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631.
J.V. MichalowiczJ.M. Nichols F. BucholtzC.C. Olson 《Statistics & probability letters》2011,81(8):1233-1240
This work generalizes a widely used result derived by L. Isserlis for the expectations of products of jointly Gaussian random variables by extending it to include mixed-Gaussian random variables. 相似文献
632.
Rhodium-catalyzed oxidative cyclization of allylic hydroxylamine-derived sulfamate esters furnishes a novel family of bicyclic aziridines that serve as functional precursors to substituted diamines. Investigations with the N4-Troc form of these heterocycles have led to manifold improvements in reaction performance and scope and have revealed unique differences in the stability and reactivity of such compounds dictated by the choice of N4-protecting group. 相似文献
633.
We provide an assessment of a computational strategy for protein structure refinement that combines self‐guided Langevin dynamics with umbrella‐potential biasing replica exchange using the radius of gyration as a coordinate (Rg‐ReX). Eight structurally nonredundant proteins and their decoys were examined by sampling conformational space at room temperature using the CHARMM22/GBMV2 force field to generate the ensemble of structures. Two atomic statistical potentials (RWplus and DFIRE) were analyzed for structure identification and compared to the simulation force‐field potential. The results show that, while the Rg‐ReX simulations were able to sample conformational basins that were more structurally similar to the X‐ray crystallographic structures than the starting first‐order ranked decoys, the potentials failed to detect these basins from refinement. Of the three potential functions, RWplus yielded the highest accuracy for recognition of structures that refined to an average of nearly 20% increase in native contacts relative to the starting decoys. The overall performance of Rg‐ReX is compared to an earlier study of applying temperature‐based replica exchange to refine the same decoy sets and highlights the general challenge of achieving consistently the sampling and detection threshold of 70% fraction of native contacts. © 2013 Wiley Periodicals, Inc. 相似文献
634.
Christopher A. Crutchfield Matthew T. Olson Evgenia Gourgari Maria Nesterova Constantine A. Stratakis Alfred L. Yergey 《Journal of the American Society for Mass Spectrometry》2013,24(2):230-237
We have developed new applications of the pseudocolor plot for the analysis of LC/MS data. These applications include spectral averaging, analysis of variance, differential comparison of spectra, and qualitative filtering by compound class. These applications have been motivated by the need to better understand LC/MS data generated from analysis of human biofluids. The examples presented use data generated to profile steroid hormones in urine extracts from a Cushing’s disease patient relative to a healthy control, but are general to any discovery-based scanning mass spectrometry technique. In addition to new visualization techniques, we introduce a new metric of variance: the relative maximum difference from the mean. We also introduce the concept of substructure-dependent analysis of steroid hormones using precursor ion scans. These new analytical techniques provide an alternative approach to traditional untargeted metabolomics workflow. We present an approach to discovery using MS that essentially eliminates alignment or preprocessing of spectra. Moreover, we demonstrate the concept that untargeted metabolomics can be achieved using low mass resolution instrumentation. 相似文献
635.
Barin G Coskun A Friedman DC Olson MA Colvin MT Carmielli R Dey SK Bozdemir OA Wasielewski MR Stoddart JF 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(1):213-222
Rotacatenanes are exotic molecular compounds that can be visualized as a unique combination of a [2]catenane and a [2]rotaxane, thereby combining both the circumrotation of the ring component (rotary motion) and the shuttling of the dumbbell component (translational motion) in one structure. Herein, we describe a strategy for the synthesis of a new switchable [3]rotacatenane and the investigation of its switching properties, which rely on the formation of tetrathiafulvalene (TTF) radical π-dimer interactions-namely, the mixed-valence state (TTF(2) )(+.) and the radical-cation dimer state (TTF(+.) )(2) -under ambient conditions. A template-directed approach, based on donor-acceptor interactions, has been developed, resulting in an improved yield of the key precursor [2]catenane, prior to rotacatenation. The nature of the binding between the [2]catenane and selected π-electron-rich templates has been elucidated by using X-ray crystallography and UV/Vis spectroscopy as well as isothermal titration microcalorimetry. The multistate switching mechanism of the [3]rotacatenane has been demonstrated by cyclic voltammetry and EPR spectroscopy. Most notably, the radical-cation dimer state (TTF(+.) )(2) has been shown to enter into an equilibrium by forming the co-conformation in which the two 1,5-dioxynaphthalene (DNP) units co-occupy the cavity of tetracationic cyclophane, thus enforcing the separation of TTF radical-cation dimer (TTF(+.) )(2) . The population ratio of this equilibrium state was found to be 1:1. We believe that this research demonstrates the power of constructing complex molecular machines using template-directed protocols, enabling us to make the transition from simple molecular switches to their multistate variants for enhancing information storage in molecular electronic devices. 相似文献
636.
