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201.
202.
The expression of high-abundance serum proteins in newly diagnosed patients with endometrial adenocarcinoma (EACa), squamous cell cervical carcinoma (SCCa) and cervical adenocarcinoma (ACCa), relative to control female subjects, was analyzed by subjecting serum samples to 2-DE followed by image analysis of the silver-stained protein profiles. The three cohorts of cancer patients demonstrated different altered expression of serum high-abundance proteins compared to negative control women. The expression of alpha1-antitrypsin, alpha1-B glycoprotein, cleaved high-molecular-weight kininogen (light chain) and antithrombin III were consistently altered in all the patients. However, clusterin was upregulated only in the patients with EACa, while those with SCCa and ACCa were typically characterized by the upregulated expression of zinc alpha-2-glycoprotein. The aberrant expression of selective serum proteins in the various cohorts of cancer patients was validated by competitive ELISA as well as by lectin detection. Analysis by using the champedak galactose binding lectin further highlighted an unidentified protein that may be differently glycosylated in the sera of the EACa patients that were studied. 相似文献
203.
Nour Fouz Azura Amid Yumi Zuhanis Has-Yun Hashim 《Applied biochemistry and biotechnology》2014,173(7):1618-1639
The contributing molecular pathways underlying the pathogenesis of breast cancer need to be better characterized. The principle of our study was to better understand the genetic mechanism of oncogenesis for human breast cancer and to discover new possible tumor markers for use in clinical practice. We used complimentary DNA (cDNA) microarrays to compare gene expression profiles of treated Michigan Cancer Foundation-7 (MCF-7) with recombinant bromelain and untreated MCF-7. SpringGene analysis was carried out of differential expression followed by Ingenuity Pathway Analysis (IPA), to understand the underlying consequence in developing disease and disorders. We identified 1,102 known genes differentially expressed to a significant degree (p?0.001) changed between the treatment. Within this gene set, 20 genes were significantly changed between treated cells and the control cells with cutoff fold change of more than 1.5. These genes are RNA-binding motif, single-stranded interacting protein 1 (RBMS1), ribosomal protein L29 (RPL29), glutathione S-transferase mu 2 (GSTM2), C15orf32, Akt3, B cell translocation gene 1 (BTG1), C6orf62, C7orf60, kinesin-associated protein 3 (KIFAP3), FBXO11, AT-rich interactive domain 4A (ARID4A), COPS2, TBPL1|SLC2A12, TMEM59, SNORD46, glioma tumor suppressor candidate region gene 2 (GLTSCR2), and LRRFIP. Our observation on gene expression indicated that recombinant bromelain produces a unique signature affecting different pathways, specific for each congener. The microarray results give a molecular mechanistic insight and functional effects, following recombinant bromelain treatment. The extent of changes in genes is related to and involved significantly in gap junction signaling, amyloid processing, cell cycle regulation by BTG family proteins, and breast cancer regulation by stathmin1 that play major roles. 相似文献
204.
Subash?C.?B.?GopinathEmail authorView authors OrcID profile Veeradasan?Perumal Balakrishnan?S.?Rao M.?K.?Md Arshad Chun?Hong?Voon Thangavel?Lakshmipriya R.?Haarindraprasad Thivina?Vijayakumar Yeng?Chen Uda?Hashim 《Mikrochimica acta》2017,184(10):3739-3745
The authors describe an electrochemical method for the determination of the blood clotting factor IX (FIX). A nanogapped dielectrode (with a < 100 nm junction) was modified with antibody against FIX, and the resulting system was characterized by both impedance spectroscopy and voltammetry. In order to attain the improved sensitivity, gold nanoparticles were electrostatically attached to FIX. The current to voltage (I-V) measurement was carried out from 1 V to 5 V, where the entire calibration plot with 5 V was taken. This results in a limit of detection as low of 1 pM, which is much lower compared to the real concentration of FIX (87 nM) in human blood serum. The analytical range extends from 1 pM to 0.1 μM. The electrode is highly specific over other serum proteins. 相似文献
205.
The prime objective of this article is to study the axisymmetric flow and heat transfer of the Carreau fluid over a radially stretching sheet. The Carreau constitutive model is used to discuss the characteristics of both shear-thinning and shear-thickening fluids. The momentum equations for the two-dimensional flow field are first modeled for the Carreau fluid with the aid of the boundary layer approximations. The essential equations of the problem are reduced to a set of nonlinear ordinary differential equations by using local similarity transformations. Numerical solutions of the governing differential equations are obtained for the velocity and temperature fields by using the fifth-order Runge–Kutta method along with the shooting technique. These solutions are obtained for various values of physical parameters. The results indicate substantial reduction of the flow velocity as well as the thermal boundary layer thickness for the shear-thinning fluid with an increase in the Weissenberg number, and the opposite behavior is noted for the shear-thickening fluid. Numerical results are validated by comparisons with already published results. 相似文献
206.
