Iron(III) metallomesogen of [N2O2] donor Schiff base ligand containing 4-substituted alkoxy chains

Two new square pyramidal iron(III)-complexes of ‘salen’-type Schiff base ligands containing 4-substituted long alkoxy arms on the aromatic rings, [Fe(4-C₁₆H₃₃O)₂salcn)]Cl and [Fe(4-C₁₆H₃₃O)₂salophen)]Cl {salcn = N,N?-cyclohexanebis(salicylideneiminato) and salophen = N,N?-phenylenebis(salicylideneiminato)}, have been successfully synthesised, and their mesomorphic property investigated. The ligands and complexes were characterised by elemental analyses, UV–Vis, FT-IR, ESI–MS, ¹H and ¹³C NMR (for ligands only). The phase behaviour of the iron(III) complexes were ascertained by differential scanning calorimetry, polarising optical microscopy and variable temperature PXRD study. Ligands are non-mesomorphic, however, mesomorphism got induced upon complexation with the iron(III) centre. X-ray diffraction study revealed a layer-like arrangement of the five coordinated mesomorphic iron(III) complexes. The mesophase is stable over a wide range of temperature. The density functional theory calculations were carried out using Gaussian 09 program at B3LYP level using unrestricted 6–31G (d, p) basis set to obtain the optimised geometry of the iron(III) complexes.     

Investigation on threshold power of stimulated Brillouin scattering in photonic crystal fiber

We have developed a theoretical approach to simulate stimulated Brillouin scattering (SBS) generation in photonic crystal fiber (PCF). The threshold condition for the SBS occurrence has been derived as a function of fiber parameters and input pump power. A particular emphasis is given to the influence of the input pump power and fiber length on the Brillouin gain in the PCF. To assess threshold pump power accurately, the pump depletion effect has been included by employing the 1% criterion. This simulation can anticipate the Brillouin threshold gain value precisely. The threshold gain varies from 14 to 18 depending on the PCF length.     

Supercontinuum generation using a passive mode-locked stretched-pulse bismuth-based erbium-doped fiber laser

A Supercontinuum (SC) generation in photonic crystal fiber (PCF) is demonstrated using an amplified picosecond stretched-pulses from a passive mode-locked Bismuth-based Erbium-doped fiber laser (Bi-EDFL). The Bi-EDFL employs of a piece of a highly nonlinear 49 cm long Bismuth-based Erbium-doped fiber (Bi-EDF), an optical isolator and a polarization controller in a cavity to generate a mode-locked stretched-pulse via a nonlinear polarization rotation technique. It operates at 1560 nm with a repetition rate of 42 MHz and a pulse width of 131 fs. The SC lights, which extends from 1250 nm to 1910 nm as well as in the visible green wavelength region are obtained with a 100 m long PCF and the amplified pump power of 30 dBm.     

Microfiber Mach-Zehnder interferometer embedded in low index polymer

Microfiber Mach Zehnder Interferometer (MMZI) is demonstrated by micromanipulating an optical microfiber drawn from a single mode fiber (SMF) using a flame brushing technique. The MMZI shows good interference fringes with an extinction ratio of 13 dB and a free spectral range (FSR) of 0.52 nm at 1530 nm. The MMZI is then embedded in a polymer with the refractive index of 1.36 to increase the stability and robustnes of the device. It is found that the transmission spectrum of the packaged MMZI is changed by the polymer, which increases the FSR to 0.83 nm. The degradation in transmission loss and extinction ratio are attributed to the disturbance at the coupling area during the packaging. Compared with waveguide based mach zehnder interferometer, the proposed MMZI is favoured due to easy fabrication, compact size, and easy integration with the fiber system.     

Tunable laser generation with erbium-doped microfiber knot resonator

A tunable laser is demonstrated using a microfiber knot resonator structure made by erbiumdoped fiber (EDF). The laser is made of a 2 m long EDF where 30 mm of its end section is tapered to construct a microfiber knot resonator (MKR). The combination of the EDF and MKR generates a stable single wavelength laser at 1555 nm wavelength with a signal to noise ratio (SNR) of 33.7 dB using a 63 mW of 980 nm pump power. The peak wavelength of the laser can be tuned by 340 pm as the MKR diameter reduces from 5.0 to 0.5 mm with an acceptable penalty in output power.     

