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11.
Fertout Radia Imane Ghelamallah Madani Kacimi Soufi López Paloma Navarro Corberán Vicente Cortés 《Russian Journal of Applied Chemistry》2020,93(2):289-298
Russian Journal of Applied Chemistry - Nickel catalysts supported on γ–Al2O3 doped with La2O3 and alkaline earth oxides (MgO, CaO, and SrO) were investigated in the dry reforming of... 相似文献
12.
Paloma Begines Sergio Martos Irene Lagunes Ins Maya Jos M. Padrn
scar Lpez Jos G. Fernndez-Bolaos 《Molecules (Basel, Switzerland)》2022,27(4)
Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the preparation of novel hybrids, combining both pharmacophores in order to obtain new antioxidant and antiproliferative agents. Three different families have been accessed in a straightforward and chemoselective fashion: carbohydrate-containing N-acylisoselenoureas, N-arylisoselenocarbamates and N-arylselenocarbamates. The nature of the organoselenium framework, number and position of phenolic hydroxyl groups and substituents on the aromatic scaffolds afforded valuable structure–activity relationships for the biological assays accomplished: antioxidant properties (antiradical activity, DNA-protective effects, Glutathione peroxidase (GPx) mimicry) and antiproliferative activity. Regarding the antioxidant activity, selenocarbamates 24–27 behaved as excellent mimetics of GPx in the substoichiometric elimination of H2O2 as a Reactive Oxygen Species (ROS) model. Isoselenocarbamates and particularly their selenocarbamate isomers exhibited potent antiproliferative activity against non-small lung cell lines (A549, SW1573) in the low micromolar range, with similar potency to that shown by the chemotherapeutic agent cisplatin (cis-diaminodichloroplatin, CDDP) and occasionally with more potency than etoposide (VP-16). 相似文献
13.
Eduardo Rosado Paloma Delgado-Fernndez Blanca de las Rivas Rosario Muoz Francisco Javier Moreno Nieves Corzo Cesar Mateo 《Molecules (Basel, Switzerland)》2022,27(4)
The synthesis of β-galactosyl xylitol derivatives using immobilized LacA β-galactosidase from Lactobacillus plantarum WCFS1 is presented. These compounds have the potential to replace traditional sugars by their properties as sweetener and taking the advantages of a low digestibility. The enzyme was immobilized on different supports, obtaining immobilized preparations with different activity and stability. The immobilization on agarose-IDA-Zn-CHO in the presence of galactose allowed for the conserving of 78% of the offered activity. This preparation was 3.8 times more stable than soluble. Since the enzyme has polyhistidine tags, this support allowed the immobilization, purification and stabilization in one step. The immobilized preparation was used in synthesis obtaining two main products and a total of around 68 g/L of β-galactosyl xylitol derivatives and improving the synthesis/hydrolysis ratio by around 30% compared to that of the soluble enzyme. The catalyst was recycled 10 times, preserving an activity higher than 50%. The in vitro intestinal digestibility of the main β-galactosyl xylitol derivatives was lower than that of lactose, being around 6 and 15% for the galacto-xylitol derivatives compared to 55% of lactose after 120 min of digestion. The optimal amount immobilized constitutes a very useful tool to synthetize β-galactosyl xylitol derivatives since it can be used as a catalyst with high yield and being recycled for at least 10 more cycles. 相似文献
14.
Jorge Antonio Guerrero‐Álvarez Wendy Paloma Mas‐Ku Cesar Garcías‐Morales Armando Ariza‐Castolo 《Magnetic resonance in chemistry : MRC》2010,48(5):356-361
The relative acidities of the cis and trans isomers of a series of 1,5‐oxazaspiro[5.5]undecane derivatives were determined by measuring ΔpK in acid‐base titrations followed by 1 H NMR. Relative structural stabilities were determined by measuring substituent chemical shift and γ‐gauche effects in 13C, 15N, and 17O NMR. Crystallographic characterization of a model spiro[5.5]undecane is presented to support the basicity in solid state. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
15.
Gonzalo Martínez‐García Verónica Serafín Lourdes Agüí Paloma Yáñez‐Sedeño José M. Pingarrón 《Electroanalysis》2015,27(5):1119-1126
An electrochemical immunosensor for ghrelin (GHRL) determination in saliva is reported. Anti‐GHRL was immobilized onto Protein G‐magnetic beads and a competitive immunoassay involving biotinylated GHRL and alkaline phosphatase‐streptavidin was implemented. Once conjugate was magnetically captured on a screen‐printed carbon electrode, GHRL quantization was accomplished by DPV of 1‐naphtol formed upon addition of 1‐naphtyl phosphate. A linear range between 10?3 and 103 ng/mL GHRL, and a LOD of 7 pg/mL, much smaller than those from commercial ELISA kits, were found. The usefulness of the immunosensor was demonstrated by analyzing human saliva spiked with GHRL at 0.01, 0.1, 1 and 10 ng/mL. 相似文献
16.
