Synthesis of an asymmetric fullerene dimer via sequential cycloadditions

A single isomer of a monofunctionalised C₇₀ fullerene is isolated and characterised using variable temperature NMR spectroscopy. Pendant methylene bromide groups allow for further cycloaddition reactions and a C₆₀-C₇₀ asymmetric fullerene dimer is thus prepared.     

A six-step synthesis of (S)-5-ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine

The anti-Parkinson’s agent SIB-1508Y was prepared in six steps from (S)-nicotine in 20% overall yield. The strategy involves a regioselective formylation at C-5 of a 1,4-dihydronicotine intermediate.     

Synthesis of oxazolidinedione derived bicalutamide analogs

The synthesis of chiral oxazolidinedione derived bicalutamide analogs has been discussed.     

Trace element concentrations from São Francisco River - PR analyzed with PIXE technique

Summary Kulcsszavak (angolul, ha nem azonos az elozovel)     

Polarization-phase mapping and reconstruction of biological tissue architectonics during diagnosis of pathological lesions

Specific features of the formation of local and statistical polarization structures of laser radiation scattered in phase-inhomogeneous layers (PIL) of biological tissue (BT) were studied. The distribution of azimuth and eccentricity of boundary field polarization was found to correlate with the orientation-phase structure of multifractal PIL. A method of polarization phase reconstruction of BT architectonics was suggested.     

Study of the spectrum of cherenkov light

It is pessible to study experimentally Cherenkov light spectra in a liquid scintillation spectrometer with colour filters. Cherenkov light spectra of⁶⁰Co,¹⁹⁸Au,¹¹⁵Cd,¹⁴³Ce,¹⁴⁰La,³²P,⁸⁶Rb,⁷⁶As,⁴²K and an external standard were studied in a Packard 3375 type liquid scintillation spectrometer, using 11 various Kodak Wratten filters. The absorption maxima of the filters ware in the 410–796 nm interval.     

Properties of (InGa)As/GaAs QW (λ ≈ 1.2 µm) facet-coated edge emitting diode laser

In this paper, we report on the design and optical properties of laser diodes with an emission wave-length of ～1170 nm based on an (InGa)As/GaAs double quantum well active layer. The back and front facet of the laser diodes were coated with SiO_x dielectric films that influence the output optical power by enhancing or lowering the facet reflectivity. The measurements show improvement of the facet-coated laser diode properties in the threshold-current-density reduction along with light output power enhancement. Furthermore, a narrow far field pattern and high side mode suppression have been observed.     

A new approach towards peptidosulfonamides: synthesis of potential inhibitors of bacterial peptidoglycan biosynthesis enzymes MurD and MurE

Peptidosulfonamides are an emerging group of peptidomimetics with a variety of applications in medicinal chemistry. We present a novel approach to the synthesis of peptidosulfonamides, and apply it to a series of new potential inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurE. The synthesis was conducted via N-phthalimido β-aminoethanesulfonyl chlorides, which are new building blocks for the synthesis of peptidosulfonamides. In the most crucial step, sulfonic acids or their sodium salts were converted into the corresponding sulfonyl chlorides using an excess of either SOCl₂ or SOCl₂/DMF, and then coupled to the C-protected amino acid. None of the compounds significantly inhibited MurD, however, some inhibited MurE; one had an IC₅₀ below 200 μM, which constitutes a promising starting point for further development. Molecular modelling simulations were performed on two analogues to investigate the absence of inhibitory activity of the sulfonamide compounds on MurD.