A Molecular Circuit Regenerator to Implement Iterative Strand Displacement Operations

The predictable chemistry of Watson–Crick base-pairing imparts a unique structural programmability to DNA, enabling the facile design of molecular reactions that perform computations. However, many of the current architectures limit devices to a single operational cycle. Herein, we introduce the design of the “regenerator”, a device based on coupled enthalpic and entropic reactions that permits the regeneration of molecular circuit components.     

An Efficient Straightforward Synthesis of (-)-Bulgecinine

(-)-Bulgecinine 1, a component of the antibiotic bulgecins, was efficiently synthesized from (S)-pyroglutaminol2.