全文获取类型
收费全文 | 91篇 |
免费 | 0篇 |
专业分类
化学 | 78篇 |
晶体学 | 1篇 |
力学 | 2篇 |
综合类 | 3篇 |
数学 | 3篇 |
物理学 | 4篇 |
出版年
2022年 | 3篇 |
2021年 | 1篇 |
2020年 | 4篇 |
2019年 | 1篇 |
2017年 | 4篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 1篇 |
2013年 | 6篇 |
2012年 | 5篇 |
2011年 | 4篇 |
2010年 | 4篇 |
2009年 | 4篇 |
2008年 | 4篇 |
2007年 | 5篇 |
2006年 | 3篇 |
2005年 | 2篇 |
2004年 | 1篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2001年 | 6篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1993年 | 1篇 |
1991年 | 3篇 |
1988年 | 1篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
排序方式: 共有91条查询结果,搜索用时 31 毫秒
11.
Niyaz Ahmad 《液相色谱法及相关技术杂志》2017,40(13):677-690
The aim of this study was to investigate the brain targeting potential of rasagiline-encapsulated chitosan-coated PLGA nanoparticles (RSG-CS-PLGA-NPs) delivered intranasally into the brain. Chitosan-coated PLGA nanoparticles (RSG-CS-PLGA-NPs) were developed through double emulsification-solvent evaporation technique. RSG-CS-PLGA-NPs were characterized for particle size, zeta potential, size distribution, encapsulation efficiency, and in vitro drug release. The mean particle size, polydispersity index, and encapsulation efficiency were found to be 122.38?±?3.64, 0.212?±?0.009, and 75.83?±?3.76, respectively. High-performance liquid chromatography–mass spectroscopy and mass spectroscopy study showed a significantly high mucoadhesive potential of RSG-CS-PLGA-NPs and least for conventional and homogenized nanoformulation. Pharmacokinetic results of RSG-CS-PLGA-NPs in Wistar rat brain and plasma showed a significantly high (**p?<?0.005) AUC0-24 and amplified Cmax over intravenous treatment group. Finally, the investigation demonstrated that intranasal delivery of mucoadhesive nanocarrier showed significant enhancement of bioavailability in brain, after administration of the RSG-CS-PLGA-NPs which could be a substantial achievement of direct nose to brain targeting in Parkinson’s disease therapy and related brain disorders. 相似文献
12.
M. Niyaz Ahamad Rahul Vaish K. B. R. Varma 《Journal of Thermal Analysis and Calorimetry》2011,105(1):239-243
Glasses of the composition 2TeO2–V2O5 were fabricated via the conventional melt-quenching technique. The amorphous and the glassy nature of the as-quenched samples
were confirmed by X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC), respectively. The glass transition
and crystallization parameters were evaluated under non-isothermal conditions using DSC. X-ray diffraction studies confirmed
the presence of partially oriented crystallites in the heat-treated glasses. Kauzmann temperature (lower bound for the kinetically
observed glass transition) was deduced from the heating rate dependent glass transition and crystallization temperatures. 相似文献
13.
The values of pseudo first‐order rate constants (kobs) for the cleavage of N‐(2‐hydroxyphenyl)phthalamic acid ( 7 ), obtained at 4.9 × 10?2 M HCl, 35°C, and within CH3CN content range 2–80% (v/v) in mixed aqueous solvent are smaller than kobs for the cleavage of N‐(2‐methoxyphenyl)phthalamic acid ( 8 ), obtained under almost similar experimental conditions, by nearly 1.5‐ to 2‐fold. These observations show the absence of expected intramolecular general acid catalysis due to 2‐OH group in 7 . The values of kobs for the cleavage of 7 and 8 decrease by more than 20‐fold with the increase in the content of CH3CN from 2 to 80–82% (v/v) in mixed aqueous solvent. The kinetic data reveal that in acidic aqueous cleavage of 7 , N‐cyclization (leading to the formation of imide) and O‐cyclization (leading to the formation of phthalic anhydride) vary from ~10 to 15% and ~90 to 85%, respectively, with the increase in CH3CN content from 2 to 80% (v/v). Similar increase in CH3CN content causes increase in N‐cyclization from ~0 to 5% and decrease in O‐cyclization from ~100 to 95% in the acidic aqueous cleavage of 8 . Some speculative, yet conceivable, reasons for nearly 10 and 0% N‐cyclization in the cleavage of respective 7 and 8 at low content of CH3CN have been described. © 2006 Wiley Periodicals, Inc. Int J Chem Kinet 38: 746–758, 2006 相似文献
14.