Performance comparison between plastic-based fiber bundle and multimode fused coupler as probes in displacement sensors

Fiber optic displacement sensors with bundled and fused coupler fiber probes are being investigated. The effects of axial displacements on the detected output voltages are also investigated for fiber bundle probe sensor. The resolutions obtained are 0.9 and 4.0 μm, for the front and back slopes, respectively. A comparison is made with a commercial plastic based multimode fused coupler which gives a better range of 2.0 mm. This is longer than that achieved by the fiber bundle probe which is only 0.4 mm and has a lower resolution of 34 μm for the case of 50:50 coupling ratio.     

Comparisons of multi-wavelength oscillations using Sagnac loop mirror and Mach-Zehnder interferometer for ytterbium doped fiber lasers

A multiwavelength Ytterbium-doped fiber ring laser operating at 1030 nm region is demonstrated using a Sagnac loop mirror and a Mach-Zehnder interferometer. We report the Performance comparisons of multi-wavelength oscillations in Yb³⁺ doped fiber lasers (YDFL) with typical commercial ytterbium doped silica fibers. By adjusting the polarization controller (PC), a widely tunable laser range of 22 nm from 1030 nm to 1050 nm is obtained. The Mach-Zehnder interferometer (MZI) design has exhibited simplicity in the operation for controlling the smallest wavelength spacing compared to Sagnac loop mirror method. In our observations, the smallest achieved stable wavelength spacing in Sagnac loop mirror setup and MZI setup were 2.1 nm and 0.7 nm, respectively. In case of nine-wavelength operation with a MZI setup, the stability, Full Width at Half Maximum (FWHM) and side mode suppression ratio (SMSR) of laser lines are not affected by increasing pump power, While for above four wavelength operation, the laser stability with Sagnac loop mirror becomes worse specially for higher input pump power and the power fluctuation among the wave-lengths would be also slightly larger.     

A linear cavity brillouin/bismuth-based erbium-doped fiber laser with enhanced characteristics

A new linear cavity BEFL configuration for increased Stokes-line generation is proposed and demonstrated utilizing a 2 × 2 coupler at the end of the linear cavity. The proposed linear cavity is able to generate up to 33 Stokes lines in the 1590-nm region at a channel spacing of 0.089 nm. The Stokes lines are generated at a BP power of 4 dBm and a 1480-nm pump power of 100 mW. The number of Stokes generated by the proposed BELF is higher compared to conventional BEFL configurations in which the 2 × 2 coupler is placed in the middle of the linear cavity. The number of Stokes lines generated is observed to depend on the 1480-nm pump power as well as the operating wavelength region, which must be as close as possible to the lasing bandwidth of the free-running BEFL. The proposed multiwavelength BEFL is able to operate stably at room temperatures and is also compact due to the use of a 215-cm bismuth-based EDF as the linear gain medium.     

Design,Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action

Our investigation includes the synthesis of new naphthalene-bis-triazole-bis-quinolin-2(1H)-ones 4a–e and 7a–e via Cu-catalyzed [3 + 2] cycloadditions of 4-azidoquinolin-2(1H)-ones 3a–e with 1,5-/or 1,8-bis(prop-2-yn-1-yloxy)naphthalene (2) or (6). All structures of the obtained products have been confirmed with different spectroscopic analyses. Additionally, a mild and versatile method based on copper-catalyzed [3 + 2] cycloaddition (Meldal–Sharpless reaction) was developed to tether quinolinones to O-atoms of 1,5- or 1,8-dinaphthols. The triazolo linkers could be considered as anti and syn products, which are interesting precursors for functionalized epidermal growth factor receptor (EGFR) inhibitors with potential apoptotic antiproliferative action. The antiproliferative activities of the 4a–e and 7a–e were evaluated. Compounds 4a–e and 7a–e demonstrated strong antiproliferative activity against the four tested cancer cell lines, with mean GI₅₀ ranging from 34 nM to 134 nM compared to the reference erlotinib, which had a GI₅₀ of 33 nM. The most potent derivatives as antiproliferative agents, compounds 4a, 4b, and 7d, were investigated for their efficacy as EGFR inhibitors, with IC₅₀ values ranging from 64 nM to 97 nM. Compounds 4a, 4b, and 7d demonstrated potent apoptotic effects via their effects on caspases 3, 8, 9, Cytochrome C, Bax, and Bcl2. Finally, docking studies show the relevance of the free amino group of the quinoline moiety for antiproliferative action via hydrogen bond formation with essential amino acids.