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21.
Onur ahin Orhan Büyükgüngr Dursun Ali Kse Hacali Necefoglu 《Acta Crystallographica. Section C, Structural Chemistry》2007,63(11):m510-m512
The title compound, [Cu(C7H5O3)2(C6H6N2O)2(H2O)2], is a two‐dimensional hydrogen‐bonded supramolecular complex. The CuII ion resides on a centre of symmetry and is in an octahedral coordination environment comprising two pyridine N atoms, two carboxylate O atoms and two O atoms from water molecules. Intermolecular N—H...O and O—H...O hydrogen bonds produce R22(4), R22(8) and R22(15) rings which lead to one‐dimensional polymeric chains. An extensive two‐dimensional network of N—H...O and O—H...O hydrogen bonds and C—H...π interactions are responsible for crystal stabilization. 相似文献
22.
Özge Dağlı Dursun Ali Köse Onur Şahin Zarife Sibel Şahin 《Journal of Thermal Analysis and Calorimetry》2017,128(3):1373-1383
The coumarilate (coum?) complexes of CoII(1), NiII(2) CuII(3) and ZnII(4) were synthesized and characterized by elemental analysis, magnetic susceptibility, solid-state UV–Vis, FTIR spectra, thermoanalytical TG–DTG/DTA and single-crystal X-ray diffraction methods. It was found that all of the complex structures have 2 mol (coum?) ligand bonded as monoanionic monodentate in the structures of 1 and 2 while they were coordinated to metal cations as monoanionic bidentate in the complexes 3 and 4. There was not any hydrate water in the metal complexes. The complexes of 1 and 2 have four moles of aqua ligand, and the other complexes have two moles. Thermal decomposition of each complex starts with dehydration, and then the decomposition of organic parts goes. The thermal dehydration of the complexes takes place in one (for the compounds of 2, 3, 4) or two (for the compound 1) steps. The decomposition mechanism and the thermal stability of the complexes under investigation were determined on the basis of their structures. Metal oxides were obtained as the final decomposition product. 相似文献
23.
A. Dilek Azaz Selma Celen Hilmi Namli Onur Turhan Raif Kurtaran Canan Kazak N. Burcu Arslan 《Transition Metal Chemistry》2007,32(7):884-888
A complex of NiII with 2,6-diacetylpyridinedihydrazone (L) towards nickel(II) has been prepared and characterized by means of elemental analyses,
IR, electronic spectra and single crystal X-ray analyses. [NiL2](NO3) was crystallized in the tetragonal space group P-4 21 c. The complex exhibits the expected coordination sphere with six
nitrogen atoms coordinated to the central NiII with a deformation from pseudo-octahedral geometry. Antimicrobial activities of the ligand and its complex were investigated. 相似文献
24.
Two most widely used approaches to treating goals of different importance in goal programming (GP) are: (1) weighted GP, where importance of goals is modelled using weights, and (2) preemptive priority GP, where a goal hierarchy is specified implying infinite trade-offs among goals placed in different levels of importance. These approaches may be too restrictive in modelling of real life decision making problems. In this paper, a novel fuzzy goal programming method is proposed, where the hierarchical levels of the goals are imprecisely defined. The imprecise importance relations among the goals are modelled using fuzzy relations. An additive achievement function is defined, which takes into consideration both achievement degrees of the goals and degrees of satisfaction of the fuzzy importance relations. Examples are given to illustrate the proposed method. 相似文献
25.
