On Suboptimal LCS-alignments for Independent Bernoulli Sequences with Asymmetric Distributions

Let X = X ₁ ... X _n and Y = Y ₁ ... Y _n be two binary sequences with length n. A common subsequence of X and Y is any subsequence of X that at the same time is a subsequence of Y; The common subsequence with maximal length is called the longest common subsequence (LCS) of X and Y. LCS is a common tool for measuring the closeness of X and Y. In this note, we consider the case when X and Y are both i.i.d. Bernoulli sequences with the parameters ϵ and 1 − ϵ, respectively. Hence, typically the sequences consist of large and short blocks of different colors. This gives an idea to the so-called block-by-block alignment, where the short blocks in one sequence are matched to the long blocks of the same color in another sequence. Such and alignment is not necessarily a LCS, but it is computationally easy to obtain and, therefore, of practical interest. We investigate the asymptotical properties of several block-by-block type of alignments. The paper ends with the simulation study, where the of block-by-block type of alignments are compared with the LCS.     

N-tert-Butoxycarbonyl (BOC) Deprotection Using Boron Trifluoride Etherate

A mild and efficient procedure is described for the removal of the tert-butoxycarbonyl (BOC) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.     

Novel Synthesis of (+/−)-cis-4-Amino-2-cyclopentene-1-methanol,a Key Intermediate in the Preparation of Carbocyclic 2′,3′-Didehydro-2′,3′-dideoxy Nucleosides

Abstract

Novel synthetic routes directed toward the preparation of (+/?)-cis -4-amino-2-cyclopentene-1-methanol are described. The routes investigated involve azide openings of chiral and non-chiral cyclopentyl epoxides.     

On the structure of the Bochner–Martinelli residue currents

The paper presents a survey of the main results of I.M. Vinogradov.     

Crystal habit modifications of imatinib mesylate under various precipitation conditions

Abstract  

Crystals of the α-form of imatinib mesylate with various habits (e.g., polyhedral-like and plate-like) were prepared from various organic solvents (e.g., butyl lactate, 4-methyl-2-pentanone, 2-methyl-2-butanol, 2-isopropoxyethanol, propyl ether) by several precipitation methods. The methods provide imatinib mesylate in a non-needle-shaped crystalline α-form. The crystal modification was identified by hot-stage microscopy, scanning electron microscopy, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRPD). The analyses by DSC, IR, and XRPD indicate that imatinib mesylate crystals with various habits have the same crystal structure. The plate-like habit has been also observed in the system where the organic solvent acts as a precipitant.     

Cytotoxic and NF-κB inhibitory sesquiterpene lactones from Piptocoma rufescens

Six new (1-6) and eight known germacranolide-type sesquiterpene lactones, along with several known phenylpropanol coumarates and methylated flavonoids, were isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. The new compounds were identified by analysis of their spectroscopic data, with the molecular structure of 3 being established by single-crystal X-ray diffraction. The absolute configurations of the sesquiterpene lactones isolated were determined from their CD and NOESY NMR spectra, together with the analysis of Mosher ester reactions. Bioassay screening results showed the majority of the sesquiterpene lactones isolated (1-13) to be highly cytotoxic toward the HT-29 human colon cancer cell line, with the most potent compound being 15-deoxygoyazensolide (10, IC(50), 0.26 μM). In addition, several of the sesquiterpene lactones exhibited NF-κB (p65) inhibitory activity.