Coupling resonance of floating slab and supporting concrete box structure

This paper mainly investigates the effect of coupling resonance of floating slab and supporting short concrete box. The similarities and differences in vibration behaviors between long (30 m) and short (1.5 m) lengths of concrete box structures with the same cross-section were analyzed with finite element model (FEM). The results suggest that the major local modes for vibration and structure-borne sound radiation for long and short box structures are the same. A short concrete hollow box was constructed to verify the theoretical vibration results, and six combinations of floating slabs were installed on the box to identify the vibration and structure-borne sound control by experimental method. The resonance modes due to either concrete box or floating slab should degrade the vibration isolation performance of the floating system. There may be strong coupling between roll mode (rigid body rotation mode in the y-z plane) of the floating slab and local distortion mode of the short box structure and this can change the vibration resonance frequencies and amplify the vibration.     

Distinguishing between the interior pressures induced from two independent sources within a room using the probabilistic approach

In this paper, a probabilistic approach is introduced and used to distinguish between the interior pressures that are induced from two independent sound sources within a rectangular room. One source is a vibrating wall of the room and the other is an interior point source. The model is set up using the modal analysis method. In the probabilistic method, the probability densities of the uncertain acoustic model parameters are computed. The values of highest probability density are identified and assigned to the uncertain parameters in the acoustic model. The contributions of the sound sources to the total pressure are then obtained from the acoustic model input with the identified parameters. The effects of the modal truncations, the modeling errors, and the measurement locations on the accuracies of the identification process are studied.     

The Automorphism Group of a Simple Tracially AI Algebra

The structure of the automorphism group of a simple TAI algebra is studied. In particular, we show that is isomorphic (as a topological group) to an inverse limit of discrete abelian groups for a unital, simple, AH algebra with bounded dimension growth. Consequently, is totally disconnected. Another consequence of our results is the following: Suppose A is the transformation group C*-algebra of a minimal Furstenberg transformation with a unique invariant probability measure. Then the automorphism group of A is an extension of a simple topological group by the discrete group .     

Characterizing the structure of preserved information in quantum processes

We introduce a general operational characterization of information-preserving structures-encompassing noiseless subsystems, decoherence-free subspaces, pointer bases, and error-correcting codes-by demonstrating that they are isometric to fixed points of unital quantum processes. Using this, we show that every information-preserving structure is a matrix algebra. We further establish a structure theorem for the fixed states and observables of an arbitrary process, which unifies the Schr?dinger and Heisenberg pictures, places restrictions on physically allowed kinds of information, and provides an efficient algorithm for finding all noiseless and unitarily noiseless subsystems of the process.     

Central neurocytoma: typical magnetic resonance spectroscopy findings and atypical ventricular dissemination

PURPOSE: Central neurocytomas (CNCs) are rare neuronal tumors that have a favorable prognosis and lower rate of recurrence compared with other intraventricular neoplasms. Although it may be difficult to distinguish CNC on conventional neuroimaging, typical MR spectroscopy (MRS) features have been reported. We describe the MRI and MRS features of CNC. MATERIALS AND METHODS: Eight patients with CNC were reviewed. Three patients underwent presurgical in vivo single-voxel MRS at short echo time (TE, 35 ms) and multi-voxel MR spectroscopic imaging at long TE (144 ms). The surgically resected tumor specimen of one of these patients was also studied ex vivo using high-resolution magic angle spinning (HRMAS) nuclear magnetic resonance. RESULTS: All eight tumors were located in the lateral ventricles. In six patients, CNC extended into the third ventricle, and in two patients the tumor showed further contiguous intraventricular dissemination into the fourth ventricle. In all three patients who underwent MRS, a characteristic metabolite peak was detected at 3.55 parts per million (ppm) at both long and short TE. HRMAS confirmed the presence of elevated glycine (Gly) at 3.55 ppm, without increase in the concentration of myo-inositol found at the same chemical shift. Elevated choline (at 3.2 ppm) was also seen in all three patients. CONCLUSION: On MRS, CNCs have a typical appearance with a metabolite peak at 3.55 ppm due to increased Gly, and this feature may be helpful in presurgical diagnosis. Although they are rare benign intraventricular tumors, in atypical cases, CNCs can show extensive intraventricular dissemination into the fourth ventricle.     

A Disulfide Intercalator Toolbox for the Site‐Directed Modification of Polypeptides

A disulfide intercalator toolbox was developed for site‐specific attachment of a broad variety of functional groups to proteins or peptides under mild, physiological conditions. The peptide hormone somatostatin (SST) served as model compound for intercalation into the available disulfide functionalization schemes starting from the intercalator or the reactive SST precursor before or after bioconjugation. A tetrazole–SST derivative was obtained that undergoes photoinduced cycloaddition in mammalian cells, which was monitored by live‐cell imaging.     

Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis,Non-Acylating Performance and In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.     

Functionalization of Polyethyleneimine with Hollow Cyclotriveratrylene and Its Subsequent Supramolecular Interaction with Doxorubicin

In this paper, a modified Cyclotriveratrylene was synthesized and linked to a branched Polyethylenimine, and this unique polymeric material was subsequently examined as a potential supramolecular carrier for Doxorubicin. Spectroscopic analysis in different solvents had shown that Doxorubicin was coordinated within the hollow-shaped unit of the armed Cyclotriveratrylene, and the nature of the host–guest complex revealed intrinsic Van der Waals interactions and hydrogen bonding between the host and guest. The strongest interaction was detected in water because of the hydrophobic effect shared between the aromatic groups of the Doxorubicin and Cyclotriveratrylene unit. Density functional theory calculations had also confirmed that in the most stable coordination of Doxorubicin with the cross-linked polymer, the aromatic rings of the Doxorubicin were localized toward the Cyclotriveratrylene core, while its aliphatic chains aligned closer with amino groups, thus forming a compact supramolecular assembly that may confer a shielding effect on Doxorubicin. These observations had emphasized the importance of supramolecular considerations when designing a novel drug delivery platform.