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排序方式: 共有336条查询结果,搜索用时 31 毫秒
51.
Sophia Boden Franziska Reise Jessica Kania Thisbe K. Lindhorst Laura Hartmann 《Macromolecular bioscience》2019,19(4)
This study investigates the influence of an increasingly hydrophobic backbone of multivalent glycomimetics based on sequence‐defined oligo(amidoamines) on their resulting affinity toward bacterial lectins. Glycomacromolecules are obtained by stepwise assembly of tailor‐made building blocks on solid support, using both hydrophobic aliphatic and aromatic building blocks to enable a gradual change in hydrophobicity of the backbone. Their binding behavior toward model lectin Concanavalin A (ConA) is evaluated using isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) showing higher affinities for glycomacromolecules with higher content of hydrophobic and aromatic moieties in the backbone. Finally, glycomacromolecules are tested in a bacterial adhesion inhibition study against Escherichia coli where more hydrophobic backbones yield higher inhibitory potentials most likely due to additional secondary interactions with hydrophobic regions of the protein receptor as well as a change in conformation exposing carbohydrate ligands for increased binding. Overall, the results highlight the influence and thereby importance of the polymer backbone itself on the resulting properties of polymeric biomimetics. 相似文献
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G. Daikuhara E. Truog L. Michaelis L. T. Sharp D. R. Hoogland H. A. Noyes O. Arrhenius C. B. Lipman H. R. Christensen F. W. Parker H. Kappen A. Densch A. Rippel Th. Arnd O. Schreiner G. Loges E. Ramann F. K. Cameron R. Ulbricht W. Wolf W. Jani Biéler-Chatelan E. A. Mitscherlich C. W. Davis B. S. Davisson H. Neubauer W. Schneider Fr. Czapek G. Wunder J. K. Greisenegger K. Vorbuchner H. Niklas Hirschberger Ausschuss für Boden und Düngung des Verbandes Landwirtschaftlicher Versuchs-Stationen im Deutschen Reiche 《Analytical and bioanalytical chemistry》1924,65(6-7):273-274
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Dr. Samuel C. Scott Dr. Jamie A. Cadge Grace K. Boden Prof. John F. Bower Dr. Christopher A. Russell 《Angewandte Chemie (International ed. in English)》2023,62(23):e202301526
We describe a AuI complex of a hemi-labile (C^N) N-heterocyclic carbene ligand that is able to mediate oxidative addition of aryl iodides. Detailed computational and experimental investigations have been undertaken to verify and rationalize the oxidative addition process. Application of this initiation mode has resulted in the first examples of “exogenous oxidant-free” AuI/AuIII catalyzed 1,2-oxyarylations of ethylene and propylene. These demanding yet powerful processes establish these commodity chemicals as nucleophilic-electrophilic building blocks in catalytic reaction design. 相似文献
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Neville Murphy Dr. William J. Tipping Henry J. Braddick Dr. Liam T. Wilson Prof. Nicholas C. O. Tomkinson Prof. Karen Faulds Prof. Duncan Graham Dr. Pau Farràs 《Angewandte Chemie (International ed. in English)》2023,62(48):e202311530
Multiplex optical detection in live cells is challenging due to overlapping signals and poor signal-to-noise associated with some chemical reporters. To address this, the application of spectral phasor analysis to stimulated Raman scattering (SRS) microscopy for unmixing three bioorthogonal Raman probes within cells is reported. Triplex detection of a metallacarborane using the B−H stretch at 2480–2650 cm−1, together with a bis-alkyne and deuterated fatty acid can be achieved within the cell-silent region of the Raman spectrum. When coupled to imaging in the high-wavenumber region of the cellular Raman spectrum, nine discrete regions of interest can be spectrally unmixed from the hyperspectral SRS dataset, demonstrating a new capability in the toolkit of multiplexed Raman imaging of live cells. 相似文献
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Neville SM Leita BA Halder GJ Kepert CJ Moubaraki B Létard JF Murray KS 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(32):10123-10133
Three analogous one dimensional (1D) polymeric iron(II) spin crossover (SCO) materials containing the new ligand 4,6-bis(2',2'-pyridyl)pyrazine (bdpp) have been comprehensively characterised magnetically (thermal and light-induced) and structurally. Within this series are two polymorphs of the formula [Fe(NCS)(2)(bdpp)], 1 and 2 a, which differ magnetically in that phase 1 undergoes a full two-step SCO (T(1/2(1))=135 K and T(1/2(2))=90 K) whereas phase 2 a remains high spin (HS) over all temperatures. The central distinction between these two materials lies in the presence of intermolecular pi-pi interactions generated by the crystal packing in 1, which are absent in 2 a. The isostructural selenocyanate analogue of 2 a, [Fe(NCSe)(2)(bdpp)], 2 b, undergoes a full two-step SCO (T(1/2(1))=200 K and T(1/2(2))=125 K). Structural analyses of 1 and 2 b at a range of temperatures provide deep insight into their two-step SCO nature. Structural analysis of 1 at 25 K (1(LS-LS)), 123 K (1(LS-HS)) and 250 K (1(HS-HS)) reveals two distinct iron(II) centres at each temperature, with ordered, alternating HS and LS (low spin) sites at the intermediate plateau (IP) temperatures. In contrast, structural analysis of 2 b at 90 K (2 b(LS)), 150 K (2 b(LS/HS)) and 250 K (2 b(HS)) reveals one unique iron(II) centre at each temperature with an "averaged" LS/HS character at the IP temperature. Weak planes of diffuse scattering in the single-crystal X-ray diffraction patterns were observed for this phase at 90 and 150 K, indicating that 1D long range ordering of alternating HS/LS iron(II) centres occurs along the 1D coordination chains, but that there is no correlation between chains. The lack of observable diffuse scattering at 250 K suggests that the onset of the 1D structural ordering in the chain direction corresponds to the first step of the SCO and that this structural transition is electronically driven. The photomagnetic properties of both 1 and 2 b have been investigated and show approximately 62 and 53 % photo-excitation of a HS metastable state at low temperatures and T(LIESST) values of 55 and 49 K, respectively. Relaxation studies on the HS fraction in 2 b fitted well to a stretched exponential model with kinetic parameters indicative of weak cooperativity. 相似文献
59.
S P Bacon L N Boden J Lee J L Repovsch 《The Journal of the Acoustical Society of America》1999,106(1):341-350
Growth-of-masking (GOM) functions were obtained in three groups of normal-hearing subjects using a simultaneous-masking paradigm. In all cases, the signal frequency (fs) was higher than the masker frequency (fm), either by a certain ratio (1.44) or by a certain distance [3 equivalent rectangular bandwidths (ERBs)]. The purpose was to evaluate the effect of overall frequency on the slope of the steep portion of the GOM function, and to evaluate the change in slope that can occur at high levels. Signal frequency ranged from 400 to 5000 Hz, and masker level ranged from 40 to 95 dB SPL. On average, the slope of the steep portion of the GOM function was about 1.4 for signal frequencies from 400 to 750 Hz, and 2.0 for signal frequencies from 1944 to 5000 Hz. This is consistent with the possibility that the cochlea may behave more linearly at the apical (low-frequency) region than at the basal (high-frequency) region. In addition, for signal frequencies at and above 750 Hz, the slope of the masking function changed from a value much greater than 1.0 to a value of 1.0 at high levels. The change in slope was better correlated with signal sensation level (i.e., amount of masking) than with either signal or masker SPL: the lack of a change at the lower signal frequencies may reflect the smaller amounts of masking there. The change to a linear growth of masking may represent a change in the response to the signal from compressive to linear at high levels. 相似文献
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