Catechol and amine residues, both abundantly present in mussel adhesion proteins, are known to act cooperatively by displacing hydration barriers before binding to mineral surfaces. In spite of synthetic efforts toward mussel-inspired adhesives, the effect of positioning of the involved functional groups along a polymer chain is not well understood. By using sequence-defined oligomers grafted to soft hydrogel particles as adhesion probes, we study the effect of catechol–amine spacing, as well as positioning relative to the oligomer terminus. We demonstrate that the catechol–amine spacing has a significant effect on adhesion, while shifting their position has a small effect. Notably, combinations of non-charged amides and catechols can achieve similar cooperative effects on adhesion when compared to amine and catechol residues. Thus, these findings provide a blueprint for the design of next generation mussel-inspired adhesives.The catechol driven adhesion of precision macromolecules on glass surfaces is quantified by soft colloidal probe readout. Catechol moieties are shown to synergize with amine and amide residues depending on residue spacing and residue order. 相似文献
The (exterior) oblique derivative problem of potential theory is considered where l is a C(1,λ)-vector field on a regular boundary ?Ge in Euclidean space R 3 and the direction l at any point of ?Ge forms with the outside normal n an angle ? (l, n) satisfying cos ? (l, n) ≥ c > 0. An approximation of the uniquely determined solution is given by use of trial functions {Φn}n=0,1,… harmonic in some region containing Ge and suitable for numerical purpose (for instance: solid spherical harmonics, certain sequences of fundamental solutions). The system {l▽Φn+hΦn}n=0,1,… defined on ?Ge is shown to be closed and complete in the pre-Hilbert space C(0,λ)(?Ge) of λ-Hölder continuous functions. 相似文献
Abstract The binding forms of Co, Cd, Cu, Pb, and Zn in an anoxic, sulfide-bearing sediment were investigated by performing both thermodynamic equilibrium calculations and sequential extractions. Care was taken to maintain oxygen-free conditions during the whole experiment. The calculations suggested that trace metals were bound to sulfidic minerals. Sequential extraction results, however, showed increased importance of exchangeable and reducible fractions in the order Cu < Cd < Pb < Zn < Co. Thermodynamic equilibrium calculations of the chemical reactions during extraction showed that Cd, Co, Pb, and Zn sulfides are to a significant extent soluble in the acetate-exchangeable (step 1 + 2) and oxalate-reducible (step 3) fractions. Neglecting the dissolution of sulfide minerals would lead to a misinterpretation of the experimental results. 相似文献