Synthese stereoisomerer Pinanthromboxane und Evaluation der Verbindungen als Plättchenaggregationsinhibitoren

Synthesis of Stereisomeric Pinanthromboxane Derivatives and Evaluation of the Compounds as Platelet Aggregation Inhibitors Starting from the two enantiomeric myrtenols ((?)- 1 and (+)- 1 ; cf. Scheme 1), the synthesis of twelve stereoisomeric pinanthromboxane derivatives ((+)- and (?)- 10, -11, -14, -15, -21 and -22 ) is described (cf. Schemes 1–4). Biological data from the evaluation as platelet aggregation inhibitors (cf. Table 6 and 7), thromboxane synthetase inhibitors (cf. Table 8) and from the assessment as antagonists of leukotriene E₄ induced bronchoconstriction (cf. Table 9) are presented.     

Parameters for multiple constraints

A simple procedure is outlined, to obtain good initial guesses for the parameters for multiple constraints.     

Problem Department

This department aims to provide problems of varying degrees of difficulty which will interest anyone engaged in the study of mathematics. All readers are invited to propose problems and to solve problems here proposed. Drawings to illustrate the problems should be well done in India ink. Problems and solutions will be credited to their authors. Each solution or proposed problem sent the Editor should have the author's name introducing the problem or solution as on the following pages. The Editor of the Department desires to serve her readers by making it interesting and helpful to them. Address suggestions and problems to Margaret F. Willerding, Mathematics Dept., San Diego State University; San Diego Calif., 92115.