The bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor): a milestone protein

The pancreatic Kunitz inhibitor, also known as aprotinin, bovine basic pancreatic trypsin inhibitor (BPTI), and trypsin-kallikrein inhibitor, is one of the most extensively studied globular proteins. It has proved to be a particularly attractive and powerful tool for studying protein conformation as well as molecular bases of protein/protein interaction(s) and (macro)molecular recognition. BPTI has a relatively broad specificity, inhibiting trypsin- as well as chymotrypsin- and elastase-like serine (pro)enzymes endowed with very different primary specificity. BPTI reacts rapidly with serine proteases to form stable complexes, but the enzyme: inhibitor complex formation may involve several intermediates corresponding to discrete reaction steps. Moreover, BPTI inhibits the nitric oxide synthase type-I and -II action and impairs K+ transport by Ca2+-activated K+ channels. Clinically, the use of BPTI in selected surgical interventions, such as cardiopulmonary surgery and orthotopic liver transplantation, is advised, as it significantly reduces hemorrhagic complications and thus blood-transfusion requirements. Here, the structural, inhibition, and bio-medical aspects of BPTI are reported.     

Les axiomes de la mecauique du point materiel

Résumé L'examen préalable des concepts mathématiques indispensables aux énoncés des Axiomes de la Mécanique fait partie integrante de ces énoncés. Le concepts qui interviennent ce sont d'abord ceux concernant certains espaces ponctuels ou vectoriels euclidiens et les produits cartésiens qui en sont constitués, en suite ceux rélatifs aux formes linéaires ou bilinéaires attachées à ces espaces. Après avoir définit la série d'espaces et de formes qui sont nécessaires pour constituer la Mécanique inertiale du point, nous devons passer à la Mécanique du point dans un champ. Pour y parvenir nous devons dotér d'abord l'espace R de la metrique qui s'impose et en constituer ainsi l'univers deEinstein-Minkowski. Avec R comme base, nous formons un espace fibré qui est le siège du champ de vecteurs deMaxwell et ensuite un second espace, fibré par un espace de tenseurs, qui nous donne les champs non holonomes des mésons et d'autres champs dont l'interprétation reste encore à être donnée. A M. Enrico Bompiani pour son Jubilé scientifique.     

Approximation and Markov moment problem on concrete spaces

Polynomial approximation results on unbounded subsets of \(R^n\) are discussed. By applying these results, one obtains characterizations of the existence of the solutions of the multidimensional vector valued moment problems in terms of quadratic mappings. Two other applications related to the Markov moment problem are considered. The main ingredients of the proofs are the extension of linear operator’s results, with two constraints. All sections contain statements using Hahn–Banach principle or its generalizations, as well as natural order relations on function or operator spaces. One solves the difficulty created by the existence of positive polynomials that are not sums of squares in several dimensions.     

Über die Invarianten von Linienelementen und die projektive Geometrie der Kurvengewebe

Ohne ZusammenfassungNach einem am 8. Jänner 1941 in Hamburg gehaltenen Vortrag. Mit 3 Figuren im Text     

Sulla geometria proiettiva differenziale di una superficie auolonoma nello spazio ordinario

Sunto. Osservazioni, ragguagli, notizie su precedenti lavori concernenti le superficie anolonome e le quadriche diMoutard per esse; ulteriori sviluppi concernenti gli intorni del3 ^o e del4 ^o ordine di un punto su di una superficie anolonoma.