As a result of the cochlea's nonlinear mechanics, stimulation by two tones results in the generation of distortion products (DPs) at frequencies flanking the primary tones. DPs are measurable in the ear canal as oto-acoustic emissions, and are used to noninvasively explore cochlear mechanics and diagnose hearing loss. Theories of DP emissions generally include both forward and reverse cochlear traveling waves. However, a recent experiment failed to detect the reverse-traveling wave and concluded that the dominant emission path was directly through the fluid as a compression pressure [Ren, 2004, Nat. Neurosc.7, 333-334]. To explore this further, we measured intracochlear DPs simultaneously with emissions over a wide frequency range, both close to and remote from the basilar membrane. Our results support the existence of the reverse-traveling wave: (1) They show spatial variation in DPs that is at odds with a compression pressure. (2) Although they confirm a forward-traveling character of intraocochlear DPs in a broad frequency region of the best frequency, this behavior does not refute the existence of reverse-traveling waves. (3) Finally, the results show that, in cases in which it can be expected, the DP emission is delayed relative to the DP in a way that supports reverse-traveling-wave theory. 相似文献
637.
Main observation and conclusion
A catalytic two-component three-centered(2C3C)Ugi-type reaction was developed for the synthesis of L-1-deoxynojirimycin(DNJ)isom... 相似文献
638.
Zhimin Sun Yanhai Ni Thirumurugan Prakasam Dr. Wenqi Liu Dr. Huang Wu Zhao Zhang Haiting Di Prof. Kim K. Baldridge Prof. Ali Trabolsi Prof. Mark A. Olson 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(36):9360-9371
Stimuli-responsive chromic materials such as photochromics, hydrochromics, thermochromics, and electrochromics have a long history of capturing the attention of scientists due to their potential industrial applications and novelty in popular culture. However, hybrid chromic materials that combine two or more stimuli-triggered color changing properties are not so well known. Herein, we report a design strategy that has led to a series of emissive 1,8-naphthalimide-viologen dyads which exhibit unusual dual photochromic and hydrochromic switching behavior in the solid-state when embedded in a cellulose matrix. This behavior manifests as reversible solid state fluorescence hydrochromism upon changes in atmospheric relative humidity (RH), and reversible solid state photochromism upon generation of a cellulose-stabilized viologen radical cation. In this design strategy, the bipyridinium unit serves as both a water-sensitive receptor for the hydrochromic fluorophore-receptor system, and a photochromic group, capable of eliciting its own visible colorimetric response, generating a fluorescence quenching radical cation with prolonged exposure to ultraviolet (UV) light. These dyes can be inkjet-printed onto cellulose paper or drop-cast as cellulose powder-based films and can be unidirectionally cycled between three different states which can be characteristically visualized under UV light or visible light. The material's photochromism, hydrochromism, and underlying mechanism of action was investigated using computational analysis, dynamic vapor sorption/desorption isotherms, electron paramagnetic resonance spectroscopy, and variable humidity UV-Vis adsorption and fluorescence spectroscopies. 相似文献
639.
G. A. Olson 《Fresenius' Journal of Analytical Chemistry》1911,50(4-5):315
Ohne Zusammenfassung 相似文献
640.