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K absorption edge energies of Ag and Sn elements have been determined by using a weak beta source. In this method, the beta particles from a 90Sr? 90Y beta source interact with an iron foil to produce the external bremsstrahlung (EB) photons. The spectrum of EB photons is passed through the elemental target and the spectrum of transmitted photons is recorded with a high resolution HPGe detector spectrometer coupled to 16K multichannel analyzer. The recorded transmitted EB spectrum shows a sharp decrease in intensity at the K shell binding energy of elemental target. Such a sharp decrease region, which is corrected for Kβ′2 contribution, has been used to determine the K absorption edge energies of Ag and Sn elemental targets. The measured values have been compared with theoretical and experimental values. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
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Xi-Hua Cui Hosakatte Niranjana Murthy Kee-Yoeup Paek 《Applied biochemistry and biotechnology》2014,174(2):784-792
Hypericum perforatum L. (St. John’s Wort) is an important medicinal plant which is widely used in the treatment for depression and irritable bowel syndrome. It is also used as a dietary supplement. Major bioactive phytochemicals of H. perforatum are phenolics and flavonoids. Quality of these phytochemicals is dramatically influenced by environmental and biological factors in the field grown plants. As an alternative, we have developed adventitious root cultures in large-scale bioreactors for the production of useful phytochemicals. Adventitious roots of H. perforatum were cultured in 500 l pilot-scale airlift bioreactors using half-strength Murashige and Skoog medium with an ammonium and nitrate ratio of 5:25 mM and supplemented with 1.0 mg l?1 indole butyric acid, 0.1 mg l?1 kinetin, and 3 % sucrose for the production of bioactive phenolics and flavonoids. Then 4.6 and 6.3 kg dry biomass were realized in the 500 l each of drum-type and balloon-type bioreactors, respectively. Accumulation of 66.9 mg g?1 DW of total phenolics, 48.6 mg g?1 DW of total flavonoids, 1.3 mg g?1 DW of chlorogenic acid, 0.01 mg g?1 DW of hyperin, 0.04 mg g?1 DW of hypericin, and 0.01 mg g?1 DW of quercetin could be achieved with adventitious roots cultured in 500 l balloon-type airlift bioreactors. Our findings demonstrate the possibilities of using H. perforatum adventitious root cultures for the production of useful phytochemicals to meet the demand of pharmaceutical and food industry. 相似文献
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High Resolution Synchrotron Diffraction Study on Charge Density Distribution of Ampicillin Trihydrate
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C. Anzline S. Israel R. Niranjana Devi R. A. J. R. Sheeba P. Richard Rajkumar 《化学物理学报(中文版)》2017,30(1):50-62
Charge density distribution in ampicillin trihydrate was investigated experimentally. Results were compared with the quantum calculations using density functional theory. The charge derived properties including Mulliken atomic charges, dipole moment, and molecular electrostatic potential were calculated. The multipole analysis was done for the refinement of experimental population parameters. The structure factors obtained from multipole treatment were used for the construction of Fourier maps. Topological properties of the charge distribution were discussed and the characteristics of (3,-1) critical points were analyzed. 相似文献
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Devendar Ponnam Niranjana Kumar Arigari Satya Srinivas Kalvagunta Venkata Naga Kotesh Kumar Jonnala Shilpi Singh Abha Meena Pallavi Misra Suaib Luqman 《Journal of heterocyclic chemistry》2021,58(11):2090-2101
