Ile13, and Ala14) we confirmed that PGLa is aligned at the surface of lipid membranes with its helix axis perpendicular to the bilayer normal at a peptide:lipid ratio of 1:200. We also determined the azimuthal rotation angle of the helix, which agrees well with the orientation expected from its amphiphilic character. Peptide analogues with a D-CF(3)-Phg label resulting from racemization of the amino acid during synthesis were separately collected by HPLC. Their spectra provide additional information about the PGLa structure and orientation but allow only to discriminate qualitatively between multiple solutions. The structural and functional characterization of the individual CF(3)-labeled peptides by circular dichroism and antimicrobial assays showed only small effects for our four substitutions on the hydrophobic face of the helix, but a significant disturbance was observed in a fifth analogue where Ala8 on the hydrophilic face had been replaced. Even though the hydrophobic CF(3)-Phg side chain cannot be utilized in all positions, it allows highly sensitive NMR measurements over a wide range of experimental conditions and dynamic regimes of the peptide. 相似文献
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Rakesh Kumar Mahajan Pallavi Sood Mohinder Pal Mahajan Parvesh Singh 《Analytical sciences》2004,20(10):1423-1426
A silver ion-selective electrode was prepared with a polymeric membrane incorporating 2,6-bis-methylsulfanyl-[1,3,5]thiadiazine-4-thione as an ionophore, tri-n-butylphosphate (TBP) as a plasticizer and sodium tetraphenylborate (NaTPB) as an additive. The electrode exhibited a near-Nernstian response of 52 mV/decade over a wide linear concentration range of 1.0 x 10(-5) - 1.0 x 10(-1) M with a lower detection limit of 9.77 x 10(-6) M. The electrode exhibited excellent selectivity for silver ion over many of the alkali, alkaline-earth and transition metal ions. The electrode worked well over a wide pH range of 1.77 - 7.13. The response time of the electrode was less than 20 s. The sensor can be applied as indicator electrode for the potentiometric titration of Ag+ ions with Cl- ions. 相似文献
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Preferential uptake of L- versus D-amino acid cell-penetrating peptides in a cell type-dependent manner 总被引:1,自引:0,他引:1
Verdurmen WP Bovee-Geurts PH Wadhwani P Ulrich AS Hällbrink M van Kuppevelt TH Brock R 《Chemistry & biology》2011,18(8):1000-1010
The use of protease-resistant D-peptides is a prominent strategy for overcoming proteolytic sensitivity in the use of cell-penetrating peptides (CPPs) as delivery vectors. So far, no major differences have been reported for the uptake of L- and D-peptides. Here we report that cationic L-CPPs are taken up more efficiently than their D-counterparts in MC57 fibrosarcoma and HeLa cells but not in Jurkat T leukemia cells. Reduced uptake of D-peptides co-occurred with persistent binding to heparan sulfates (HS) at the plasma membrane. In?vitro binding studies of L- and D-peptides with HS indicated similar binding affinities. Our results identify two key events in the uptake of CPPs: binding to HS chains and the initiation of internalization. Only the second event depends on the chirality of the CPP. This knowledge may be exploited for a stereochemistry-dependent preferential targeting of cells. 相似文献
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Branham ML Singh P Bisetty K Sabela M Govender T 《Molecules (Basel, Switzerland)》2011,16(12):10269-10291
This study reports the synthesis and characterization of novel ruthenium (II) complexes with the polydentate dipeptide, L-carnosine (2-[(3-aminopropanoyl)amino]-3-(1H-imidazol-5-yl)propanoic acid). Mixed-ligand complexes with the general composition [ML(p)(Cl)(q)(H?O)(r)]·xH?O (M = Ru(II); L = L-carnosine; p = 3 - q; r = 0-1; and x = 1-3) were prepared by refluxing aqueous solutions of the ligand with equimolar amounts of ruthenium chloride (black-alpha form) at 60 °C for 36 h. Physical properties of the complexes were characterized by elemental analysis, DSC/TGA, and cyclic voltammetry. The molecular structures of the complexes were elucidated using UV-Vis, ATR-IR, and heteronuclear NMR spectroscopy, then confirmed by density function theory (DFT) calculations at the B3LYP/LANL2DZ level. Two-dimensional NMR experiments (1H COSY, 13C gHMBC, and 1?N gHMBC) were also conducted for the assignment of chemical shifts and calculation of relative coordination-induced shifts (RCIS) by the complex formed. According to our results, the most probable coordination geometries of ruthenium in these compounds involve nitrogen (N1) from the imidazole ring and an oxygen atom from the carboxylic acid group of the ligand as donor atoms. Additional thermogravimetric and electrochemical data suggest that while the tetrahedral-monomer or octahedral-dimer are both possible structures of the formed complexes, the metal in either structure occurs in the 2? oxidation state. Resulting RCIS values indicate that the amide-carbonyl, and the amino-terminus of the dipeptide are not involved in chelation and these observations correlate well with theoretical shift predictions by DFT. 相似文献