Evaluation of an Economical Sunlamp that Emits a Near Solar UV Power Spectrum for Conducting Photoimmunological and Sunscreen Immune Protection Studies

Expense and inconvenience have restricted the use of the filtered xenon are lamp (solar simulator) as a UV source for conducting large-scale animal studies. Because sunscreen immunoprotective levels are significantly affected by the UV power spectrum of the source it is imperative that a solar simulating source be used for accurate measurements of sunscreen protection levels that are relevant to human UV exposures from sunlight. However, relatively inexpensive sunlamps, e. g. the UVA-340, that emit a UV power spectrum similar to that of a solar simulator are available. Unlike FS-type UVB sunlamps, which have a significant amount of effective immunosuppressive nonsolar UV energy at wavelengths below 295 nm, the immunosuppression effectiveness spectrum of UVA-340 sunlamps was nearly identical to that of a solar simulator. The purpose of this study was to evaluate this sunlamp for conducting photoimmunological and sunscreen immune protection studies. Groups of C3H mice were exposed to a range of UVA-340 sunlamp doses (0.25 KJ/m² to 20.0 KJ/m²) to establish a dose-response curve and determine the minimum immune suppression dose (MISD) for induction of local-type suppression of contact hypersensitivity (CH). The MISD, defined as the lowest UV dose given to produce ～50% suppression of the CH response in mice, was determined to be 1.0 kJ/m² for UVA-340 sunlamps. Immune protection tests on four marketed sunscreen lotions (sun protection factors [SPF] 4, 8, 15 and 30) were then conducted with UVA-340 sunlamps using MISD as the endpoint. The immune protection factors for these sunscreens were equivalent to the level of protection predicated by their labeled SPF. These results are similar to those we have previously obtained using a solar simulator. We conclude from these data that the immunosuppressive effects of UVA-340 sunlamps are similar to those of a solar simulator; however, further studies are needed to determine if UVA-340, or similar, sunlamps are a viable alternative to the solar simulator for conducting large-scale animal experiments that require a relevant UV solar spectrum.     

Delocalization resonance energy of the allylic radical from the geometrical isomerization of hexa-1,3,5-trienes

Thermal cis, trans geometrical isomerization theoretically involves a 90° twisted, singlet diradical-like transition state which may serve as a base for the examination of structural perturbations. Although thermal rearrangement of hexa-1, trans-3,5-triene (and all-trans octa-2,4,6-triene) to the cis isomer cannot be followed directly owing to subsequent cyclization and 1,5 hydrogen shifts, activation parameters for disappearance have been determined. Experimental complications and mechanistic uncertainties which make interpretation difficult are removed in the bicyclic hexatriene, cyclopentenylidenecyclopentene. These geometrical isomers undergo uncomplicated thermal cis, trans isomerization in vessels of lead-potash glass: log k₁ = 12·03±0·32?41·7±0·8/(0·004575T_abs). Extraction of a value for allylic delocalization energy from the behavior of hexa-1, trans-3,5-triene [log k₁ = 12·91 ± 0·47?44·3±1·2/(0·004575 T_abs)] requires corrections of the Dewar-Schmeising type for changes in hybridization of the σ bonds. Depending on whether ethylene or trans-butene is taken as standard, values of 12·2 and 13·1 kcal/mol are obtained (estimated uncertainty ± 2 kcal/mol).     

Superconductive tunneling into niobium-tin thin films

Oxide-layer tunnel junctions exhibiting both quasi-particle and Josephson tunneling were produced by overlaying lead on niobium-tin thin films. The superconducting transition temperature and average energy gap of the Nb-Sn both increased as the tin concentration was increased toward Nb₃Sn and reached maximum values of 17.2 K and 3.2 meV, respectively, or 2Δ = 4.3 kT_c.     

The diffraction of elastic waves by an imperfect fusion bond

We consider diffraction by a semi-infinite crack located alonga fusion interface between two differing elastic media. Twotypes of crack, namely open and partially closed cracks, areinvestigated. An open crack is modelled by a stress-free contactboundary condition and a partially closed crack is modelledby a spring contact boundary condition. For the latter, thejump in the stress across the crack is assumed to be proportionalto the jump in the displacement across the crack. This situationarises in, for example, a K-weld where the fine grain of theparent material (for example, ferritic or forged austeniticsteel) is in stark contrast with the coarse-grained weld metal(for example, austenitic weld metal). In the metal weld thedirection of the grain axis varies through the metal. However,diffraction is a local phenomenon and so the austenitic steelis assumed to have a zonal axis so that it may be modelled bya transversely isotropic composite. The ferritic or forged austeniticsteel will be modelled as an isotropic material.     

Possible isolation number of a matrix over nonnegative integers

Let ?₊ be the semiring of all nonnegative integers and A an m × n matrix over ?₊. The rank of A is the smallest k such that A can be factored as an m × k matrix times a k×n matrix. The isolation number of A is the maximum number of nonzero entries in A such that no two are in any row or any column, and no two are in a 2 × 2 submatrix of all nonzero entries. We have that the isolation number of A is a lower bound of the rank of A. For A with isolation number k, we investigate the possible values of the rank of A and the Boolean rank of the support of A. So we obtain that the isolation number and the Boolean rank of the support of a given matrix are the same if and only if the isolation number is 1 or 2 only. We also determine a special type of m×n matrices whose isolation number is m. That is, those matrices are permutationally equivalent to a matrix A whose support contains a submatrix of a sum of the identity matrix and a tournament matrix.     

Anomalous double peak structure in superconductor/ferromagnet tunneling density of states

We have experimentally investigated the density of states (DOS) in Nb/Ni (S/F) bilayers as a function of Ni thickness, d(F). Our thinnest samples show the usual DOS peak at +/- Delta(0), whereas intermediate-thickness samples have an anomalous "double-peak" structure. For thicker samples (d(F) > or =3.5 nm), we see an inverted DOS, which has previously only been reported in superconductor or weak-ferromagnet structures. We analyze the data using the self-consistent nonlinear Usadel equation and find that we are able to quantitatively fit the features at +/- Delta(0) -- in particular the thickness at which the inversion occurs -- only if we include a large amount of spin-orbit scattering in the model. Interestingly, we are unable to reproduce the subgap structure through the addition of any parameter(s). Therefore, the observed anomalous subgap structure represents new physics beyond that contained in the present Usadel theory.