Characterization of supercooling suppression of microencapsulated phase change material by using DSC

Supercooling suppression of microencapsulated n-tetradecane was measured using differential scanning calorimetry. Results indicate that the degree of supercooling is positively affected by the amount and type of nucleating agent present in bulk and microencapsulated n-tetradecane which it is used as a phase change material (MPCM). Results also demonstrate that the melting point of the n-tetradecane is fairly independent of nucleating agent concentration (0 – 4%). Conversely, the latent heat of fusion of n-tetradecane decreases considerably with nucleating agent amount and the initiation of crystallization point is inversely proportional to cooling rate.     

Theory of oscillation type viscometers III: A thin disk

The small amplitude oscillation of a thin disk of finite radius suspended in an infinite fluid is considered with a view toward its use as a viscometer. The fluid motion is analyzed under the assumption that the boundary layer thickness of the fluid is small compared with the radius of the disk but large compared with the thickness of the disk. Formulas are obtained relating the frequency and decrement of oscillation to the density and viscosity of the fluid.

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Zusammenfassung Es wird untersucht, inwieweit eine dünne aufgehängte Scheibe endlicher Abmessung, wenn sie mit kleiner Amplitude schwingt, sich zur Messung der Zähigkeit verwenden lässt. Die Bewegung der Flüssigkeit wird unter der Voraussetzung analysiert, dass die Grenzschichtdicke klein ist im Vergleich zum Radius der Scheibe, aber gross verglichen mit der Scheibendicke. Die Formeln zeigen die Abhängigkeit der Frequenz und des logarithmischen Dekrements der Schwingung von der Dichte und der Zähigkeit der Flüssigkeit.

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This research was supported by the United States Air Force through the Air Force Office of Scientific Research of the Air Research and Development Command, under contract No. AF 18 (600) 1548. Reproduction in whole or in part is permitted for any purpose of the United States Government. Part of the work was done while one of the authors (G. F. N.) was being supported by a grant from the Alfred P. Sloan Foundation.     

Aqueous phosphoric acid as a mild reagent for deprotection of the t-butoxycarbonyl group

Aqueous phosphoric acid (85 wt%) is an efficient and mild reagent for the deprotection of N-BOC groups. Acid sensitive functionalities including benzyl and methyl esters, TBDMS ether, CBZ and isopropylidene groups are compatible with the reaction conditions. The reactions are high yielding, and the workup is convenient.     

Theory of oscillation type viscometers V: Disk oscillating between fixed plates

A disk oscillating between two fixed plates is considered as an instrument for absolute measurements of viscosity. The existing theories relating the viscosity to the decrement of oscillation are improved by calculating the effects of the edge. This is done by assuming that the separation between the plates is small compared with both the radius of the disk and the boundary layer thickness. A comparison is made with the experimental data ofKestin andPilarczyk for which the present theory is estimated to be correct to 0·1%.

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Zusammenfassung Es wird untersucht, ob eine zwischen zwei feststehenden Platten schwingende Scheibe als Gerät für die Absolutmessung der Zähigkeit von Flüssigkeiten benutzt werden kann. Die dafür bestehenden Theorien, bei denen die Viskosität aus dem logarithmischen Dekrement der Schwingung berechnet wird, sind hier durch die Berücksichtigung der Randeffekte erweitert worden, unter der Voraussetzung, dass der Abstand zwischen den beiden feststehenden Platten klein ist im Verhältnis zum Radius der Scheibe und zur Grenzschichtdicke. Die Theorie stimmt mit den vonKestin undPilarczyk experimentell gefundenen Werten auf 0,1% genau überein.

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This research was supported by the United States Air Force through the Air Force Office of Scientific Research of the Air Research and Development Command, under contract No. AF 18 (600) 1548. Reproduction in whole or in part is permitted for any purpose of the United States Govermnent. Part of the work was done while the author was being supported by a grant from the Alfred P. Sloan Foundation.     

Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination

beta-Piperidinoethylsulfides are oxidized by m-chloroperbenzoic acid to intermediates containing both N-oxide and sulfone functions. These undergo a Cope-type elimination to a vinylsulfone that can be captured by amines to afford beta-aminoethylsulfones. When a beta-aminoethylsulfone group is linked to the 4-position of a phenyl group attached at N-2 of O6-cyclohexylmethylguanine, the resulting derivatives are inhibitors of the cyclin-dependent kinase CDK2. One of the most potent inhibitors (IC50 = 45 nM) contained a N-3-hydroxypropyl group on the aminoethylsulfonyl substituent. The crystal structure of this inhibitor bound to CDK2/cyclin A was determined and shows an unusual network of hydrogen bonds. The synthetic methodology developed can be utilized in multiple-parallel format and has numerous potential applications in medicinal chemistry.     

A possible role for MRI in polyarteritis nodosa: The “creeping fat” sign

We describe a case of polyarteritis nodosa with diffuse abnormalities in subcutaneous fat by magnetic resonance imaging. These abnormalities returned to normal following treatment. Magnetic resonance imaging may have a role in the identification and diagnosis of systemic vasculitis.     

Dynamic Scattering and Material Flow in a Nematic Liquid Crystal

Results are presented which show how defects in a nematic liquid crystal can be used to investigate material flow when external electric fields are applied. These results include measurements of the size of flow cells, which were created between the electrodes by an electric field. The electrodes, which were made of transparent conductive coated glass, were placed in a vertical position so that flow cells could be observed from the top while dynamic scattering was observed when viewing normal to the electrodes.