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101.
Marsalek O Elles CG Pieniazek PA Pluhařová E VandeVondele J Bradforth SE Jungwirth P 《The Journal of chemical physics》2011,135(22):224510
The ultrafast dynamics of the cationic hole formed in bulk liquid water following ionization is investigated by ab initio molecular dynamics simulations and an experimentally accessible signature is suggested that might be tracked by femtosecond pump-probe spectroscopy. This is one of the fastest fundamental processes occurring in radiation-induced chemistry in aqueous systems and biological tissue. However, unlike the excess electron formed in the same process, the nature and time evolution of the cationic hole has been hitherto little studied. Simulations show that an initially partially delocalized cationic hole localizes within ~30 fs after which proton transfer to a neighboring water molecule proceeds practically immediately, leading to the formation of the OH radical and the hydronium cation in a reaction which can be formally written as H(2)O(+) + H(2)O → OH + H(3)O(+). The exact amount of initial spin delocalization is, however, somewhat method dependent, being realistically described by approximate density functional theory methods corrected for the self-interaction error. Localization, and then the evolving separation of spin and charge, changes the electronic structure of the radical center. This is manifested in the spectrum of electronic excitations which is calculated for the ensemble of ab initio molecular dynamics trajectories using a quantum mechanics/molecular mechanics (QM∕MM) formalism applying the equation of motion coupled-clusters method to the radical core. A clear spectroscopic signature is predicted by the theoretical model: as the hole transforms into a hydroxyl radical, a transient electronic absorption in the visible shifts to the blue, growing toward the near ultraviolet. Experimental evidence for this primary radiation-induced process is sought using femtosecond photoionization of liquid water excited with two photons at 11 eV. Transient absorption measurements carried out with ~40 fs time resolution and broadband spectral probing across the near-UV and visible are presented and direct comparisons with the theoretical simulations are made. Within the sensitivity and time resolution of the current measurement, a matching spectral signature is not detected. This result is used to place an upper limit on the absorption strength and/or lifetime of the localized H(2)O(+) ((aq)) species. 相似文献
102.
A new version of the multireference Mukherjee's coupled cluster method with perturbative triexcitations has been formulated, which is based on the uncoupled approximation applied to the triples equation. In contrast to the method developed by Evangelista et al. [J. Chem. Phys. 132, 074107 (2010)], the proposed approach does not require to solve the equation for T(3) amplitudes iteratively, yet yields results of essentially the same quality. The method, abbreviated as MR MkCCSD(Tu), has been implemented in the ACES II program package and its assessment has been performed on the BeH(2) model and on the tetramethyleneethane molecule. 相似文献
103.
Ondrej Hutník 《Integral Equations and Operator Theory》2011,71(3):357-388
We study a parameterized family of Toeplitz-type operators with respect to specific wavelets whose Fourier transforms are
related to Laguerre polynomials. On the one hand, this choice of wavelets underlines the fact that these operators acting
on wavelet subspaces share many properties with the classical Toeplitz operators acting on the Bergman spaces. On the other
hand, it enables to study poly-Bergman spaces and Toeplitz operators acting on them from a different perspective. Restricting
to symbols depending only on vertical variable in the upper half-plane of the complex plane these operators are unitarily
equivalent to a multiplication operator with a certain function. Since this function is responsible for many interesting features
of these Toeplitz-type operators and their algebras, we investigate its behavior in more detail. As a by-product we obtain
an interesting observation about the asymptotic behavior of true poly-analytic Bergman spaces. Isomorphisms between the Calderón-Toeplitz
operator algebras and functional algebras are described and their consequences in time-frequency analysis and applications
are discussed. 相似文献
104.
Ondrej Zitka Helena Skutkova Vojtech Adam Libuse Trnkova Petr Babula Jaromir Hubalek Ivo Provaznik Rene Kizek 《Electroanalysis》2011,23(7):1556-1567
We studied the electrochemical behaviour of adenine derivates (adenosine, 2‐aminopurine, 2,6‐diaminopurine, 6‐benzyl‐aminopurine, adenosine monophosphate, cyclic adenosine monophosphate, nicotinamide adenine dinucleotide, adenosine triphosphate, S‐adenosyl‐L ‐methionine, and synthetic derivatives AD‐3, AD‐6 and AD‐9) using flow injection analysis with electrochemical detection using a glassy carbon electrode. The influences of pH, flow rate and potential on the signal height of the studied derivates were tested. The optimal pH was 3, the flow rate of the mobile phase 0.75 mL min?1 and the potential 1100 mV. Further, we attempted to characterize each of the studied derivatives by mathematical equations and classic analytical parameters. The lowest detection limit was estimated for adenine as 0.9 nM and 2‐aminopurine as 0.5 nM. 相似文献
105.