Ismayadi Ismail Mansor Hashim Khamirul Amin Matori Rosidah Alias Jumiah Hassan 《Journal of magnetism and magnetic materials》2012
Possible soaking-time effects on the magnetic and microstructural properties of polycrystalline samples of Ni0.5Zn0.5Fe2O4 have been studied. Nanosize powder produced by mechanical alloying was sintered at 800 °C with various soaking times. All samples showed the signature peak of Ni0.5Zn0.5Fe2O4 even with one hour of soaking time. The size distributions show a slow growth of microstructural evolution related to density, porosity and also to the magnetic hysteresis loops. Within these distributions it is observed that the formation of multi-domains is not possible and probably there are the regions of superparamagnetic and single-domain grains. From the permeability studies, it is believed that the rise of the magnetic moment on the B sites give rise to the total saturation magnetization with increase of soaking time. The hysteresis loop of one-hour soaking time showed paramagnetic behavior dominating while longer soaking times showed ferromagnetic behavior starting to dominate. The coercivity was observed to increase with soaking time, signaling the increase of the anisotropy fields which was attributed to the shape anisotropy and also to the magnetocrystalline anisotropy. By correlating the morphology, phase analysis, permeability and hysteresis loops results, it is believed that there was an increase in number of crystalline-growth regions which together formed a total mass of mixed superparamagnetic and ferromagnetic grains with the latter starting to dominate the samples. 相似文献
207.
A. Sami Bataineh M.S.M. Noorani I. Hashim 《Communications in Nonlinear Science & Numerical Simulation》2009,14(4):1121-1131
In this paper, approximate and/or exact analytical solutions of singular initial value problems (IVPs) of the Emden–Fowler type in the second-order ordinary differential equations (ODEs) are obtained by the homotopy analysis method (HAM). The HAM solutions contain an auxiliary parameter which provides a convenient way of controlling the convergence region of the series solutions. It is shown that the solutions obtained by the Adomian decomposition method (ADM) and the homotopy-perturbation method (HPM) are only special cases of the HAM solutions. 相似文献
208.
Samaila Bawa Waje Mansor Hashim Wan Daud Wan Yusoff 《Journal of magnetism and magnetic materials》2010,322(6):686-691
Co0.5Zn0.5Fe2O4 nanoparticles were prepared using mechanical alloying (MA) and sintering. The crystallite size, coercivity, retentivity and saturation magnetization were also measured. The frequency dependence of dielectric and the magnetic parameters, namely, real permittivity ε′, loss tanget tan δ, real permeability μ′ and loss factor μ″ were measured at room temperature for samples sintered from 600 to 1000 °C, in the frequency range 10 MHz to 1.0 GHz. The results show that the crystallite size of the resulting products ranges between 16 and 67 nm for as-milled sample and the sample sintered at 1000 °C, respectively. The sample sintered at 1000 °C, measured at room temperature exhibited a saturation magnetization of 37 emu g−1. The values of permittivity remain constant within the measured frequency, but vary with sintering temperature. The permeability values, on the other hand however vary with both the sintering temperature and the frequency, thus, the absolute value of the permeability decreased after the natural resonance frequency. 相似文献
209.
Muhammad Abid Saqib Jabbar Tao Wu Malik Muhammad Hashim Bing Hu Shicheng Lei Xin Zhang Xiaoxiong Zeng 《Ultrasonics sonochemistry》2013,20(5):1182-1187
Fresh apple juice treated with ultrasound (for 0, 30, 60 and 90 min, at 20 °C, 25 kHz frequency) was evaluated for different physico-chemical, Hunter color values, cloud value, antioxidant capacity, scavenging activity on 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, ascorbic acid, total phenolics, flavonoids, flavonols and microbial characteristics. No significant effect of sonication was observed on pH, total soluble solids (°Brix) and titratable acidity of apple juice. Sonication significantly improved ascorbic acid, cloud value, phenolic compounds, antioxidant capacity, DPPH free radical scavenging activity and differences in Hunter color values. Moreover, significant reduction in microbial population was observed. Findings of the present study suggested that sonication treatment could improve the quality of apple juice. It may successfully be employed for the processing of apple juice with improved quality and safety from consumer’s health point of view. 相似文献
210.
The superoxide ion electrochemically generated by reduction of oxygen, or chemically generated by dissolving potassium superoxide in ionic liquids, reacts with alkyl imidazolium cations of imidazolium-based ionic liquids at room temperature and atmospheric pressure to give the corresponding 2-imidazolones in excellent yields. 相似文献