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991.
Paolo Bonomi Paola Cairoli Daniela Ubiali Carlo F. Morelli Marco Filice Ines Nieto Massimo Pregnolato Paolo Manitto Marco Terreni Giovanna Speranza 《Tetrahedron: Asymmetry》2009,20(4):467-472
(R)-2-Tetralol (R)-2a, (R)-5-hydroxy-2-tetralol (R)-2b and (R)-8-hydroxy-2-tetralol (R)-2c, which are key intermediates in the synthesis of pharmacologically active 2-aminotetralins 3, were prepared in moderate to very high enantiomeric excess (up to 99% ee) by enzymatic resolution of the corresponding racemic butyrates rac-1a, rac-1b and rac-1c, respectively, using lipases immobilized on octyl agarose. This methodology is an alternative to the microbial reduction of 2-tetralones. 相似文献
992.
993.
In solid-liquid phase transfer conditions, both the primary and the secondary alcohols react cleanly with 2,4, 6-trichloro-1,3,5-triazine to give the corresponding mono or dialkoxy derivatives depending on the reagent molar ratio. 相似文献
994.
Lili Li Jinghua Yin Giovanna Costa Paola Stagnaro 《Journal of Polymer Science.Polymer Physics》2008,46(5):506-515
A method was adopted to fix a series of polymers of PE‐b‐PEO with different PEO/PE segments on the chains of LLDPE. Maleic anhydride (MA) reacting with hydroxyl group of PE‐b‐PEO (mPE‐b‐PEO) was used as the intermediate. The structures of intermediates and graft copolymers were approved by 1H NMR and FTIR. XPS analysis revealed a great amount of oxygen on the surface of grafted copolymers although the end group of PEO was fixed on the LLDPE chains through MA. Thermal properties of the graft copolymers as determined by differential scanning calorimetry (DSC) showed that PE segments in the grafted monomers could promote the heterogeneous nucleation of the polymer, increase Tc, and crystal growth rate. While the amorphous PEO segments which attached to the crystalline PE segments in LLDPE, impaired their ability to fit the crystal lattice, and depressed the crystallization of LLDPE backbones. In this study, it was also verified through the dynamic rheological data that increasing Mn of grafted monomers significantly increased the complex viscosity and enhanced the shear‐thinning behavior. Long‐branched chains formed by grafted monomers enhanced the complex moduli (G′ and G″) value and retarded relaxation rate. However, there were little influence on the rheological properties when increasing the amounts of PEO segments (or decreasing PE segments) of grafted monomers with similar molecular weight. © 2008 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 46: 506–515, 2008 相似文献
995.
996.
Marco Bragagni Francesca Maestrelli Paola Mura 《Journal of inclusion phenomena and macrocyclic chemistry》2010,68(3-4):437-445
Interaction products of prilocaine hydrochloride (PRL), a local anesthetic agent highly soluble in water, with triacetyl-β-cyclodextrin (TAβCD), a hydrophobic CD derivative practically insoluble in water, were prepared to estimate their suitability for the development of a prolonged-release dosage form of the drug. Equimolar PRL-TAβCD solid systems were prepared by different methods (physical mixing, kneading, co-grinding, sealed-heating, coevaporation, spray-drying), in order to investigate their effectiveness and influence on the physical chemical properties of the end products. Differential scanning calorimetry, X-ray powder diffractometry, FTIR spectroscopy and environmental scanning electron microscopy (ESEM) were used for the solid-state characterization of the different PRL-TAβCD systems, whereas their in vitro dissolution properties were determined according to the dispersed amount method. On the basis of the overall solid-state studies results, the ability of the different methods to bring about effective drug-TAβCD interactions varied in the order: spray-drying > co-grinding ≈ coevaporation > sealed-heating > kneading > physical mixing. This rank order was not observed in dissolution studies, where coevaporated, kneaded and sealed-heated products exhibited very similar profiles, practically superimposable to that of pure drug and physical mixture, all reaching 100% dissolution in less than 10 min. Evidently, all these techniques gave rise only to weak surface interactions, rapidly destroyed in solution. Some decrease in dissolution rate was observed for co-ground system (100% dissolved drug after 40 min), probably due to electrostatic and aggregation phenomena associated with the high-energy mechanical treatment. A very different behaviour was shown by the spray-dried system, which give rise to an almost linear slow-dissolving profile, reaching 100% of dissolved drug after 420 min, suggesting in this case the formation of an actual inclusion compound. Thus, the drug-TAβCD product obtained by spray-drying was selected as the best candidate for the future development of a suitable prolonged-release oral dosage form of PRL. 相似文献
997.
A five-step synthesis of novel tricyclic β-lactams has been exploited by stereoselective intramolecular cycloadditions of appropriate nitrilimines 6 and 12. These labile intermediates were generated in situ from the corresponding hydrazonoyl chlorides giving rise to the hitherto unknown azeto[3′,4′:1,2]hexano[3,4-c]pyrazole and azeto[3′,4′:1,2]heptano[3,4-c]pyrazole skeletons. 相似文献
998.
Paola Morando 《Journal of Nonlinear Mathematical Physics》2013,20(1):47-59
Different kinds of reduction for ordinary differential equations, such as λ –symmetry and σ –symmetry reductions, are recovered as particular cases of Frobenius reduction theorem for distribution of vector fields. This general approach provides some hints to tackle the reconstruction problem and to solve it under suitable assumptions on the distribution involved in the reduction process. 相似文献
999.
Bounds for entries of matrix functions based on Gauss-type quadrature rules are applied to adjacency matrices associated with graphs. This technique allows to develop inexpensive and accurate upper and lower bounds for certain quantities (Estrada index, subgraph centrality, communicability) that describe properties of networks. 相似文献
1000.
In the framework of the extended irreversible thermodynamics we examine the coupling between the magnetic field and the thermal field and their influence on the evolution of a heat conducting relativistic magnetizable fluid. 相似文献