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61.
Intramolecular Diels-Alder reactions of several N-O linked 4-vinylimidazole dimers provide the expected adduct in moderate to good yield as a single, all trans stereoisomer, along with smaller amounts of the inverse electron demand adduct. Oxidative rearrangement of the cycloadducts occurs on treatment with Davis' reagent, providing a single spiro imidazolone in good yield and with excellent levels of stereocontrol albeit epimeric at the spiro center found in axinellamine and massadine. 相似文献
62.
A rapid liquid chromatographic-electrospray ionisation ion trap mass spectrometry (LC-ESI-ITMS) method has been developed for the routine analysis of eight of the most oenologically important biogenic amines in wine without any sample pre-treatment. The method involves addition of heptylamine as an internal standard (IS) and the direct injection of filtered wine samples previously diluted with ultra high purity (UHP) water. The full-scan MS-MS spectra and the identical retention times to those of reference standards were used for unequivocal identification of the analytes. For most amines, the most abundant ions were derived from the loss of an ammonia group, while in the case of spermine and the I.S. the major product ions arose from the loss of 1,3-propyldiamine and the production of adduct with water, respectively. Detection was achieved in positive ionisation with an ion trap mass spectrometer operating in multiple-reaction monitoring (MRM) mode. The method allowed accurate determination of the analytes in the range 0.5-40 ng mL−1. Within-day and between-day relative standard deviation percentages were <8% and <12%, respectively. The overall process was successfully applied to identify and quantify biogenic amines in Rioja red wines. The new method is sensitive, rapid, cheap and less labour intensive. 相似文献
63.
de Almeida MV Teixeira FM de Souza MV Amarante GW Alves CC Cardoso SH Mattos AM Ferreira AP Teixeira HC 《Chemical & pharmaceutical bulletin》2007,55(2):223-226
Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83-94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-alpha production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups. 相似文献
64.
Nora N. Nichio Mónica L. Casella Osmar A. Ferretti 《Reaction Kinetics and Catalysis Letters》1999,66(1):27-32
In this paper the activity, selectivity and mainly stability of nickel catalysts in the oxyreforming reaction are analyzed.
The catalysts were prepared employing different precursors (nickel nitrate and nickel acetylacetonate) on α-Al2O3 and α-Al2O3 modified by a layer of aluminium oxide. The catalytic sample obtained from nickel acetylacetonate on the modified support
showed the best stability. 相似文献
65.
66.
Background
N-methyl-D-aspartate receptors (NMDARs) are the most complex of ionotropic glutamate receptors (iGluRs). Subunits of this subfamily assemble into heteromers, which – depending on the subunit combination – may display very different pharmacological and electrophysiological properties. The least studied members of the NMDAR family, the NR3 subunits, have been reported to assemble with NR1 to form excitatory glycine receptors in heterologous expression systems. The heterogeneity of NMDARs in vivo is in part conferred to the receptors by splicing of the NR1 subunit, especially with regard to proton sensitivity. 相似文献67.
Surface complexation mechanism and modeling in Cr(III) biosorption by a microalgal isolate, Chlorella miniata 总被引:2,自引:0,他引:2
The mechanism involved in the removal of Cr(III) by a green microalgal isolate, Chlorella miniata, was examined based on a series of batch experiments and microscopic analyses, and a mathematical model was proposed. Results showed that Cr(III) biosorption increased with the increase of pH from 2.0 to 4.5, and no significant changes in biosorption outside this pH range. Langmuir isotherm indicated that the maximum Cr(III) sorption capacity of Chlorella miniata was 14.17, 28.72, and 41.12 mg g(-1) biomass at pH 3.0, 4.0, and 4.5, respectively. Results from desorption studies, SEM (scanning electron microscopy), TEM (transmission electron microscopy), and EDX (energy-dispersive X-ray spectroscope) analyses confirmed that surface complexation was the main process involved in Cr(III) biosorption. Potentiometric titration revealed that carboxyl (pKa1 = 4.10), phosphonate (pKa2 = 6.36) and amine (pKa3 = 8.47) functional groups on the surface of Chlorella miniata were the possible sites for Cr uptake, and their average amounts were 0.53, 0.39, and 0.36 mmol g(-1) biomass, respectively. A surface complexation model further indicated that carboxyl group played the main role in Cr(III) complexation, with a binding constant of K11 = 1.87 x 10(-4) and K12 = 6.11 x 10(-4) for Cr3+ and Cr(OH)2+, respectively. This model also suggested that the hydroxy species was more easily to complex with the cell surface of Chlorella miniata. 相似文献
68.
