Gravity driven instabilities in miscible non-Newtonian fluid displacements in porous media

Gravity driven instabilities in model porous packings of 1 mm diameter spheres are studied by comparing the broadening of the displacement front between fluids of slightly different densities in stable and unstable configurations. Water, water–glycerol and water–polymer solutions are used to vary independently viscosity and molecular diffusion and study the influence of shear-thinning properties. Both injected and displaced solutions are identical but for a different concentration of NaNO₃ salt used as an ionic tracer and to introduce the density contrast. Dispersivity in stable configuration increases with polymer concentration – as already reported for double porosity packings of porous grains. Gravity-induced instabilities are shown to develop below a same threshold Péclet number Pe for water and water–glycerol solutions of different viscosities and result in considerable increases of the dispersivity. Measured threshold Pe values decrease markedly on the contrary with polymer concentration. The quantitative analysis demonstrates that the development of the instabilities is controlled by viscosity through a characteristic gravity number G (ratio between hydrostatic and viscous pressure gradients). A single threshold value of G accounts for results obtained on Newtonian and non-Newtonian solutions.     

Corrigendum to “Characterization of Sobolev and BV spaces” [J. Funct. Anal. 261 (10) (2011) 2926–2958]

We correct a mistake in [3].     

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity

Isatin and its derivatives are important heterocycles found in nature and present in numerous bioactive compounds which possess various biological activities. Moreover, it is an essential building block in organic synthesis. The discovery of novel compounds active against human pathogenic bacteria and fungi is an urgent need, and the isatin may represent the suitable scaffold in the design of biologically relevant antimicrobials. A small library of 18 isatin hybrids was synthetized and evaluated for their antimicrobial potential on three reference strains: S. aureus, E. coli, both important human pathogens infamous for causing community- and hospital-acquired severe systemic infections; and C. albicans, responsible for devastating invasive infections, mainly in immunocompromised individuals. The study highlighted two lead compounds, 6k and 6m, endowed with inhibitory activity against S. aureus at very low concentrations (39.12 and 24.83 µg/mL, respectively).     

A decacationic ferrocene-based metallostar

Decacationic metallostars have been prepared by the reaction of permercurated ferrocene FeC₁₀(HgO₂CCF₃)₁₀ with superacidic (C₅F₅NH)(SbF₆) (pK_a = −11 estimated in H₂O) in multigram scale. In the resulting compound, [FeC₁₀Hg₁₀(NC₅F₅)_n][SbF₆]₁₀, the labile pentafluoropyridine ligands are readily displaced by acetonitrile (MeCN) or tetrahydrothiophene (THT). In the X-ray structure of [FeC₁₀Hg₁₀(THT)₁₀][SbF₆]₁₀·24 MeCN no cation–anion contacts between mercury and fluorine were observed. Moreover, cyclic voltammetry measurements of [FeC₁₀(Hg(MeCN))₁₀]¹⁰⁺ and [FeC₁₀(Hg(THT))₁₀]¹⁰⁺ revealed a (quasi)reversible one-electron oxidation of Fe(ii) to Fe(iii). From the reaction of [FeC₁₀(Hg(MeCN))₁₀]¹⁰⁺ with MoF₆ as oxidant the ferrocenium cation [FeC₁₀(Hg(MeCN))₁₀]¹¹⁺ was obtained and characterized via single crystal XRD. These electrophilic metallostars are promising potential building blocks for the synthesis of dendritic architectures containing a robust, tenfold functionalized ferrocene core.

We present the structures of unprecedented decacationic derivatives of permercurated ferrocene that can chemically be oxidized to undecacationic ferrocenium species.     

Synthesis and Biological Evaluation of New Bis-Indolinone Derivatives Endowed with Cytotoxic Activity

A series of new Knoevenagel adducts, bearing two indolinone systems, has been synthesized and evaluated on 60 human cancer cell lines according to protocols available at the National Cancer Institute (Bethesda, MD, USA). Some derivatives proved to be potent antiproliferative agents, showing GI₅₀ values in the submicromolar range. Compound 5b emerged as the most active and was further studied in Jurkat cells in order to determine the effects on cell-cycle phases and the kind of cell death induced. Finally, oxidative stress and DNA damage induced by compound 5b were also analyzed.     

Solution and Solid‐State Studies on the Halide Binding Affinity of Perfluorophenyl‐Armed Uranyl–Salophen Receptors Enhanced by Anion–π Interactions

The enhancement of the binding between halide anions and a Lewis acidic uranyl–salophen receptor has been achieved by the introduction of pendant electron‐deficient arene units into the receptor skeleton. The association and the occurrence of the elusive anion–π interaction with halide anions (as tetrabutylammonium salts) have been demonstrated in solution and in the solid state, providing unambiguous evidence on the interplay of the concerted interactions responsible for the anion binding.