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排序方式: 共有188条查询结果,搜索用时 843 毫秒
41.
Adler J Becker JJ Blaylock GT Bolton T Brown JS Bunnell KO Burnett TH Cassell RE Coffman D Cook V Coward DH Dorfan DE Dubois GP Duncan AL Eigen G Einsweiler KF Eisenstein BI Freese T Gladding G Grab C Grancagnolo F Hamilton RP Hauser J Heusch CA Hitlin DG Izen JM Köpke L Li A Lockman WS Mallik U Matthews CG Mir R Mockett PM Mozley RF Nemati B Odian A Parrish L Partridge R Perrier J Pitman D Plaetzer SA Richman JD Sadrozinski HF Scarlatella M Schalk TL Schindler RH Seiden A Simopoulos C 《Physical review letters》1988,60(2):89-92
42.
Bolton T Brown JS Bunnell KO Burchell M Burnett TH Cassell RE Coffman D Coward DH Coyle P DeJongh F Drinkard J Dubois GP Eigen G Eisenstein BI Freese T Gatto C Gladding G Heusch CA Hitlin DG Izen JM Kim PC Labs J Li A Lockman WS Mallik U Matthews CG Mir R Mockett PM Odian A Parrish L Pitman D Richman JD Sadrozinski HF Scarlatella M Schalk TL Schindler RH Seiden A Stockdale IE Toki W Tripsas B Wang MZ Weinstein AJ Weseler S Willutzki HJ Wisniewski WJ Xu R Zhu Y 《Physical review letters》1992,69(9):1328-1331
43.
Coffman D DeJongh F Dubois GP Eigen G Hitlin DG Matthews CG Richman J Weinstein AJ Wisniewski WJ Zhu Y Bolton T Bunnell KO Cassell RE Coward DH Kim PC Labs J Odian A Pitman D Schindler RH Toki W Wasserbaech S Drinkard JJ Gatto C Heusch CA Lockman WS Sadrozinski HF Scarlatella M Schalk TL Seiden A Xu R Eisenstein BI Freese T Gladding G Izen JM Stockdale IE Tripsas B Mallik U Wang MZ Brown JS Burnett TH Li AD Mir R Mockett PM Nemati B Parrish L Willutzki H 《Physical review letters》1992,68(3):282-285
44.
Bai Z Blaylock GT Bolton T Brient J Browder T Brown JS Bunnell KO Burchell M Burnett TH Cassell RE Coffman D Cook V Coward DH DeJongh F Dorfan DE Drinkard J Dubois GP Eigen G Einsweiler KF Eisenstein BI Freese T Gatto C Gladding G Grab C Hauser J Heusch CA Hitlin DG Izen JM Kim PC Labs J Li A Lockman WS Mallik U Matthews CG Mincer AI Mir R Mockett PM Mozley RF Nemati B Odian A Parrish L Partridge R Pitman D Plaetzer SA Richman JD Sadrozinski HF Scarlatella M Schalk TL Schindler RH Seiden A 《Physical review letters》1990,65(6):686-689
45.
Bai Z Blaylock GT Bolton T Brient JC Browder T Brown JS Bunnell KO Burchell M Burnett TH Cassell RE Coffman D Cook V Coward DH DeJongh F Dorfan DE Drinkard J Dubois GP Eigen G Einsweiler KF Eisenstein BI Freese T Gatto C Gladding G Grab C Hauser J Heusch CA Hitlin DG Izen JM Kim PC Labs J Li A Lockman WS Mallik U Matthews CG Mincer AI Mir R Mockett PM Nemati B Odian A Parrish L Partridge R Pitman D Plaetzer SA Richman JD Sadrozinski HF Scarlatella M Schalk TL Schindler RH Seiden A Simopoulos C 《Physical review letters》1990,65(20):2507-2510
46.
Ding K Lu Y Nikolovska-Coleska Z Qiu S Ding Y Gao W Stuckey J Krajewski K Roller PP Tomita Y Parrish DA Deschamps JR Wang S 《Journal of the American Chemical Society》2005,127(29):10130-10131
A successful structure-based design of a class of non-peptide small-molecule MDM2 inhibitors targeting the p53-MDM2 protein-protein interaction is reported. The most potent compound 1d binds to MDM2 protein with a Ki value of 86 nM and is 18 times more potent than a natural p53 peptide (residues 16-27). Compound 1d is potent in inhibition of cell growth in LNCaP prostate cancer cells with wild-type p53 and shows only a weak activity in PC-3 prostate cancer cells with a deleted p53. Importantly, 1d has a minimal toxicity to normal prostate epithelial cells. Our studies provide a convincing example that structure-based strategy can be employed to design highly potent, non-peptide, cell-permeable, small-molecule inhibitors to target protein-protein interaction, which remains a very challenging area in chemical biology and drug design. 相似文献
47.
Adler J Bai Z Becker JJ Blaylock GT Bolton T Brient J Brown JS Bunnell KO Burchell M Burnett TH Cassell RE Coffman D Cook V Coward DH DeJongh F Dorfan DE Drinkard J Dubois GP Eigen G Einsweiler KF Eisenstein BI Freese T Gatto C Gladding G Grab C Hamilton RP Hauser J Heusch CA Hitlin DG Izen JM Kim PC Köpke L Labs J Li A Lockman WS Mallik U Matthews CG Mincer AI Mir R Mockett PM Nemati B Odian A Parrish L Partridge R Pitman D Plaetzer SA Richman JD Roco M Sadrozinski HF Scarlatella M Schalk TL 《Physical review letters》1989,63(12):1211-1214
48.
Adler J Becker JJ Blaylock GT Bolton T Brient JC Brown JS Bunnell KO Burchell M Burnett TH Cassell RE Coffman D Cook V Coward DH Dorfan DE Drinkard J Dubois GP Duncan AL Eigen G Einsweiler KF Eisenstein BI Freese T Gatto C Gladding G Grab C Hamilton RP Hauser J Heusch CA Hitlin DG Izen JM Köpke L Li A Lockman WS Mallik U Matthews CG Mincer A Mir R Mockett PM Mozley RF Nemati B Odian A Parrish L Partridge R Perrier J Pitman D Plaetzer SA Richman JD Sadrozinski HF Scarlatella M Schalk TL 《Physical review D: Particles and fields》1989,40(11):3788
49.
Adler J Becker JJ Blaylock GT Bolton T Brient JC Brown JS Bunnell KO Burchell M Burnett TH Cassell RE Coffman D Cook V Coward DH DeJongh F Dorfan DE Drinkard J Dubois GP Eigen G Einsweiler KF Eisenstein BI Freese T Gatto C Gladding G Grab C Hamilton RP Hauser J Heusch CA Hitlin DG Izen JM Kim PC Köpke L Li A Lockman WS Mallik U Matthews CG Mincer A Mir R Mockett PM Nemati B Odian A Parrish L Partridge R Pitman D Plaetzer SA Richman JD Sadrozinski HF Scarlatella M Schalk TL Schindler RH Seiden A 《Physical review D: Particles and fields》1989,40(3):906-908
50.
The preparations of polymer-supported dialkylphosphinobiphenyl ligands (3) are reported. A palladium catalyst based on ligand 3a is active for amination and Suzuki reactions using unactivated aryl iodides, bromides, or chlorides. Filtration of the catalyst from the reaction mixture allows for simplified product isolation via an aqueous workup. The resin-bound catalyst can be recycled without additional palladium in both the amination and Suzuki reactions. 相似文献