Bai R Nguyen TL Burnett JC Atasoylu O Munro MH Pettit GR Smith AB Gussio R Hamel E 《Journal of chemical information and modeling》2011,51(6):1393-1404
Compounds that modulate microtubule dynamics include highly effective anticancer drugs, leading to continuing efforts to identify new agents and improve the activity of established ones. Here, we demonstrate that [(3)H]-labeled halichondrin B (HB), a complex, sponge-derived natural product, is bound to and dissociated from tubulin rapidly at one binding site per αβ-heterodimer, with an apparent K(d) of 0.31 μM. We found no HB-induced aggregation of tubulin by high-performance liquid chromatography, even following column equilibration with HB. Binding of [(3)H]HB was competitively inhibited by a newly approved clinical agent, the truncated HB analogue eribulin (apparent K(i), 0.80 μM) and noncompetitively by dolastatin 10 and vincristine (apparent K(i)'s, 0.35 and 5.4 μM, respectively). Our earlier studies demonstrated that HB inhibits nucleotide exchange on β-tubulin, and this, together with the results presented here, indicated the HB site is located on β-tubulin. Using molecular dynamics simulations, we determined complementary conformations of HB and β-tubulin that delineated in atomic detail binding interactions of HB with only β-tubulin, with no involvement of the α-subunit in the binding interaction. Moreover, the HB model served as a template for an eribulin binding model that furthered our understanding of the properties of eribulin as a drug. Overall, these results established a mechanistic basis for the antimitotic activity of the halichondrin class of compounds. 相似文献
26.
Smith AB Risatti CA Atasoylu O Bennett CS Liu J Cheng H TenDyke K Xu Q 《Journal of the American Chemical Society》2011,133(35):14042-14053
The design, synthesis, and biological evaluation of two diminutive forms of (+)-spongistatin 1, in conjunction with the development of a potentially general design strategy to simplify highly flexible macrocyclic molecules while maintaining biological activity, have been achieved. Examination of the solution conformations of (+)-spongistatin 1 revealed a common conformational preference along the western perimeter comprising the ABEF rings. Exploiting the hypothesis that the small-molecule recognition/binding domains are likely to comprise the conformationally less mobile portions of a ligand led to the design of analogues, incorporating tethers (blue) in place of the CD and the ABCD components of the (+)-spongistatin 1 macrolide, such that the conformation of the retained (+)-spongistatin 1 skeleton would mimic the assigned solution conformations of the natural product. The observed nanomolar cytotoxicity and microtubule destabilizing activity of the ABEF analogue provide support for both the assigned solution conformation of (+)-spongistatin 1 and the validity of the design strategy. 相似文献
27.
Michael J. Patrick Chia-Yuan Chen David H. Frakes Onur Dur Kerem Pekkan 《Experiments in fluids》2011,50(4):887-904
In hemodynamics, the inherent intermittency of two-phase cellular-level flow has received little attention. Unsteadiness is
reported and quantified for the first time in the literature using a combination of fluorescent dye labeling, time-resolved
scanning confocal microscopy, and micro-particle image velocimetry (μPIV). The near-wall red blood cell (RBC) motion of physiologic
high-hematocrit blood in a rectangular microchannel was investigated under pressure-driven flow. Intermittent flow was associated
with (1) the stretching of RBCs as they passed through RBC clusters with twisting motions; (2) external flow through local
obstacles; and (3) transitionary rouleaux formations. Velocity profiles are presented for these cases. Unsteady flow clustered
in local regions. Extra-cellular fluid flow generated by individual RBCs was examined using submicron fluorescent microspheres.
The capabilities of confocal μPIV post-processing were verified using synthetic raw PIV data for validation. Cellular interactions
and oscillating velocity profiles are presented, and 3D data are made available for computational model validation. 相似文献
28.
We introduce a "double direct templating" method for obtaining hollow microspheres with periodically nanostructured walls. Silica or polystyrene colloids are dispersed in a self-assembled hexagonal lyotropic liquid crystal containing precursors for ZnS. The semiconductor ZnS mineralizes on the surface of the colloid, expressing a pore morphology that is a copy of the structure of the liquid crystal. After etching of the sacrificial colloids, hollow capsules with templated and uniform mesoporous shells are obtained. 相似文献
29.
30.
Dağlı Özge Köse Dursun Ali İçten Okan Avcı Gülçin Alp Şahin Onur 《Journal of Thermal Analysis and Calorimetry》2019,136(4):1467-1480
Journal of Thermal Analysis and Calorimetry - The coumarilate (coum?) and 1,10-phenanthroline (phen) mixed ligand complexes of Co(II) (1), Ni(II) (2) Cu(II) (3) and Zn(II) (4) were... 相似文献