Observation of the enhancement in enantioselectivity with conversion for the aziridination of styrene using copper bis(oxazoline) complexes

During the aziridination of styrene using copper bis(oxazoline) complexes the ee increases with conversion due to further reactions of the product.     

The synthesis of azabicyclo[4.2.1]nonenes by the addition of a cyclopropenone to 4-vinyl substituted 1-azetines—isomers of the homotropane nucleus

The conversion of 4-vinyl substituted β-lactams into 4-vinyl substituted 1-azetines and their subsequent reaction with diphenylcyclopropenone (DPP) results in the formation of a highly functionalised 7-azabicyclo[4.2.1]nonene. This heterocyclic system is an isomer of the homotropane (9-azabicyclo[4.2.1]nonene) nucleus, which is the core structure of a class of alkaloid natural products that includes anatoxin-a. The key processes involved are two ring expansions, one of which constitutes a formal [3+2] cycloaddition and the other of which is an unusual aza-Cope (amino-Claisen) [3,3]-sigmatropic rearrangement.     

Asymmetric electrophilic amination of various carbon nucleophiles with enantiomerically pure chiral N-h oxaziridines derived from camphor and fenchone

The first two stable enantiomerically pure chiral N-H oxaziridines, derived from camphor and fenchone, are shown to act as electrophilic sources of nitrogen upon reaction with various carbon nucleophiles. Nitrogen is transferred, together with the camphor/fenchone unit, when deprotonated esters, malonates, and nitriles are used as nucleophiles. One of the ester or nitrile units in the substrate usually undergoes hydrolysis; a cyclic mechanism is proposed to account for this observation.     

Metal complexes of ligands containing intercalating units. Synthesis of nickel(II), copper(II), rhodium(II), and platinum(II) complexes with diamine-substituted acridines and quinolines,and with mitonafide [N-(2,2-dimethylaminoethyl)-3-nitro-1, 8-naphthalimide] and related ligands

Summary The preparations and characterisation are reported of a range of complexes of Ni^II, Cu^II, Rh^II, and Pt^II with 6-chloro-2-methoxyacridine substituted in the 9-position with –NH(CH₂)_nNR₂ groups (where n=2 or 3, R=H or Me), and of complexes with 7-chloroquinoline analogously substituted in the 4-position. The preparations are also reported of complexes of the types [Rh(CH₃CO₂)₂L]₂, Cu(CH₃CO₂)₂L₂, PtL₂Cl₂, and (LH)₂[PtCl₄], where L=N-(2,2-dimethylaminoethyl)-3-nitro-1, 8-naphthalimide (mitonafide) and/or its 2,2-aminoethyl-, 2,2-aminopropyl-, or 2,2-dimethylaminopropyl analogues. Initial cytotoxicity studies are reported for some of the Pt compounds.     

Microwave synthesis of polymer-embedded Pt-Ru catalyst for direct methanol fuel cell

Platinum-ruthenium nanoparticles stabilized within a conductive polymer matrix are prepared using microwave heating. Polypyrrole di(2-ethylhexyl) sulfosuccinate, or PPyDEHS, has been chosen for its known electrical conductivity, thermal stability, and solubility in polar organic solvents. A scalable and quick two-step process is proposed to fabricate alloyed nanoparticles dispersed in PPyDEHS. First a mixture of PPyDEHS and metallic precursors is heated in a microwave under reflux conditions. Then the nanoparticles are extracted by centrifugation. Physical characterization by TEM shows that crystalline and monodisperse alloyed nanoparticles with an average size of 2.8 nm are obtained. Diffraction data show that crystallite size is around 2.0 nm. Methanol electro-oxidation data allow us to propose these novel materials as potential candidates for direct methanol fuel cells (DMFC) application. The observed decrease in sulfur content in the polymer upon incorporation of PtRu nanoparticles may have adversely affected the measured catalytic activity by decreasing the conductivity of PPyDEHS. Higher concentration of polymer leads to lower catalyst activity. Design and synthesis of novel conductive polymers is needed at this point to enhance the catalytic properties of these hybrid materials.