Simple one-pot synthesis of 5-(chloromethyl)isoxazoles from aldoximes and 2,3-dichloro-1-propene

Chemistry of Heterocyclic Compounds - A one-pot synthesis of 3-substituted 5-chloromethylisoxazoles from available starting aldoximes and 2,3-dichloro-1-propene, serving both as a solvent and...     

Vinylbenziodoxol(on)es: Synthetic Methods and Applications

Cyclic hypervalent iodine reagents are now frequently used in synthetic organic chemistry, either as oxidants or group-transfer reagents. Vinylbenziodoxol(on)es (VBXs) bearing alkene substituents have been less investigated than the corresponding trifluoromethyl or alkynyl reagents. Nevertheless, since 2016 the development of new synthetic methods to access VBXs has awakened the interest of the synthetic community, leading to new transformations highlighting their unique reactivity as electrophilic alkene synthons. In this review, an overview of the synthesis and applications of VBX reagents will be presented. The review is organized according to the two main classes of VBX reagents reported so far – simple alkyl/aryl-substituted VBXs and heteroatom (S, O, N, X)-substituted VBXs – as they differ significantly from the point of view of synthetic access.     

Aluminum electrodeposition from a non-aqueous electrolyte—a combined computational and experimental study

Electrodeposition of aluminum (Al) from an organic non-aqueous electrolyte of ethylbenzene containing aluminum bromide is demonstrated. It is offered as a simple method for the preparation of Al coatings. This work employs distinct electrochemical techniques and explores the effects of the experimental parameters on the kinetics of the process and the quality of the final coatings. The process presented here enables deposition of pure and crystalline Al at room temperature and facilitates the production of uniform Al coatings on various metallic substrates. Morphological studies establish that the growth of Al deposits follows an island mode, and thus, the most noteworthy effect of the substrate over the morphology of the deposits originates from its impact over the nucleation stage, and the density of islands. This study is complemented by theoretical modeling for the adsorption of Al atoms at the different surfaces. Corrosion evaluation determines the dissolution mechanisms of each of the studied substrates in the examined electrolyte. These findings further corroborate the claim that this electrolyte enables the reversible electrodeposition of Al.

     

Photocatalytic properties of SnO2–SnO nanocomposite prepared via pulse alternating current synthesis

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Isoxazole derivatives of silatrane: synthesis,characterization, in silico ADME profile,prediction of potential pharmacological activity and evaluation of antimicrobial action

A new family of mono- ( 3a-h ) and bis- ( 4a-g ) isoxazole-bridged silatranes has been synthesized by the reaction of 3-aminopropylsilatrane ( 1 ) and 3-substituted 5-chloro-methylisoxazoles ( 2a-h ). The structure of the isoxazole-silatrane hybrids is characterized by elemental analysis, FT-IR, UV, NMR (¹H, ¹³C,²⁹Si and ¹⁵N) spectroscopy, high-resolution mass spectrometry, and X-ray diffraction analysis. The in silico ADME (absorption, distribution, metabolism, excretion) assessment reveals that properties of mono-adducts ( 3a-h ) are similar to those of drugs obeyed to the Lipinski's rule. The calculated screening of potential pharmacological activity profiles (in silico PASS program) of isoxazole-silatranes shows that all synthesized compounds (both mono- and bis-substituted) may have high antitumor action, unlike starting isoxazoles. The preliminary screening of the synthesized silatranes for antimicrobial activity against Enterococcus durans, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa indicates that all test samples are active only against gram-positive microorganisms. Silatrane 3f displays minimal inhibitory concentration (MIC 12.5 and 6.2 μg ml⁻¹) against E. durans and B. subtilis as compared with standard drug gentamicin (MIC 25 and 50 μg ml⁻¹).     

Single-stage synthesis of alkyl-H-phosphinic acids from elemental phosphorus and alkyl bromides

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FIm-modules over Noetherian rings

In this paper we study representation theory of the category ${\mathrm{FI}}^m$ introduced in [6], [7] which is a product of copies of the category FI, and show that quite a few interesting representation theoretic and homological properties of FI can be generalized to ${\mathrm{FI}}^m$ in a natural way. In particular, we prove the representation stability property of finitely generated ${\mathrm{FI}}^m$-modules over fields of characteristic 0.     

Crystal structure and spectral properties of Np(VI) and U(VI) methanesulfonates

Journal of Radioanalytical and Nuclear Chemistry - A new U(VI) complex with methanesulfonic acid was obtained [UO2(OH)(CH3SO3)]. Its crystal structure was determined using X-ray single crystal...