Opening of Glycidol with Phenols in Water Using Catalytic Amounts of Sodium Hydroxide: A Practical Synthesis of 3-Aryloxy-1,2-propanediols

A practical synthesis of enantiopure 3-aryloxy-1,2-propanediols by opening of (S)-glycidol with phenols under aqueous conditions using catalytic amounts of sodium hydroxide is described.     

Highly selective methanesulfonic acid-catalyzed 1,3-isomerization of allylic alcohols

Secondary and tertiary allylic alcohols undergo 1,3-isomerization smoothly in the presence of methanesulfonic acid under simple and efficient conditions to afford selectively the corresponding primary E-allylic alcohols in excellent yields.     

Asymmetric synthesis of (3R-trans)-and (3S-cis)-hydroxy-5-pentanolides

The synthesis of optically active lactones 11a and 11b is reported, utilizing chiral aldehyde 7 as the key intermediate.     

A novel two-carbon homologation with N-vinylacetamides and ethyl vinyl ether as acetaldehyde anion equivalents in the synthesis of 9H-xanthene, 9H-thioxanthene, and 9,10-dihydro-9-acridine carboxaldehydes

An efficient synthesis of 9H-xanthene-9-carboxaldehyde (3a), 9H-thioxanthene-9-carboxaldehyde (3b), and 9,10-dihydro-10-methyl-9-acridinecarboxaldehyde (3c) by a novel two-carbon homologation of xanthydrol (1a), thioxanthydrol (1b), and 9,10-dihydro-10-methyl-9-acridinol (1c), respectively, using N-vinylacetamides (2a,b) or ethyl vinyl ether (2c) as acetaldehyde anion equivalents, is described.     

Regioselective ozonolytic cleavage of unsymmetric cycloalkenes

Aldehyde 2 was prepared in a one-pot sequence from olefin 12; olefin 6 did not react similarly. Possible reasons for the differences are discussed.     

An efficient and practical N-methylation of amino acid derivatives

[reaction: see text] An efficient and practical N-methylation of amino acid derivatives with dimethyl sulfate in the presence of sodium hydride and a catalytic amount of water is described. Reaction of water with sodium hydride generated highly reactive dry sodium hydroxide, which led to much faster reaction rates than powdered sodium hydroxide itself.     

Improved Synthesis of Fluoroalkyl and Fluoroaryl Substituted 2-Aminopyrimidines

Fluoroalkyl and fluoroaryl substituted 2-aminopyrimidines have been prepared in good yields by the cyclization of guanidine salts with fluorine substituted β-diketones in sodium isopropoxide/isopropanol at reflux.     

A New Reaction of Aminoiminomethanesulfonic Acid with Methyl Anthranilates

A new double guanidinylation and cyclization reaction of aminoiminomethanesulfonic acid with methyl anthranilates to yield 5H-quinazolino[3,2-a]quinazoline-5,12 (6H)-diones is described.     

Deprotection of N-tosylated indoles and related structures using cesium carbonate

A very mild, efficient, and convenient method for deprotection of N-tosylated indoles and related structures by cesium carbonate in THF-MeOH is described.