The synthesis, crystal structure, photophysical properties, and biological activity of the novel bis‐cyclometalated complexes [Ir(ptpy)2(vnsc)] ( 2 ) and [Ir(ptpy)2(acsc)] ( 3 ) [ptpy = 2‐(p‐tolyl)pyridinato, vnsc = vanillin semicarbazone, acsc = acetone semicarbazone] are described. The new compounds were prepared by the reaction of [{Ir(μ‐Cl)(ptpy)2}2] ( 1 ) with the corresponding semicarbazone ligands under basic conditions. The molecular structure of compound 3 was confirmed by a single‐crystal X‐ray diffraction study. The complex crystallized from chloroform as a mono‐ solvate in the orthorhombic space group Pcab with eight molecules in the unit cell. 相似文献
A series of imidazolium salts bearing two alkyl chains in the backbone of the imidazolium core were synthesized, resembling the structure of lipids. Their antibacterial activity and cytotoxicity were evaluated using Gram‐positive and Gram‐negative bacteria and eukaryotic cell lines including tumor cells. It is shown that the length of alkyl chains in the backbone is vital for the antibiofilm activities of these lipid‐mimicking components. In addition to their biological activity, their surface activity and their membrane interactions are shown by film balance and quartz crystal microbalance (QCM) measurements. The structure–activity relationship indicates that the distinctive chemical structure contributes considerably to the biological activities of this novel class of lipids. 相似文献
Today's olefin metathesis catalysts show high reactivity, selectivity, and functional group tolerance and allow the design of new syntheses of precisely functionalized polymers. Here the synthesis of a new end‐capping reagent is investigated allowing the introduction of a highly reactive activated ester end‐group at the polymer chain end as well as its prefunctionalization to directly introduce functional moieties. The versatility of this new end‐capping reagent is demonstrated by utilizing it to synthesize a so‐called termimer (a monomer with termination capabilities). Copolymerization of a norbornene derivative with the termimer leads to hyperbranched ring‐opening metathesis polymerization polymers as proven by gel permeation chromatography and MALDI‐ToF‐(matrix‐assisted laser desorption/ionization time of flight) mass spectrometry.
We are concerned with the existence of infinitely many solutions for the problem \(-\Delta u=|u|^{p-2}u+f\) in \(\Omega \), \(u=u_0\) on \(\partial \Omega \), where \(\Omega \) is a bounded domain in \(\mathbb {R}^N\), \(N\ge 3\). This can be seen as a perturbation of the problem with \(f=0\) and \(u_0=0\), which is odd in u. If \(\Omega \) is invariant with respect to a closed strict subgroup of O(N), then we prove infinite existence for all functions f and \(u_0\) in certain spaces of invariant functions for a larger range of exponents p than known before. In order to achieve this, we prove Lieb–Cwikel–Rosenbljum-type bounds for invariant potentials on \(\Omega \), employing improved Sobolev embeddings for spaces of invariant functions. 相似文献
Mesoporous materials as support for immobilized enzymes have been explored extensively during the last two decades, primarily not only for biocatalysis applications, but also for biosensing, biofuels and enzyme-controlled drug delivery. The activity of the immobilized enzymes inside the pores is often different compared to that of the free enzymes, and an important challenge is to understand how the immobilization affects the enzymes in order to design immobilization conditions that lead to optimal enzyme activity. This review summarizes methods that can be used to understand how material properties can be linked to changes in enzyme activity. Real-time monitoring of the immobilization process and techniques that demonstrate that the enzymes are located inside the pores is discussed by contrasting them to the common practice of indirectly measuring the depletion of the protein concentration or enzyme activity in the surrounding bulk phase. We propose that pore filling (pore volume fraction occupied by proteins) is the best standard for comparing the amount of immobilized enzymes at the molecular level, and present equations to calculate pore filling from the more commonly reported immobilized mass. Methods to detect changes in enzyme structure upon immobilization and to study the microenvironment inside the pores are discussed in detail. Combining the knowledge generated from these methodologies should aid in rationally designing biocatalyst based on enzymes immobilized in mesoporous materials. 相似文献
Mixed ligand silver(I) complexes of triphenylphosphine and heterocyclic thiones (imidazolidine-2-thione (Imt), diazinane-2-thione (Diaz) and 2-mercaptopyridine (Mpy)) having the general formulae [(Ph3P)Ag(thione)2]NO3 and [(Ph3P)2Ag(thione)]NO3 were prepared and characterized by elemental analysis, IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure of one of the complexes, [Ag(Ph3P)(Diaz)2]2(NO3)2 (1) was determined by X-ray crystallography. The title complex (1) is dinuclear, having each silver atom coordinated to three thione sulfur atoms of Diaz and to one phosphorus atom of PPh3 in a nearly tetrahedral environment, with an average P-Ag-S bond angle of 108.5°. The spectral data of the complexes are consistent with sulfur coordination of the thiones to silver(I). Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentrations and the results showed that the complexes exhibit a wide range of activity against two gram-negative bacteria (E. coli, P. aeruginosa) and molds (A. niger, P. citrinum), while the activities were poor against yeasts (C. albicans, S. cerevisiae). 相似文献
Slow crystallisation at lowered temperature yielded crystals of the “third‐generation” tris(pyrazolyl)borate transfer agent p‐BrC6H4TpCs (Tp′Cs) 1 (triclinic; P$\bar{1}$ ; a = 8.540(4), b = 15.045(6), c = 15.879(7) Å; α = 65.853(8), β = 88.457(8), γ = 75.056(8)°; V = 1791.4(13) Å3; Z = 4). The central caesium ion in 1 interacts with three individual p‐BrC6H4Tp ligands in two different chelating fashions.In particular, κ1‐N‐coordination and η5‐π‐coordination of pyrazole moieties as well as η6‐π‐coordination of the p‐BrC6H4 substituent are observed. Further, comparable coordination of neighbouring caesium ions leads to the formation of polymeric structures connected by two bridging modes. 相似文献
The paramagnetic dinuclear complexes 1,8-bis(cobaltocenyl)naphthalene (2) and 1,8-bis[(pentamethyl-η(5)-cyclopentadienyl)(η(5)-cyclopentadiendiyl)cobalt(II)]naphthalene (4) were synthesized. The molecular structures were characterized by X-ray structure analysis and consisted of two cobaltocenes linked through a distorted naphthalene clamp. Electronic interactions between the two cobalt atoms were observed by cyclic voltammetric studies. Superconducting quantum interference device (SQUID) measurements of the pure compounds and diluted in their diamagnetic iron derivatives, as well as variable-temperature NMR spectroscopy experiments in solution are presented. Magnetic measurements revealed an antiferromagnetic coupling of the electrons in complexes 2 and 4. From NMR spectroscopy experiments, Curie behavior in the temperature range from -60 to +60 °C can be deduced. The electronic structure and magnetic behavior is supported by results of broken-symmetry DFT and multireference calculations along with UV/Vis spectroscopic data, which revealed an intramolecular through space π-π interaction between the cobaltocene units. 相似文献