In aqueous methylamine buffers of pH 10.21–11.25 nucleophilic cleavage of ionized (S–) phthalimide and general base-catalyzed cleavage of nonionized (SH) phthalimide is observed. 相似文献
15.
Rizwan Ahmad Niyaz Ahmad Muhammad Riaz Maria Al-tarouti Fatimah Aloufi Alaa AlDarwish Bayan Alalaq Badriah Alhanfoush Zahid Khan 《Biomedical chromatography : BMC》2020,34(11):e4942
A range of conventional, i.e. maceration, percolation, ultrasonic assisted, Soxhlet and Soxtec extraction (STE), to advanced extraction techniques of accelerated solvent extraction (ASE) was utilized for the first time in order to optimize the extract yield and recovery of phenolics—gallic acid (GA), rutin (RT) and quercetin (QT)—quantified via ultra-high performance liquid chromatography with diode array detector (UHPLC–DAD). The effect of solvents (n-hexane, dichloromethane and methanol) and temperature (60, 80 and 100°C) upon extraction yield, phenolic content and antioxidant activity (DPPH, ABTS and DPPH) was studied, and the method was validated in commercial food samples from Saudi Arabia, China and India. A high extract yield with percentage recovery was observed for STE (1221.10 mg/5 g; 24.42%) and ASE techniques (91.50 mg/1 g; 9.15%) in methanol at 100°C. UHPLC–DAD showed retention times (min) of 0.67, 1.93 and 1.90 for GA, RT and QT, respectively in the shortest runtime of 3 min. The yield for phenolics was higher for STE/ASE (ppm): 15.27/15.29 (GA), 85.24/37.56 (RT) and 52.20/33.40 (QT), respectively. In terms of antioxidant activities, low IC50 values (μg/ml) of 1.09/1.18 (DPPH), 2.11/5.32 (ABTS) and 4.35/7.88 (phenazine methosulfate–nicotinamide adenine dinucleotide) were observed for STE and ASE, respectively. Multivariate analysis for STE showed a significant (P = 0.000) correlation for extraction type vs. extract yield and phenolics content; however, there was no significance for antioxidant activities vs. extraction type. ASE showed a positive correlation for solvent vs. extraction yield, phenolics and antioxidant activity; however, there was no correlation for extraction yield and DPPH activity. Principal component analysis for STE showed a major variability (52.02%) for extraction yield and phenolics in PC1 followed by PC2 (38.30%) for antioxidant activities. For ASE, PC1 (48.68%) showed a positive correlation for solvent vs. extraction yield and phenolics while PC2 (33.12%) showed a positive correlation for temperature and antioxidant activities. STE and ASE were the optimized extraction techniques for the garlic food sample while a significant effect of solvent and temperature was observed upon extraction yield, phenolics and antioxidant activity. 相似文献
16.
Apparent second-order rate constants (k(n)(app)) for the nucleophilic reaction of aniline (Ani) with phthalic anhydride (PAn) vary from 6.30 to 7.56 M(-1) s(-1) with the increase of temperature from 30 to 50 degrees C in pure glacial acetic acid (AcOH). However, the values of pseudo-first-order rate constants (k(s)) for the acetolysis of PAn in pure AcOH increase from 16.5 x 10(-4) to 10.7 x 10(-3) s(-1) with the increase of temperature from 30 to 50 degrees C. The values of k(n)(app) and k(s) vary from 5.84 to 7.56 M(-1) s(-1) and from 35.1 x 10(-4) to 12.4 x 10(-4) s(-1), respectively, with the increase of CH(3)CN content from 1% to 80% v/v in mixed AcOH solvents at 35 degrees C. The plot of k(s) versus CH(3)CN content shows a minimum (with 10(4) k(s) = 4.40 s(-1)) at 50% v/v CH(3)CN. Similarly, the variations of k(n)(app) and k(s) with the increasing content of tetrahydrofuran (THF) in mixed AcOH solvent reveal respective a maximum (with k(n)(app) = 17.5-15.6 M(-1) s(-1)) at 40-60% v/v THF and a minimum (with k(s) = approximately 0-1.2 x 10(-4) s (-1)) at 60-70% v/v THF. The respective values of DeltaH* and DeltaS* are 15.3 +/- 1.2 kcal mol(-1) and -20.1 +/- 3.8 cal K(-1) mol(-1) for k(s) and 1.1 +/- 0.5 kcal mol(-1) and -51.2 +/- 1.7 cal K(-1) mol(-1) for k(n)(app), while the values of k(n) (= k(n)(app)/f(b) with f(b) representing the fraction of free aniline base) are almost independent of temperature within the range 30-50 degrees C. A spectrophotometric approach has been described to determine f(b) in AcOH as well as mixed AcOH-CH(3)CN and AcOH-THF solvents. Thus, the observed data, obtained under different reaction conditions, have been explained quantitatively. An optimum reaction condition, within the domain of present reaction conditions, has been suggested for the maximum yield of the desired product, N-phenylphthalamic acid. 相似文献
17.