Biologically important three different pharmacophores, forskolin, indole and 1,2,3-triazoles are coupled to obtain a hybrid molecule. Here, we described the synthesis of novel series of forskolin-indole-triazole conjugates 5a-5l by using the Cu(I) catalyzed 1,3-dipolar cycloaddition reaction. Furthermore, the biological significance of the synthesized molecules was assessed by in silico and in vitro modes. All the synthesized compounds were evaluated for in vitro anticancer activity against PC-3, MCF-7, MDA-MB-231, COLO-205, HeLa, WRL-68, RAJI, CHANG and RAW-264.7 cell lines. Compound 5g was found to be the most potent in all the tested cell lines (IC50 range 9.6–21.66 μg/ml, except COLO-205), 5a, 5b and 5k were observed to exert its effect only against WRL-68 (IC50 range 27.69–48.18 μg/ml), when compared to parent 3 (IC50 > 100 μg/ml, tested concentrations 10–50 μg/ml) and standard Doxorubicin (IC50 range 0.42–3.16 μg/ml). The most potent compound 5g (MEF50 0.57) was found non-toxic to human erythrocytes as compared to control (MEF50 0.60) at tested concentration (50 μg/ml). In silico-based succinate dehydrogenase inhibition showed that the synthesized compounds were having potent binding affinity compared to forskolin. Predictive ADMET and toxicity risk assessment analysis revealed that most of the compounds were complying with the standard limit of Lipinski's rule of five for oral bioavailability. 相似文献
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Bastin K. Jose Athulya Simon Niranjana Subrahmanian P. Adhwithi Sindhu Mathai 《Journal of heterocyclic chemistry》2024,61(2):199-216
The versatile and convergent nature of 1,3-dipolar cycloaddition reactions has made them an indispensable tool in organic chemistry for synthesizing five-membered heterocycles. Among the various dipoles, azomethine imines (AMI) constitute a versatile class, increasingly used to synthesize biologically relevant heterocycles. The organocatalytic cycloaddition reactions of azomethine imines are relatively unexplored compared to the corresponding transition metal-catalyzed reactions. This review highlights the unique organocatalytic cycloaddition reactions of AMI with different dipolarophiles. The cycloaddition of azomethine imines catalyzed by organic bases such as prolinol, proline, alkaloids, 1,4-diazabicyclo[2.2.2]octane, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), primary amines, tertiary amines, N-heterocyclic carbene, and phosphine are discussed here. The mechanistic and electronic aspects, including broad functional group tolerance, catalyst loading, and reaction conditions, are evaluated. This review also demonstrates the scope and potential reactivity of azomethine imines in organocatalytic cycloadditions. We are positive that the reactions of azomethine imines discussed here will aid in discovering new and efficient reaction pathways in synthesizing biologically active and industrially relevant molecules. 相似文献
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Mannich aminomethylation products have been prepared from one-pot template condensation of bis(glycinato)metal(II) complexes, M(gly)2, with formaldehyde and nitromethane. The synthesized compounds were characterized by suitable spectroscopic and analytical methods such as UV–Vis, infrared spectroscopy, elemental analysis, FAB mass, ESR, cyclic voltammetry, TGA and NMR. One of the synthesized products has been used as catalyst in the hydrogen peroxide induced degradation of pyrocatechol violet (PCV) dye. 相似文献
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实验研究了氨苄青霉素三水合物的电荷密度分布,并与用密度泛函理论的量子计算结果进行比较.计算了电荷导出性质,Mulliken原子电荷,偶极矩和分子静电势.另外用多极分析对实验总体参数的进行细化.用多极处理获得的结构因子构建了傅立叶图.同时讨论电荷分布的拓扑性质,分析了(3,-1)临界点的特性. 相似文献
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Subrahmanian Supriya Aravamudhan Raghavan V.R. Vijayaraghavan Kandasamy Chinnakali Hoong-Kun Fun J. Subramanian 《Polyhedron》2007
Mannich aminomethylation reactions involving M(aa)2, where M = Cu, Ni and aa = glycine(gly), dl-alanine(dl-ala), l-alanine(l-ala), with formaldehyde and diethylmalonate have been carried out, resulting in carboxylate appended systems in high yield. All the compounds have been characterized by UV-Vis spectroscopy, infrared spectroscopy and elemental analysis. One of the synthesized complexes, (5,5-dicarboxyethyl-3,7-diazanonanedioato)copper(II) monohydrate, has been characterized by single crystal XRD and has been used as catalyst in the hydrogen peroxide-induced degradation of pyrocatechol violet (PCV) dye. The variations in the rate of degradation of the dye with respect to change in concentration of hydrogen peroxide, dye, catalyst and pH have been studied. Effect of addition of NaCl has been studied and a suitable mechanism based on the formation of free radical species during the degradation process has been proposed. 相似文献
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