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131.
A rapid procedure, based on closed vessels microwave digestion and inductively coupled plasma-mass spectrometry (ICP-MS), was evaluated to ascertain the effect of chronic exposure to cadmium on intracellular accumulation of minor and essential trace elements in cultured epithelial cells (Caco-2 TC7). For all measurements, the method of external calibration was used and 3 elements (Be, Sc, In) were selected as internal standards. Optimization procedures are discussed and results are presented for the total determination of 9 key analytes (Na, Mg, Ca, Cr, Mn, Cu, Zn, Mo, and Cd) in certified reference materials (CRMs) and 20 samples of Caco-2 TC7 cells long-term exposed to Cd. The performance characteristics of the analytical system were evaluated by calibration and linearity, limits of detection and quantitation, accuracy with spiking, trueness and repeatability with available CRMs. As a complement to the ICP-MS determinations, both available CRMs and cell samples were analyzed either by electro thermal- or flame atomic absorption spectrometry. The results were in good agreement with the ICP-MS results. 相似文献
132.
133.
A concise and versatile method for the preparation of 3-aminoindoles from 2-(disubstituted amino)-benzonitriles is described, and in situ functionalizations were illustrated. 相似文献
134.
Smolders A De Martino F Staeren N Scheunders P Sijbers J Goebel R Formisano E 《Magnetic resonance imaging》2007,25(6):860-868
In combination with cognitive tasks entailing sequences of sensory and cognitive processes, event-related acquisition schemes allow using functional MRI to examine not only the topography but also the temporal sequence of cortical activation across brain regions (time-resolved fMRI). In this study, we compared two data-driven methods--fuzzy clustering method (FCM) and independent component analysis (ICA)--in the context of time-resolved fMRI data collected during the performance of a newly devised visual imagery task. We analyzed a multisubject fMRI data set using both methods and compared their results in terms of within- and between-subject consistency and spatial and temporal correspondence of obtained maps and time courses. Both FCM and spatial ICA allowed discriminating the contribution of distinct networks of brain regions to the main cognitive stages of the task (auditory perception, mental imagery and behavioural response), with good agreement across methods. Whereas ICA worked optimally on the original time series, averaging with respect to the task onset (and thus introducing some a priori information on the stimulation protocol) was found to be indispensable in the case of FCM. On averaged time series, FCM led to a richer decomposition of the spatio-temporal patterns of activation and allowed a finer separation of the neurocognitive processes subserving the mental imagery task. This study confirms the efficacy of the two examined methods in the data-driven estimation of hemodynamic responses in time-resolved fMRI studies and provides empirical guidelines to their use. 相似文献
135.
Pyrimidinium beta?nes (1), readily accessible via a straightforward modular synthesis from a formamidine and a monosubstituted malonic acid, are readily deprotonated by nBuLi (or KHMDS) to give the stable carbene species [2]Li+ (abbreviated as maloNHC). The latter represents the archetype of a subgroup of N-heterocyclic carbenes incorporating a malonate as remote anionic functional group within their heterocyclic backbone. While playing the dual role of monodentate 2 e- L type donor and noncoordinating charge carrier X, such ligands are seen to provide a rational route to zwitterionic complexes, as illustrated here by three examples (Rh, Fe, Ag). In particular, the reaction of [2]Li+ with [RhCl(1,5-COD)]2 produces the neutral 14 e- complex Rh(maloNHC)(COD) (3) in which coordinative unsaturation at the metal is relieved in the solid state by an uncommon labile bonding interaction between the Cipso of one of the mesityl arms and the Rh center. 相似文献
136.
Leen V Miscoria D Yin S Filarowski A Ngongo JM Van der Auweraer M Boens N Dehaen W 《The Journal of organic chemistry》2011,76(20):8168-8176
1,7-Dihalogenated boron dipyrromethene dyes were successfully synthesized and substituted, thus providing an entry to the final, elusive reactivity pattern. The spectroscopic properties of 1,7-disubstituted BODIPY dyes were studied and are discussed as a function of their structure. 相似文献
137.
138.
M. Gueye T. Gries C. Noël S. Migot-Choux S. Bulou E. Lecoq P. Choquet K. Kutasi T. Belmonte 《Plasma Chemistry and Plasma Processing》2016,36(4):1031-1050
The interaction of (3-Aminopropyl)triethoxysilane (APTES) with pulsed late Ar–O2 afterglow is characterized by the synthesis of OH, CO and CO2 in the gas phase as main by-products. Other minor species like CH, CN and C2H are also produced. We suggest that OH radicals are produced in a first step by dehydrogenation of APTES after interaction with oxygen atoms. In a second step, the molecule is oxidized by any O2 state, to form peroxides that transform into by-products, break thus the precursor C–C bonds. If oxidation is limited, i.e. a low duty cycle, fragmentation of the precursor is limited and produced nanoparticles keep the backbone structure of the precursor, but contain amide groups produced from the amine groups initially available in APTES. At high duty cycle, silicon-containing fragments contain some carbon and react together and produce nanoparticles with a non-silica-like structure. 相似文献
139.
Elias Vervecken Michel Van Overschelde Timothy Noël Yaşar Gök Susana Alvárez Rodríguez Simon Cogen Johan Van der Eycken 《Tetrahedron: Asymmetry》2010,21(19):2321-2328
Various chiral ligands bearing phosphorus or nitrogen donor atoms were obtained in a straightforward manner starting from trans-(2R,3R)-diphenylcyclopropane-1,1-dimethanol as a key structure. These chiral ligands were tested and compared in palladium(0)-catalyzed asymmetric allylic alkylation reactions (up to 71% ee) and rhodium(I)-catalyzed asymmetric hydrogenations (up to 88% ee). Moreover, in the asymmetric allylic alkylation, we observed excellent activity with a diphosphinite ligand (TOF = 600 mol 17 × [mol Pd × h)?1]. 相似文献
140.
Belén Altava M. Isabel Burguete Noèlia Carbó Jorge Escorihuela Santiago V. Luis 《Tetrahedron: Asymmetry》2010,21(8):982-989
A family of bis(amino amides) derived from natural amino acids has been synthesized and tested for the NMR enantiodiscrimination, as chiral solvating agents, for enantiomeric excess determination of some carboxylic acids. Those bis(amino amide) receptors contain different structural modifications and the splitting of the signals of the acids, after addition of the corresponding CSAs, depends on those structural variables. The influence of aminoacid side chain and the nature of the aliphatic spacer are important parameters to obtain good chiral discriminations. The results obtained clearly show the chiral recognition abilities of these bis(amino amide) ligands and suggest their advantageous use as chiral solvating agents for carboxylic acids. The binding between bis(amino amides) and carboxylic acids has been studied by ESI-MS, NMR, DSC, and molecular modeling. The data suggest that enantiodiscrimination involves the formation of an ionic pair after proton transfer from the carboxylic substrate to the bis(amino amides). 相似文献