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81.
Two new isoflavanone and one new 3-arylcoumarin derivatives, along with a known compound 3,4-didehydroglabridin, were isolated from commercially available licorice of Glycyrrhiza glabra origin, and their structures were elucidated on the basis of both the chemical and spectroscopic evidence. 相似文献
82.
We present a first successful theoretical account of the ion mobilities of and in helium gas at 4.3 K. Measured mobilities of various molecular ions at low effective temperatures reportedly tend to values smaller than their polarization limits, with the exception of N(2)(+). The present theoretical results obtained by the classical trajectory calculations agree with the experimental ones very well, and make it definitive that the anomalous decline of molecular ion mobility is caused by a Feshbach-like resonance due to the anisotropic interaction potential between a molecular ion and a helium atom. The mechanism thus revealed is supported by quantitative quantum mechanical calculations. The process appears very similar to that of laser cooling. 相似文献
83.
84.
Endosomal escape in cell-penetrating peptide (CPP)-based drug/macromolecule delivery systems is frequently insufficient. The CPP-fused molecules tend to remain trapped inside endosomes and end up being degraded rather than delivered into the cytosol. One of the methods for endosomal escape of CPP-fused molecules is photochemical internalization (PCI), which is based on the use of light and a photosensitizer and relies on photoinduced endosomal membrane destabilization to release the cargo molecule. Currently, it remains unclear how this delivery strategy behaves after photostimulation. Recent findings, including our studies using CPP-cargo-photosensitizer conjugates, have shed light on the photoinduced endosomal escape mechanism. In this review, we discuss the structural design of CPP-photosensitizer and CPP-cargo-photosensitizer conjugates, and the PCI mechanism underlying their application. 相似文献
85.
86.
Minakawa T Toume K Ahmed F Sadhu SK Ohtsuki T Arai MA Ishibashi M 《Chemical & pharmaceutical bulletin》2010,58(11):1549-1551
In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)-furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines. 相似文献
87.
M. Yamamoto J. Ohea T. Ohtsuki J. Nitta B. Kramer 《Physica E: Low-dimensional Systems and Nanostructures》2005,29(3-4):490
We investigate numerically the spin polarization of the current in the presence of Rashba spin–orbit interaction (RSOI) in a 3-terminal conductor. We use equation-of-motion method to simulate the time evolution of the wave packet and focus on single-channel transport. A T-shaped conductor with uniform RSOI proposed by Kiselev and Kim and a Y-shaped conductor with nonuniform RSOI are considered. In the T-shaped conductor, the strength of RSOI is assumed to be uniform. We have found that the spin polarization becomes nearly 100% with little loss of conductance for sufficiently strong spin–orbit coupling. This is due to the spin-dependent group velocity of electrons at the junction which causes the spin separation. In the Y-shaped conductor, the strength of RSOI is modulated perpendicular to the charge current. A spatial gradient of effective magnetic field due to the nonuniform RSOI causes the Stern–Gerlach type spin separation. The direction of the polarization is perpendicular to the current and parallel to the spatial gradient. Again almost 100% spin polarization can be realized by this spin separation. 相似文献
88.
Hamamoto T Sisido M Ohtsuki T Taki M 《Chemical communications (Cambridge, England)》2011,47(32):9116-9118
By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein. 相似文献
89.
In this study, we analyze the surface roughness of human skin using human visual assessment and statistical features of three-dimensional shape data and goniometric reflectance data. We use eight skin replicas taken from the cheeks of women. First, we perform human visual assessment to obtain the roughness rankings. Second, we measure three roughness parameters by currently used methods. These parameters show no significant correlation with the roughness rankings. Third, we measure the skin surface shape to calculate surface normal vectors. We show that the surface normal distribution of the skin is isotropic and Gaussian, and the standard deviation has a good correlation with the roughness rankings. Finally, we analyze the goniometric reflectance data to approximate the surface reflection using the Oren-Nayar model. We find that the standard deviation estimated using this model corresponds to the roughness rankings. Thus, this parameter can be effectively used for describing skin roughness. 相似文献
90.
Tet Htut Soe Tomotaka Nanjo Kazunori Watanabe Takashi Ohtsuki 《Photochemistry and photobiology》2019,95(6):1395-1402
The inefficient endosomal escape of drugs or macromolecules is a major obstacle to achieving successful delivery to therapeutic targets. An efficient approach to circumvent this barrier is photochemical internalization (PCI), which uses light and photosensitizers for endosomal escape of the delivered macromolecules. The PCI mechanism is related to photogenerated singlet oxygen, but the mechanism is still unclear. In this study, we examined the relation of PCI to heat, pH and Ca2+ ions using cell penetrating peptide (CPP)‐cargo‐photosensitizer (Alexa546 or Alexa633) conjugates. A cell temperature changing experiment demonstrated that heat (thermal mechanism) does not significantly contribute to the photoinduced endosomal escape. Inhibition of V‐ATPase proton pump activity and endosomal pH upregulation indicated that PCI‐mediated endosomal escape needs endosomal acidification prior to photoirradiation. Imaging of the CPP‐cargo‐photosensitizer and Ca2+ ions during photostimulation showed that intracellular calcium increase is not the cause of the endosomal escape of the complex. The increment is mainly due to Ca2+ influx. These findings show the importance of extra‐ and intracellular milieu conditions in the PCI mechanism and enrich our understanding of PCI‐related changes in cell. 相似文献