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51.
Nurul Akmaryanti Abdullah Nur Fariesha Md Hashim Aula Ammar Noraina Muhamad Zakuan 《Molecules (Basel, Switzerland)》2021,26(4)
Cancer is one of the leading causes of death worldwide, with a mortality rate of more than 9 million deaths reported in 2018. Conventional anti-cancer therapy can greatly improve survival however treatment resistance is still a major problem especially in metastatic disease. Targeted anti-cancer therapy is increasingly used with conventional therapy to improve patients’ outcomes in advanced and metastatic tumors. However, due to the complexity of cancer biology and metastasis, it is urgent to develop new agents and evaluate the anti-cancer efficacy of available treatments. Many phytochemicals from medicinal plants have been reported to possess anti-cancer properties. One such compound is known as oridonin, a bioactive component of Rabdosia rubescens. Several studies have demonstrated that oridonin inhibits angiogenesis in various types of cancer, including breast, pancreatic, lung, colon and skin cancer. Oridonin’s anti-cancer effects are mediated through the modulation of several signaling pathways which include upregulation of oncogenes and pro-angiogenic growth factors. Furthermore, oridonin also inhibits cell migration, invasion and metastasis via suppressing epithelial-to-mesenchymal transition and blocking downstream signaling targets in the cancer metastasis process. This review summarizes the recent applications of oridonin as an anti-angiogenic and anti-metastatic drug both in vitro and in vivo, and its potential mechanisms of action. 相似文献
52.
Mohammed Ahmed Akkaif Nur Aizati Athirah Daud Abubakar Shaaban Mei Li Ng Muhamad Ali Sk Abdul Kader Dzul Azri Mohamed Noor Baharudin Ibrahim 《Molecules (Basel, Switzerland)》2021,26(7)
Clopidogrel is a widely-used antiplatelet drug. It is important for the treatment and prevention of coronary heart disease. Clopidogrel can effectively reduce platelet activity and therefore reduce stent thrombosis. However, some patients still have ischemic events despite taking the clopidogrel due to the alteration in clopidogrel metabolism attributable to various genetic and non-genetic factors. This review aims to summarise the mechanisms and causes of clopidogrel resistance (CR) and potential strategies to overcome it. This review summarised the possible effects of genetic polymorphism on CR among the Asian population, especially CYP2C19 *2 / *3 / *17, where the prevalence rate among Asians was 23.00%, 4.61%, 15.18%, respectively. The review also studied the effects of other factors and appropriate strategies used to overcome CR. Generally, CR among the Asian population was estimated at 17.2–81.6%. Therefore, our overview provides valuable insight into the causes of RC. In conclusion, understanding the prevalence of drug metabolism-related genetic polymorphism, especially CYP2C19 alleles, will enhance clinical understanding of racial differences in drug reactions, contributing to the development of personalised medicine in Asia. 相似文献
53.
Monatshefte für Chemie - Chemical Monthly - New azidosulfonamide–chalcone derivatives were designed and synthesized. Their structures were elucidated by 1H and 13C NMR spectral analyses,... 相似文献
54.
Saiful Izwan Abd Razak Farah Nuruljannah Dahli Izzati Fatimah Wahab Mohammed Rafiq Abdul Kadir Ida Idayu Muhamad Abdul Halim Mohd Yusof 《Soft Materials》2016,14(2):78-86
This paper reports for the first time a simple yet effective method for fabricating a conductive and highly porous scaffold material made up of polylactic acid (PLA) and conducting polyaniline (PANI). The electrical percolation state was successfully obtained at 3 wt% of PANI inclusions and reached a conductivity level of useable tissue engineering applications at 4 wt%. In addition, preliminary bioactivity test results indicated that the protonating agent could form a chelate at the scaffold surface leading to good in-vitro apatite forming ability during biomimetic immersion. This new conductive scaffold has potential as a suitable biomedical material that requires electrical conductivity. 相似文献
55.
Agus Muhamad Hatta Yuliya Semenova Ginu Rajan Gerald Farrell 《Optics & Laser Technology》2010,42(6):1044-1048
The polarization dependent loss (PDL) of a singlemode–multimode–singlemode (SMS) fibre structure used as an edge filter is presented. Minor errors in the fabrication process for the SMS fibre structure can introduce SMS fibre core offsets. The PDL due to lateral and rotational core offsets is investigated numerically and experimentally. It is shown that small core offsets are necessary to achieve low PDL for an SMS fibre based edge filter. It is also demonstrated that when lateral core offsets are unavoidable, the PDL of a SMS edge filter can still be minimized by introducing a rotational core offset of 90°. 相似文献
56.
