全文获取类型
收费全文 | 3138篇 |
免费 | 492篇 |
国内免费 | 426篇 |
专业分类
化学 | 2292篇 |
晶体学 | 30篇 |
力学 | 225篇 |
综合类 | 45篇 |
数学 | 311篇 |
物理学 | 1153篇 |
出版年
2024年 | 8篇 |
2023年 | 55篇 |
2022年 | 109篇 |
2021年 | 105篇 |
2020年 | 135篇 |
2019年 | 103篇 |
2018年 | 116篇 |
2017年 | 116篇 |
2016年 | 145篇 |
2015年 | 129篇 |
2014年 | 177篇 |
2013年 | 218篇 |
2012年 | 212篇 |
2011年 | 288篇 |
2010年 | 200篇 |
2009年 | 196篇 |
2008年 | 208篇 |
2007年 | 191篇 |
2006年 | 158篇 |
2005年 | 121篇 |
2004年 | 95篇 |
2003年 | 75篇 |
2002年 | 75篇 |
2001年 | 69篇 |
2000年 | 60篇 |
1999年 | 72篇 |
1998年 | 60篇 |
1997年 | 50篇 |
1996年 | 48篇 |
1995年 | 51篇 |
1994年 | 51篇 |
1993年 | 48篇 |
1992年 | 47篇 |
1991年 | 37篇 |
1990年 | 40篇 |
1989年 | 32篇 |
1988年 | 25篇 |
1987年 | 31篇 |
1986年 | 23篇 |
1985年 | 13篇 |
1984年 | 8篇 |
1983年 | 11篇 |
1982年 | 12篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1957年 | 4篇 |
排序方式: 共有4056条查询结果,搜索用时 15 毫秒
91.
信息拓扑指数与烷烃分子热力学性质的关系 总被引:13,自引:0,他引:13
Two topological information indices were constructed based on Randic and Wiener indices, and the values of topological information indices for 85 alkanes were calculated. The thermodynamic properties such as the standard enthalpies of formation, the standard entropies and the standard free energies of formation for these alkanes were also correlated with these topological and information indices. It is found that the thermodynamic properties calculated for both gaseous and liquid states of the 85 alkanes are in excellent agreement with the experimental values through the regression analysis. 相似文献
92.
93.
The 4πs+πs photoadduct from an arene and 1,3-cyclohexadiene may undergo a photochemical rearrangement to the 4πs+πs adduct. 相似文献
94.
Solid-stateSynthesisatLow-heatingTemperatureandCrystalStructureofaDinuclearMolybdenumComplexwithOxalateLigand[Bu_4N]_2[Mo_2O_2(... 相似文献
95.
Ewig CS Berry R Dinur U Hill JR Hwang MJ Li H Liang C Maple J Peng Z Stockfisch TP Thacher TS Yan L Ni X Hagler AT 《Journal of computational chemistry》2001,22(15):1782-1800
A class II valence force field covering a broad range of organic molecules has been derived employing ab initio quantum mechanical "observables." The procedure includes selecting representative molecules and molecular structures, and systematically sampling their energy surfaces as described by energies and energy first and second derivatives with respect to molecular deformations. In this article the procedure for fitting the force field parameters to these energies and energy derivatives is briefly reviewed. The application of the methodology to the derivation of a class II quantum mechanical force field (QMFF) for 32 organic functional groups is then described. A training set of 400 molecules spanning the 32 functional groups was used to parameterize the force field. The molecular families comprising the functional groups and, within each family, the torsional angles used to sample different conformers, are described. The number of stationary points (equilibria and transition states) for these molecules is given for each functional group. This set contains 1324 stationary structures, with 718 minimum energy structures and 606 transition states. The quality of the fit to the quantum data is gauged based on the deviations between the ab initio and force field energies and energy derivatives. The accuracy with which the QMFF reproduces the ab initio molecular bond lengths, bond angles, torsional angles, vibrational frequencies, and conformational energies is then given for each functional group. Consistently good accuracy is found for these computed properties for the various types of molecules. This demonstrates that the methodology is broadly applicable for the derivation of force field parameters across widely differing types of molecular structures. Copyright 2001 John Wiley & Sons, Inc. J Comput Chem 22: 1782-1800, 2001 相似文献
96.
Protein-ligand interactions may lead to the formation of multiple molecular complexes in dynamic exchange, affecting the kinetic and thermodynamic characteristics of the binding equilibrium. We followed the dissociation kinetics of the transient and specific complex of an antithrombotic peptide N-acetyl-Asp(55)-Phe-Glu-Glu-Ile-Pro(60)-Glu-Glu-Tyr-Leu-Gln(65) with human prothrombin by use of (15)N NMR relaxation dispersion spectroscopy of the peptide. Every one of the five (15)N-labeled adjacent residues of the peptide exhibited apparently different kinetic exchange and relaxation behaviors, which were especially evident at different concentrations of prothrombin. Binding-induced (15)N relaxation dispersion of residues Phe(56), Glu(57), Glu(58), and Ile(59) can be fitted phenomenologically to a two-site on-and-off exchange mechanism with physically feasible relaxation and kinetic parameters obtained for residues Phe(56), Glu(58), and Ile(59), independent of the prothrombin concentration. The apparent kinetic parameters of Glu(57) show some dependence on the concentration of prothrombin and the extracted transverse relaxation rate for Glu(57) in the bound state was severalfold higher than that expected for a protein-peptide complex with a size of approximately 72 kDa. In addition, the equilibrium population of the bound peptide obtained for Glu(57) was inconsistent with those for Phe(56), Glu(58), and Ile(59) and with the prothrombin/peptide ratios used in the experiments. These discrepancies can be explained by the presence of two conformations for the peptide-protein complex exchanging at a rate of approximately 100 s(-)(1). In all, our study shows that fast dissociation of protein-peptide complexes can be studied quantitatively using peptide (15)N NMR relaxation dispersion measurements without a precise knowledge of the peptide and protein concentrations. In addition, protein titration was found to improve the accuracy of quantitative analysis and may make it possible to determine the rate of conformational changes within the protein-peptide complex. 相似文献
97.
Xie Yongshu Ni Jia Liu Xueting Liu Qingliang Xu Xiaolong Du Chenxia Zhu Yu 《Transition Metal Chemistry》2003,28(3):367-370
Novel 1:2 and 1:1 (M:L) copper(II) complexes have been prepared from the tridentate ligand 2-(1-methyl-2-aza-5-oxapentyl)phenol (H2L1). The crystal structure of [Cu(HL1)2] (1) exhibits a noncentrosymmetric square-planar geometry with a slightly tetrahedral distortion. The CuII atom is coordinated by two amino N and two phenoxo O atoms of two (HL1)– ligands. The phenoxo and the alkoxy groups are involved in two strong intramolecular hydrogen bonds. The coordination moieties are further connected to a 1D linear structure by the action of intermolecular hydrogen bonds between the alkoxyl and the amino groups. The importance of steric hindrance introduced by the methyl group in the molecular structure and the packing of the complex molecules has been demonstrated. The e.p.r. parameters of (1) have been obtained: g
= 2.231, g
= 2.005, g
iso = 2.080, A
= 185.0 G, A
iso = 86.5 G, A
= (3A
iso – A
)/2 = 37.3 G. These results confirm a distorted square planar stereochemistry with a (
)1 ground state. 相似文献
98.
99.
100.