Recently, several different classes of endogenous lipids have been reported that display antidiabetic and anti-inflammatory effects. Due to their minute presence in human samples, access to synthetic material of each enantiomer becomes necessary for exact structural elucidation and extensive biological evaluation. Herein we report the multi-milligram synthesis of both enantiomers of the docosahexaenoic acid ester of 13-hydroxyoctadecadienoic acid (13-DHAHLA) from commercially available starting materials. 相似文献
106.
Dr. Raoul De Gasparo Ondrej Halgas Dora Harangozo Dr. Marcel Kaiser Prof. Dr. Emil F. Pai Prof. Dr. R. Luise Krauth-Siegel Prof. Dr. François Diederich 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(49):11416-11421
Trypanothione reductase (TR) plays a key role in the unique redox metabolism of trypanosomatids, the causative agents of human African trypanosomiasis (HAT), Chagas’ disease, and leishmaniases. Introduction of a new, lean propargylic vector to a known class of TR inhibitors resulted in the strongest reported competitive inhibitor of Trypanosoma (T.) brucei TR, with an inhibition constant Ki of 73 nm , which is fully selective against human glutathione reductase (hGR). The best ligands exhibited in vitro IC50 values (half-maximal inhibitory concentration) against the HAT pathogen, T. brucei rhodesiense, in the mid-nanomolar range, reaching down to 50 nm. X-Ray co-crystal structures confirmed the binding mode of the ligands and revealed the presence of a HEPES buffer molecule in the large active site. Extension of the propargylic vector, guided by structure-based design, to replace the HEPES buffer molecule should give inhibitors with low nanomolar Ki and IC50 values for in vivo studies. 相似文献
107.
Optimization Letters - In the profitable tour problem, the carrier decides whether to visit a particular customer with respect to the prize the customer offers for being visited and traveling cost... 相似文献
108.
Maťko Igor Šauša Ondrej Čechová Katarína Jesenák Karol 《Journal of Thermal Analysis and Calorimetry》2018,133(1):247-254
Journal of Thermal Analysis and Calorimetry - The aim of this study is to characterize adsorbed liquid in montmorillonite structure for different levels of adsorption by both thermoanalytical and... 相似文献
109.
Zbynek Heger Ondrej Zitka Zdenka Fohlerova Miguel Angel Merlos Rodrigo Jaromir Hubalek Rene Kizek Vojtech Adam 《Chemical Papers》2015,69(1):54-61
Due to the considerable stability of green fluorescent proteins and their capacity to be readily permutated or mutated, they may be exploited in multiple ways to enhance the functionality of in vitro biosensors. Many possibilities, such as the formation of chimeras with other proteins or antibodies, as well as Förster resonance emission transfer performance, may be used for the highly sensitive and specific detection of the target molecules. This review considers the great potential of green fluorescent proteins as the fluorescent probing or recognition biomolecule in various in vitro biosensors applications, as well as obstacles associated with their use. 相似文献
110.
Martina?PospisilovaEmail author Vojtech?Zapotocky Kristina?Nesporova Milan?Laznicek Alice?Laznickova Ondrej?Zidek Martin?Cepa Hana?Vagnerova Vladimir?Velebny 《Journal of nanoparticle research》2017,19(2):80
We report on the 59Fe radiolabelling of iron oxide nanoparticle cores through post-synthetic isotope exchange (59Fe-IONPex) and precursor labelling (59Fe-IONPpre). Scanning electron microscopy and dynamic light scattering measurements showed no impact of radiolabelling on nanoparticle size or morphology. While incorporation efficiencies of these methods are comparable—83 and 90% for precursor labelling and post-synthetic isotope exchange, respectively—59Fe-IONPpre exhibited much higher radiochemical stability in citrated human plasma. Quantitative ex vivo biodistribution study of 59Fe-IONPpre coated with triethylene glycol was performed in Wistar rats. Following the intravenous administration, high 59Fe concentration was observed in the lung and the organs of the reticuloendothelial system such as the liver, the spleen and the femur. 相似文献