Mondragón-Parada ME Nájera-Martínez M Juárez-Ramírez C Galíndez-Mayer J Ruiz-Ordaz N Cristiani-Urbina E 《Applied biochemistry and biotechnology》2006,134(3):223-232
The main purpose of this work was to isolate and characterize lactic acid bacteria (LAB) strains to be used for biomass production using a whey-based medium supplemented with an ammonium salt and with very low levels of yeast extract (0.25 g/L). Five strains of LAB were isolated from naturally soured milk after enrichment in whey-based medium. One bacterial isolate, designated MNM2, exhibited a remarkable capability to utilize whey lactose and give a high biomass yield on lactose. This strain was identified as Lactobacillus casei by its 16S rDNA sequence. A kinetic study of cell growth, lactose consumption, and titratable acidity production of this bacterial strain was performed in a bioreactor. The biomass yield on lactose, the percentage of lactose consumption, and the maximum increase in cell mass obtained in the bioreactor were 0.165 g of biomass/g of lactose, 100%, and 2.0 g/L, respectively, which were 1.44, 1.11, and 2.35 times higher than those found in flask cultures. The results suggest that it is possible to produce LAB biomass from a whey-based medium supplemented with minimal amounts of yeast extract. 相似文献
69.
Irina Piazza Antonio Cupane Emmanuel L. Barbier Claire Rome Nora Collomb Jacques Ollivier Miguel A. Gonzalez Francesca Natali 《Frontiers of Physics》2018,13(1):138301
With the aim of studying the effect of water dynamics on the properties of biological systems, in this paper, we present a quasi-elastic neutron scattering study on three different types of living cells, differing both in their morphological and tumor properties. The measured scattering signal, which essentially originates from hydrogen atoms present in the investigated systems, has been analyzed using a global fitting strategy using an optimized theoretical model that considers various classes of hydrogen atoms and allows disentangling diffusive and rotational motions. The approach has been carefully validated by checking the reliability of the calculation of parameters and their 99% confidence intervals. We demonstrate that quasi-elastic neutron scattering is a suitable experimental technique to characterize the dynamics of intracellular water in the angstrom/picosecond space/time scale and to investigate the effect of water dynamics on cellular biodiversity. 相似文献
70.
Doaa A. Osman Mario A. Macías Lamya H. Al-Wahaibi Nora H. Al-Shaalan Luke S. Zondagh Jacques Joubert Santiago Garcia-Granda Ali A. El-Emam 《Molecules (Basel, Switzerland)》2021,26(17)
The solid-state structural analysis and docking studies of three adamantane-linked 1,2,4-triazole derivatives are presented. Crystal structure analyses revealed that compound 2 crystallizes in the triclinic P-1 space group, while compounds 1 and 3 crystallize in the same monoclinic P21/c space group. Since the only difference between them is the para substitution on the aryl group, the electronic nature of these NO2 and halogen groups seems to have no influence over the formation of the solid. However, a probable correlation with the size of the groups is not discarded due to the similar intermolecular disposition between the NO2/Cl substituted molecules. Despite the similarities, CE-B3LYP energy model calculations show that pairwise interaction energies vary between them, and therefore the total packing energy is affected. HOMO-LUMO calculated energies show that the NO2 group influences the reactivity properties characterizing the molecule as soft and with the best disposition to accept electrons. Further, in silico studies predicted that the compounds might be able to inhibit the 11β-HSD1 enzyme, which is implicated in obesity and diabetes. Self- and cross-docking experiments revealed that a number of non-native 11β-HSD1 inhibitors were able to accurately dock within the 11β-HSD1 X-ray structure 4C7J. The molecular docking of the adamantane-linked 1,2,4-triazoles have similar predicted binding affinity scores compared to the 4C7J native ligand 4YQ. However, they were unable to form interactions with key active site residues. Based on these docking results, a series of potentially improved compounds were designed using computer aided drug design tools. The docking results of the new compounds showed similar predicted 11β-HSD1 binding affinity scores as well as interactions to a known potent 11β-HSD1 inhibitor. 相似文献