In the proposed work, the simultaneous analysis of amlodipine–rosuvastatin and amlodipine–atorvastatin in their dosage forms was achieved. Simultaneous dissolution profiles of the amlodipine–rosuvastatin and amlodipine–atorvastatin tablets are realized using Apparatus II with a simple, accurate and precise RP-LC method. The mobile phase consisting of 0.2 % H3PO4 and pH 5:methanol:acetonitrile (46:27:27) was used. The samples of 10 µL were injected onto a Zorbax SB C18 (100 mm, 4.6 mm, 3.5 µm particle size) column with 1.2 µL min−1 flow rate. The samples were detected at 236 nm. By plotting peak area ratios vs. concentration, the linearity for amlodipine–rosuvastatin and amlodipine–atorvastatin was determined. With the developed RP-LC method, AML, ROS and ATOR were detected within the range of 0.25–10, 0.5–10 and 0.25–25 µg mL−1, respectively. LOD and LOQ values were also calculated as 0.028, 0.058, 0.021 and 0.095 µg mL−1, 0.195 µg mL−1, 0.070 µg mL−1 for AML, ROS and ATOR, respectively. System suitability tests parameters, such as capacity factor, selectivity to previous peak, selectivity to next peak, resolution to previous peak, resolution to next peak, tailing factor, theoretical number of plates, were performed and found coherent with the ICH guideline parameters. The proposed method has been extensively validated in terms of recovery, and recovery results were between 99 and 101 %. For proving the precision, between-day and within-day repeatability results of the method were proposed. The method can be used for the simultaneous determination of amlodipine–rosuvastatin and amlodipine–atorvastatin.
An analytical study is performed on steady, laminar, and fully developed forced convection heat transfer in a parallel plate
channel with asymmetric uniform heat flux boundary conditions. The channel is filled with a saturated porous medium, and the
lower and upper walls are subjected to different uniform heat fluxes. The dimensionless form of the Darcy–Brinkman momentum
equation is solved to determine the dimensionless velocity profile, while the dimensionless energy equation is solved to obtain
temperature profile for a hydrodynamically and thermally fully developed flow in the channel. Nusselt numbers for the lower
and upper walls and an overall Nusselt number are defined. Analytical expressions for determination of the Nusselt numbers
and critical heat flux ratio, at which singularities are observed for individual Nusselt numbers, are obtained. Based on the
values of critical heat flux ratio and Darcy number, a diagram is provided to determine the direction of heat transfer between
the lower or upper walls while the fluid is flowing in the channel. 相似文献
Angle-resolved X-ray photoelectron spectroscopy and contact-angle measurements guided by a signal attenuation model are utilized to extract molar composition and anion enrichment in the vacuum interface of a binary ionic liquid mixture, having a common quaternary ammonium cation and two different anions. By using the intensity ratio of the F1s peaks belonging to the two different anions recorded at the full electron take-off angle range, from 0° to 80°, we have determined that only a fractionally covered and anion enriched surface layer can predict the AR-XPS data, which is also consistent with surface tension measurements. Moreover, the more bulky and non-spherical anion enrichment is evident even at the conventional and the so assumed bulk sensitive take-off angle of 0°. This methodology provides a surface enrichment factor of the molecular ions and clearly serves as an experimental evidence for recently debated surface layering and/or island structure in ionic liquid systems. 相似文献
Titanium tetra-n-butoxide, Ti(OBun)4, and zirconium tetra-n-butoxide, Zr(OBun)4, were reacted with some well-known dioxime and monoxime ligands such as dimethylglyoxime (DMG), salicylaldoxime (SO) and
acetone oxime (AO). The structures of the resulting complexes have been determined by elemental analysis, i.r. and 1H-n.m.r. spectroscopy. The complexation ratio of both Ti(OBun)4 and Zr(OBun)4 was found to be 1:2 with DMG and SO. On the other hand, both 1:1 and 1:2 complexation ratios of the same metal alkoxides
were observed with the ligand AO. 相似文献
Modeling and control of vehicle suspension system are high noteworthy from safety to comfort. In this paper, an analytical