Su Kong Chong Boon Tong Goh Yuen-Yee Wong Hong-Quan Nguyen Hien Do Ishaq Ahmad Zarina Aspanut Muhamad Rasat Muhamad Chang Fu Dee Saadah Abdul Rahman 《Journal of luminescence》2012,132(6):1345-1352
High density of silicon nanowires (SiNWs) were synthesized by a hot-wire assisted plasma enhanced chemical vapor deposition technique. The structural and optical properties of the as-grown SiNWs prepared at different rf power of 40 and 80 W were analyzed in this study. The SiNWs prepared at rf power of 40 W exhibited highly crystalline structure with a high crystal volume fraction, XC of ~82% and are surrounded by a thin layer of SiOx. The NWs show high absorption in the high energy region (E>1.8 eV) and strong photoluminescence at 1.73 to 2.05 eV (red–orange region) with a weak shoulder at 1.65 to 1.73 eV (near IR region). An increase in rf power to 80 W reduced the XC to ~65% and led to the formation of nanocrystalline Si structures with a crystallite size of <4 nm within the SiNWs. These NWs are covered by a mixture of uncatalyzed amorphous Si layer. The SiNWs prepared at 80 W exhibited a high optical absorption ability above 99% in the broadband range between 220 and ~1500 nm and red emission between 1.65 and 1.95 eV. The interesting light absorption and photoluminescence properties from both SiNWs are discussed in the text. 相似文献
57.
Wan Mohamad Ikhmal Wan Mohamad Kamaruzzaman Maria Fazira Mohd Fekeri Nursabrina Amirah Mohd Nasir Nur Aiman Syafiq Mohd Hamidi Mohamad Zahid Baharom Azila Adnan Muhamad Syaizwadi Shaifudin Wan Rafizah Wan Abdullah Wan Mohd Norsani Wan Nik Fariza Hanim Suhailin Khamirul Amin Matori Chen Soo Kien Mohd Hafiz Mohd Zaid Mohd Sabri Mohd Ghazali 《Molecules (Basel, Switzerland)》2021,26(11)
With the trend for green technology, the study focused on utilizing a forgotten herb to produce an eco-friendly coating. Andrographis paniculata or the kalmegh leaves extract (KLE) has been investigated for its abilities in retarding the corrosion process due to its excellent anti-oxidative and antimicrobial properties. Here, KLE was employed as a novel additive in coatings and formulations were made by varying its wt%: 0, 3, 6, 9, and 12. These were applied to stainless steel 316L immersed in seawater for up to 50 days. The samples were characterized and analyzed to measure effectiveness of inhibition of corrosion and microbial growth. The best concentration was revealed to be 6 wt% KLE; it exhibited the highest performance in improving the ionic resistance of the coating and reducing the growth of bacteria. 相似文献
58.
Khaulah Sulaiman Wan Haliza Abdul Majid Muhamad Rasat Muhamad 《Applied Surface Science》2006,252(8):2875-2881
The monolayer of organic molecules at the air-water interface has been studied using the Maxwell displacement current (MDC) technique. The materials used in this study were the biological materials of phosphatidyl ethanolamine (PE) and phosphatidic acids (PA). The configuration of the experimental set-up consists of the metal/air-gap/monolayer/metal coupled with the Langmuir method. This measurement enables the detection of current without destroying the monolayer. The phase transition and molecular orientation of the phospholipid monolayers were investigated using MDC measurement without mechanical contact between electrodes and the materials. Direct evidence of phase transition from gaseous to the polar ordering phase can be obtained across phospholipid monolayers even though at very low surface pressure. Relaxation process of the phospholipid monolayers was investigated by using the step compression on the MDC signals. 相似文献
59.
The electronic structure and stability of pyrrolyl are investigated using CASSCF, CASPT2 and G2(MP2) techniques. The ground state of pyrrolyl is found to be 2A2, with five π-electrons, as in cyclopentadienyl. The computed N–H bond energy of pyrrole is 94.8 kcal mol−1, while the heat of formation ΔfH298o of pyrrolyl is deduced to be 70.5±1 kcal mol−1. The Arrhenius parameters of N–H and C–H bond fission in pyrrole and cyclopentadiene and hydrogen abstraction reactions (by hydrogen) were also computed, indicating that pyrrolyl forms predominantly by C–H bond fission of pyrrolenine rather than by direct N–H bond fission. 相似文献
60.
H.H. Mansour S. per Khdar H.Y. Abdulla N.Q. Muhamad M.M. Othman S. Qader 《Radiation measurements》2005,40(2-6):544-547
Radon alpha activity concentration has been measured in 28 homes in the Erbil Capital-Iraqi Kurdistan region during the autumn season by using time-integrated passive radon dosimeters containing CR-39 solid state nuclear track detectors “SSNTDs”. The radon activity concentrations in these homes range from (10.33–90.34) with an average of . The average absorption effective dose equivalent for a person living in homes for which the investigation were done was found to be , obtained by using an equilibrium factor of 0.5 and an occupancy factor of 0.8. The average lung cancer cases per year per 106 person was found to be 23±12. 相似文献