A highly sensitive ultra high pressure liquid chromatography (UHPLC‐MSMS) method for estimation of ropinirole in rat brain homogenate and plasma has been validated. The method was successfully used for the degradation kinetics in different stress condition and regulated temperature. The chromatographic separation was achieved using isocratic mobile phase, consisting of acetonitrile–2mM ammoniumacetate (28:72 v/v; 0.25 mL min?1). The mass spectrometer was operated in synapt mass spectrometry mode via positive electrospray ionization using the transitions m/z 260 → m/z 261 for ropinirole, and m/z 324.39 → m/z 262.161 as a parent ion of escitalopram (IS). The assay for ropinirole was linear over the range of 0.5–100 ng mL?1 (r2; 0.999). The intra‐ and inter day precisions were less than 11.2% in terms of relative standard deviation (R.S.D.), and the accuracy was within ±6.4% in terms of relative error (RE). The mean extraction‐efficiency of QC samples (MQC, 8 ng/mL) was ≥80%. The lower limit of quantification (LLOQ) was 0.049 ng/mL where as lower limit of detection (LLOD) was 0.016 ng/mL. All the peaks of degradation were well resolved. The degradation kinetics of ropinirole, showed highest stability (t1/2 256.66/h; t0.9, 39.11/h) in acidic medium, lower stability in alkaline environment (t1/2, 103.43/h; t0.9, 15.76/h) and highly susceptible in oxidative environment (t1/2, 21.58/h; t0.9, 3.28/h). The applicability of this assay was demonstrated and successfully applied for pharmacokinetic profiling of ropinirole in Wister rat brain homogenate after intranasal administration. 相似文献
18.
主要研究工作休假和休假中止的M/G/1排队系统,首先将对应于此系统的数学模型转化为抽象Cauchy问题,其次证明对应于此排队模型的主算子生成正压缩C0半群T(t),然后证明T(t)是局部等距的,最后证明此模型存在唯一的非负时间依赖解。 相似文献
19.
本文将证券价格时间序列分解成趋势变动序列和 Markov链 ,建立了证券组合的 Markov链模型 ,应用 Markov链理论对此模型进行了分析 ,给出了充分大的一个时间内的收益率 ,风险和切点组合的计算公式 相似文献
20.
M. Niyaz Khan 《国际化学动力学杂志》1988,20(6):443-454
The first-order rate constants, k1, for 1,2-ethanediolysis (within the content of 1,2-ethanediol of 5% to 90%, v/v) and 2-ethoxyethanolysis (within the 2-ethoxyethanol content of 5% to 60%, v/v) of phenyl salicylate, PSH, in alkaline aqueous mixed solvents, fit to a relationship: k1 = k[ROH]T/(1 + K[ROH]T) where k and K represent the secondorder rate constant for the reaction of alkanol, ROH, with ionized phenyl salicylate, PS?, and association constant for the dimerization of ROH, respectively, and [ROH]T is the total concentration of ROH. Similar relationship between k1 and [ROH]T has been found for 1,2-ethanediolysis of PS? studied in mixed solvents containing 1,2-ethanediol and MeCN. In the alkaline aqueous mixed solvents containing 2-ethoxyethanol, the k1-[ROH]T profile reveals the change in the solvent structure of the reaction medium at >60% (v/v) of ROH content. It is proposed that alkanols exist in polymeric form, (ROH)n, and the alkanolysis of PS? involves the pre-equilibrium formation of monomeric ROH from (ROH)n, followed by an intramolecular general base-catalyzed nucleophilic attack at carbonyl carbon of ester. A slight negative KCl salt- and slight positive n-Bu4NI salt-effect are obtained for 1,2-ethanediolysis while a significant positive n-Bu4NI salt-effect is obtained for 2-ethoxyethanolysis of PS?. 相似文献