nonlinear half-vehicle model which is included quadratic tire stiffness, cubic suspension stiffness, and coulomb friction
is derived based on fundamental physics. A hybrid fuzzy logic approach which combines fuzzy logic and PID controllers is designed
for reducing the vibration levels of passenger seat and vehicle body. Performances of designed controllers have been evaluated
by numerical simulations. Comparisons with classical PID control, Fuzzy Logic Control (FLC) and Hybrid Fuzzy-PID control (HFPID)
have also been provided. Results of numerical simulations are evaluated in terms of time histories of displacement and acceleration
responses and ride index comparison. A good performance for the Hybrid Fuzzy-PID controller with coupled rules (HFPIDCR) is
achieved in simulation studies despite the nonlinearities. 相似文献
Two chaotic indicators namely the correlation dimension and the Lyapunov exponent methods are investigated for the daily river flow of Kizilirmak River. A delay time of 60 days used for the reconstruction is chosen after examining the first minimum of the average mutual information of the data. The sufficient embedding dimension is estimated using the false nearest neighbor algorithm, which has a value of 11. Based on these embedding parameters the correlation dimension of the resulting attractor is calculated, as well as the average divergence rate of nearby orbits given by the largest Lyapunov exponent. The presence of chaos in the examined river flow time series is evident with the low correlation dimension (2.4) and the positive value of the largest Lyapunov exponent (0.0061). 相似文献
The effect of N6-benzyladenine (BA) on the recovery of cryopreserved shoot tips of the LN33 hybrid (Vitis L.) and Troyer citrange [Poncirus trifoliata (L.) Raf. x Citrus sinensis [L.] Osbeck.] cultured in vitro was examined. For the LN33 hybrid, the presence of BA in the recovery medium was essential for survival of control and cryopreserved shoot tips, although the BA concentration did not influence the survival percentage. BA at 5, 2, and 5 microM or higher induced callus formation in control, and shoot tips cryopreserved by vitrification, and by encapsulation-dehydration, respectively. While a BA concentration of 4 microM was found optimal for recovery of control shoot tips, 1 and 2-4 microM produced the best recovery of shoot tips cryopreserved by vitrification and encapsulation-dehydration, respectively. A similar pattern of effect of BA on recovery was found for 'Troyer' citrange. Low survival of control and cryopreserved shoot tips was observed with a BA-free recovery medium. The addition of BA to the recovery medium significantly increased survival. The BA concentration that induced callus formation in shoot tips cryopreserved by encapsulation-vitrification was higher than that which induced it in those cryopreserved by encapsulation-dehydration. Recovery of control shoot tips was best with an addition of 6-10 microM BA to the medium. Optimal recovery of shoot tips cryopreserved by encapsulation-vitrification and encapsulation-dehydration was achieved with 3-4 and 2 microM BA, respectively. Results from the present study suggest that an optimal BA concentration for recovery of control shoot tips may be different from that for cryopreserved shoot tips; furthermore, the optimal BA concentration for recovery of cryopreserved shoot tips may also differ among different cryogenic procedures. 相似文献
Herein, we report on the synthesis of a microporous, three-dimensional phosphonate metal–organic framework (MOF) with the composition Cu3(H5-MTPPA)2 ⋅ 2 NMP (H8-MTPPA=methane tetra-p-phenylphosphonic acid and NMP=N-methyl-2-pyrrolidone). This MOF, termed TUB1, has a unique one-dimensional inorganic building unit composed of square planar and distorted trigonal bipyramidal copper atoms. It possesses a (calculated) BET surface area of 766.2 m2/g after removal of the solvents from the voids. The Tauc plot for TUB1 yields indirect and direct band gaps of 2.4 eV and 2.7 eV, respectively. DFT calculations reveal the existence of two spin-dependent gaps of 2.60 eV and 0.48 eV for the alpha and beta spins, respectively, with the lowest unoccupied crystal orbital for both gaps predominantly residing on the square planar copper atoms. The projected density of states suggests that the presence of the square planar copper atoms reduces the overall band gap of TUB1, as the beta-gap for the trigonal bipyramidal copper atoms is 3.72 eV. 相似文献