A New Efficient Commercial Iron Mediated Debromination of Aryl Substituted Vic-Dibromide

Debromination of vic-dibromides with commercially available metallic iron in a methanolic medium affords alkenes and alkynes in excellent yields.     

Demonstration of temperature resilient properties of 2D silicon carbide photonic crystal structures and cavity modes

In this paper, photonic crystal (PhC) based on two dimensional (2D) square and hexagonal lattice periodic arrays of Silicon Carbide (SiC) rods in air structure have been investigated using plane wave expansion (PWE) method. The PhC designs have been optimized for telecommunication wavelength (λ = 1.55 μm) by varying the radius of the rods and lattice constant. The result obtained shows that a photonic band gap (PBG) exists for TE-mode propagation. First, the effect of temperature on the width of the photonic band gap in the 2D SiC PhC structure has been investigated and compared with Silicon (Si) PhC. Further, a cavity has been created in the proposed SiC PhC and carried out temperature resiliency study of the defect modes. The dispersion relation for the TE mode of a point defect A1 cavity for both SiC and Si PhC has been plotted. Quality factor (Q) for both these structures have been calculated using finite difference time domain (FDTD) method and found a maximum Q value of 224 for SiC and 213 for Si PhC cavity structures. These analyses are important for fabricating novel PhC cavity designs that may find application in temperature resilient devices.     

A new recyclable/reusable ionic liquid/LiCl system for Suzuki–Miyaura cross coupling reactions

Suzuki–Miyaura cross coupling reactions of aryl halides with aryl boronic acids were carried out in basic ionic liquids in the presence of lithium chloride as a promoter. The coupling reactions, carried out in the absence of base and ligand, proceed in good to excellent yields with easy product isolation and catalyst recycle.     

Microwave-assisted Pd-catalyzed synthesis of fused steroidal and non-steroidal pyrimidines from β-halo-α,β-unsaturated aldehydes

A Pd-catalyzed protocol has been developed for the synthesis of fused steroidal and non-steroidal pyrimidines from β-halo-α,β-unsaturated aldehydes under microwave irradiation. The β-halo-α,β-unsaturated aldehydes are synthesized from corresponding ketones using Vilsmeier formylation reaction. This synthetic protocol is utilized to synthesize some more novel steroidal pyrimidine derivatives and are currently being evaluated for their biological activities.     

Zinc triflate: a highly efficient reusable catalyst in the synthesis of functionalized quinolines via Friedlander annulation

An environmentally friendly and highly efficient procedure for the preparation of quinolines and fused polycyclic quinolines has been developed by a simple Friedlander annulation reaction of 2-aminoaryl ketone with carbonyl compounds in presence of zinc triflate under microwave irradiation and solvent-free conditions. The reaction also proceeds effectively when In(OTf)₃ was used in lieu of Zn(OTf)₂ as the catalyst. The catalyst can be recovered after the reaction and reused efficiently in subsequent runs.     

Synthesis and Antifungal Activities of Some New 5,7‐Disubstituted[1,2,4]Triazolo[1,5‐a]Pyrimidin‐6‐one Derivatives

Synthesis of a new series of [1,2,4]triazolo[1,5‐a]pyrimidin‐6‐one by [4 + 2]cycloaddition reaction of 3‐benzylidineamino[1,2,4]triazole with monophenyl ketene and diphenyl ketene generated in situ from phenylacetyl chloride and diphenylacetyl chloride in the presence of triethylamine is described. The newly synthesized compounds were also tested for antifungal activities against Rhizoctonia solani and Trichoderma sp.     

Synthesis and conformational studies of novel cyclic peptides constrained into a 3 10 helical structure by a heterochiral D-pro-L-pro dipeptide template

An acyclic tripeptide based on a heterochiral D-pro-L-pro template shows a propensity to exist as a 3(10) helical conformation and can be cyclized, via ring-closing metathesis, to the corresponding cyclic tetrapeptides without disrupting the helical conformations in CDCl(3) as well as in DMSO-d(6) solutions. The detailed conformational studies were carried out by using NMR spectroscopy, X-ray crystallography, molecular dynamic simulations, and circular dichroism spectroscopy.     

Bakers’ yeast-catalyzed reductive cleavage of 3-aryl-2,1-benzisoxazoles and its quaternary salts: an efficient green synthesis of 2-aminobenzophenones

Abstract  

3-Aryl-2,1-benzisoxazoles and its salts underwent reductive cleavage of the N–O bond leading to 2-aminobenzophenones with bakers’ yeast under non-fermenting conditions in aqueous media. The procedure gives excellent yields of 2-alkylamino- and 2-aminobenzophenones.     

KF/Al2O3: Solid-Supported Reagent Used in 1,3-Dipolar Cycloaddition Reaction of Nitrile Oxide

The stereoselective synthesis of 2-isoxazolidine through 1,3-dipolar cycloaddition reaction of nitrile oxide, which is in situ generation from aldoxime in the presence of N-bromosuccinamide and solid-supported reagent KF/Al₂O₃ at room temperature, is reported. KF/Al₂O₃ is sufficiently basic such that it can replace organic bases such as Et₃N used in typical procedures and it catalyses the reaction to enhance the rate of the reaction.