Moreno-Guzmán M González-Cortés A Yáñez-Sedeño P Pingarrón JM 《Analytica chimica acta》2011,692(1-2):125-130
A novel electrochemical immunosensor was developed for the determination of the hormone prolactin. The design involved the use of screen-printed carbon electrodes and streptavidin-functionalized magnetic particles. Biotinylated anti-prolactin antibodies were immobilized onto the functionalized magnetic particles and a sandwich-type immunoassay involving prolactin and anti-prolactin antibody labelled with alkaline phosphatase was employed. The resulting bio-conjugate was trapped on the surface of the screen-printed electrode with a small magnet and prolactin quantification was accomplished by differential pulse voltammetry of 1-naphtol formed in the enzyme reaction using 1-naphtyl phosphate as alkaline phosphatase substrate. All variables involved in the preparation of the immunosensor and in the electrochemical detection step were optimized. The calibration plot for prolactin exhibited a linear range between 10 and 2000 ng mL(-1) with a slope value of 7.0 nA mL ng(-1). The limit of detection was 3.74 ng mL(-1). Furthermore, the modified magnetic beads-antiprolactin conjugates showed an excellent stability. The immunosensor exhibited also a high selectivity with respect to other hormones. The analytical usefulness of the immnunosensor was demonstrated by analyzing human sera spiked with prolactin at three different concentration levels. 相似文献
17.
The present article describes the development of an analytical method for the determination of 13 perfluorinated alkyl substances (PFAS), as well as its application to real sewage sludge samples to confirm the presence of these compounds. The isolation of the analytes was performed by agitation, sonication and centrifugation techniques, followed by EnviCarb cleanup and weak anion exchange solid-phase extraction. Sensitive and selective determination was carried out by high-performance liquid chromatography?Ctandem mass spectrometry (HPLC-MS/MS). Six mass-labelled internal standards were used to ensure the accuracy of the analytical results following isotopic dilution method. Several mobile phases (acetonitrile, methanol, mixtures of both and water with ammonium acetate or acetic acid) have been tested to reach the best resolution and reproducibility results. Other parameters related to MS/MS conditions were optimized. The reliability of the method was confirmed by the evaluation of linearity (R 2?=?0.995?C0.999), accuracy (84?C99%) and injection repeatability and reproducibility (relative standard deviation below 19 and 23%, respectively). Limits of detection ranged from 0.007 to 2.217?pg. Recoveries show values higher than 80% for most of the target compounds. The application of this method to twenty real samples demonstrates its efficiency and accuracy, as well as provides for the first time to our knowledge, PFAS levels in sewage sludges from Spain. Figure
Relative composition of individual PFAS in sewage sludge. 相似文献
18.
Troncoso J Navia P Romaní L Bessieres D Lafitte T 《The Journal of chemical physics》2011,134(9):094502
The temperature and pressure dependence of isobaric thermal expansivity, α(p), in liquids is discussed in this paper. Reported literature data allow general trends in this property that are consistent with experimental evidence to be established. Thus, a negative pressure dependence is to be expected except around the critical point. On the other hand, α(p) exhibits broad regions of negative and positive temperature dependence in the (T, p) plane depending on the nature of the particular liquid. These trends are rationalized here in terms of various molecular-based equations of state. The analysis of the Lennard-Jones, hard sphere square well and restricted primitive model equations allows understanding the differences in the α(p) behavior between liquids of diverse chemical nature (polar, nonpolar, and ionic): broader regions of negative temperature and positive pressure dependencies are obtained for liquids characterized by larger ranges of the interparticle potential. Also, using the statistical associating fluid theory (SAFT) allowed the behavior of more complex systems (basically, those potentially involving chain and association effects) to be described. The effect of chain length is rather simple: increasing it is apparently equivalent to raise the interaction range. By contrast, association presents a quite complex effect on α(p), which comes from a balance between the dispersive and associative parts of the interaction potential. Thus, if SAFT parameters are adjusted to obtain low association ability, α(p) is affected by each mechanism at clearly separate regions, one at low temperature, due to association, and the other to dispersive forces, which has its origin in fluctuations related with vapor-liquid transition. 相似文献
19.
Mascaros PA Bazzicalupi C Bianchi A Giorgi C Valero MD Garzón RL Salido ML Valtancoli B 《Chemical communications (Cambridge, England)》2011,47(10):2814-2816
The synergistic action of the different binding groups of the polyfunctional HL receptor leads to the recognition of ADP over ATP in water, with a selectivity coefficient of up to 116, a phenomenon which is unprecedented in the context of synthetic receptors in water. The recognition is mostly due to the good matching between H(3)L(2+) and the protonated forms of ADP. 相似文献
20.
Pérez-Cadenas Agustín López-Garzón Rafael Godino-Salido Luz Arranz-Mascarós Paloma Gutiérrez-Valero Dolores Carillo-Márquez Tomás 《Transition Metal Chemistry》2002,27(2):184-190
Reactions of N-2-(4-amino-1,6-dihydro-1-methyl-5-nitroso-6-oxopyrimidinyl)-L-histidine with AgI and ZnII ions in 1/1 and 4/1 ligand-to-metal molar ratios, in aqueous media at 25 °C and 0.1 M KNO3 and KCl ionic strength, respectively, were followed by potentiometric techniques in order to determine formation equilibria for the complex species. The spectral curves, as a function of ligand-to-metal molar ratio at established pH values, were studied and four solid phases of stoichiometry: AgL·4H2O, Ag(HL)NO3·1.5H2O, AgL(OH)2K2·H2O and Zn(HL)2Cl2·7H2O were isolated and characterised by analytical, spectroscopic and thermal measurements. 相似文献