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11.
Sara Busi Jarmo Ropponen Jussi Valkonen Kari Rissanen 《Journal of solid state chemistry》2004,177(10):3757-3767
Series of new aromatic R2R′2N+Br− (R=benzyl, 4-methylbenzyl, 2-phenylethyl, 3-phenylpropyl; R′=ethyl, methyl, isopropyl) or RR′2NH+Br−-type (R=benzyl, R′=isopropyl) quaternary ammonium bromides were prepared by using novel synthetic route in which a formamide (N,N-diethylformamide, N,N-dimethylformamide, N,N-diisopropylformamide) is treated with aralkyl halide in presence of a weak base. The compounds were characterized by 1H-NMR and 13C-NMR spectroscopy and mass spectrometry. Structures of the crystalline compounds were determined by X-ray single crystal diffraction, and in addition the powder diffraction method was used to study the structural similarities between the single crystal and microcrystalline bulk material. Three of the compounds crystallized in monoclinic, two in orthorhombic and one in triclinic crystal system, showing ion pairs, which are interconnected by weak hydrogen bonds and weak π-π interactions between the phenyl rings. Three of the compounds appeared as viscous oil or waxes. Finally, TG/DTA and DSC methods were used to analyze thermal properties of the prepared compounds. The lowest melting points were obtained for diethyldi-(2-phenylethyl)ammonium bromide (122.2 °C) and for diethyldi-(3-phenylpropyl)-ammonium bromide (109.1 °C). In general, decomposition of the compounds started at 170-190 °C without identifiable cleavages, thus liquid ranges of 30-70 °C were observed for some of the compounds. 相似文献
12.
The relative thermodynamic stabilities of 24 pairs of carbon-carbon double-bondexo-endo isomeric 2-substituted 4-methylene-1,3-dioxolanes (a) and 4-methyl-1,3-dioxoles (b) have been determined by base-catalyzed chemical equilibration in DMSO solution. In all cases, theendo isomer (b) is the favored species at thermodynamic equilibrium. A single alkyl substitutent on C-2 gives only a negligible contribution to the relative stability of the isomeric forms, but the presence of two alkyl groups on C-2 increases the relative stability of theendo isomer by 2–3 kL mol–1. A still higher effect in favor of theendo isomer is produced by introduction of a single alkoxy group on C-2; this effect is further slightly accentuated by 2,2-dialkoxy substitution at C-2. The origin of the favorable effect of 2-alkoxy substitution on the relative stability of theendo isomer is not clear, but it seems to arise from an unexpected stability of theendo isomer rather than from an enhanced destabilization of theexo form. 相似文献
13.
Tommi Kaplas Kari Laitinen Tuula Moilanen Yrj? Tolonen Kristoffer Albrecht Raimo Silvennoinen 《Optical Review》2010,17(3):252-256
Traditional Japanese woodblock printing is a centuries old art form. This time-honoured form of art is at risk of extinction
as a consequence of the increasing lack of availability of wild cherry trees, which are a traditionally used woodblock material.
Solutions for this material problem have been investigated for several years, but none of the tested materials has been sufficient
when compared with the watercolour print quality imprinted by wild cherry woodblocks. To contribute to overcoming this material
problem, we have investigated the physical properties of heat-treated woodblock materials made from different wood species.
The International Commission on Illumination (CIE) tristimulus values, the CIELAB coordinates, the total reflectance, and
the gloss, as well as, the water contact angle from the woodblock surface is observed to have a strong relation to the surface
treatment of a woodblock. The surface treatment of a woodblock, in turn, relates to its water delivery, which is the basis
for watercolour printing. 相似文献
14.
15.
Riikka T. Kuosmanen Dr. Khai-Nghi Truong Prof. Dr. Kari T. Rissanen Dr. Elina I. Sievänen 《ChemistryOpen》2021,10(11):1150-1157
Six bile acid alkyl amide derivatives were studied with respect to their gelation properties. The derivatives were composed of three different bile acids with hexyl or cyclohexyl side chains. The gelation behaviour of all six compounds were studied for 36 solvents with varying polarities. Gelation was observed mainly in aromatic solvents, which is characteristic for bile-acid-based low molecular weight gelators. Out of 108 bile acid-solvent combinations, a total of 44 gel systems were formed, 28 of which from lithocholic acid derivatives, only two from deoxycholic acid derivatives, and 14 from cholic acid derivatives. The majority of the gel systems were formed from bile acids with hexyl side chains, contrary to the cyclohexyl group, which seems to be a poor gelation moiety. These results indicate that the spatial demand of the side chain is the key feature for the gelation properties of the bile acid amides. 相似文献
16.
Kari Gabrielse Amit Gangar Dr. Nigam Kumar Dr. Jae Chul Lee Dr. Adrian Fegan Jing Jing Shen Dr. Qing Li Dr. Daniel Vallera Dr. Carston R. Wagner 《Angewandte Chemie (International ed. in English)》2014,53(20):5112-5116
The ability to engineer and re‐program the surfaces of cells would provide an enabling synthetic biological method for the design of cell‐ and tissue‐based therapies. A new cell surface‐engineering strategy is described that uses lipid‐chemically self‐assembled nanorings (lipid‐CSANs) that can be used for the stable and reversible modification of any cell surface with a molecular reporter or targeting ligand. In the presence of a non‐toxic FDA‐approved drug, the nanorings were quickly disassembled and the cell–cell interactions reversed. Similar to T‐cells genetically engineered to express chimeric antigen receptors (CARS), when activated peripheral blood mononuclear cells (PBMCs) were functionalized with the anti‐EpCAM‐lipid‐CSANs, they were shown to selectively kill antigen‐positive cancer cells. Taken together, these results demonstrate that lipid‐CSANs have the potential to be a rapid, stable, and general method for the reversible engineering of cell surfaces and cell–cell interactions. 相似文献
17.
18.
Fast gas chromatography/negative-ion chemical ionization mass spectrometric (GC/NICI-MS) assay combined with rapid and nonlaborious sample preparation is presented for the simultaneous determination of benzodiazepines and alpha-hydroxy metabolites, zaleplon and zopiclone in whole blood. The compounds were extracted from 100 microl of whole blood by simultaneous multitube, microscale liquid-liquid extraction (LLE) and derivatized by N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), without the need for the time-consuming concentration stage. In the analytical separation, various parameters of fast GC/NICI-MS were applied, e.g. the use of hydrogen as a GC carrier gas, a high carrier gas velocity, a small film thickness of the analytical column, fast MS data acquisition, fast temperature ramping, and high initial and final temperatures of GC column. Sensitive identification, screening and quantitation of 18 compounds of interest were achieved in chromatographic separation in only 4.40 min. Accurate and reproducible results were obtained by using five different and carefully selected deuterated analogues on the basis of the chemical properties of the target analytes. Nevertheless, for alpha-OH-midazolam, and for bromazepam and flunitrazepam at low concentrations, the results can be considered only semiquantitative on the basis of the validation data. The extraction efficiencies ranged from 74.3 to 105.7% and the limits of quantitation (LOQ) from 1 to 100 ng ml(-1). Rapid sample preparation and fast chromatographic separation allowed cost-efficient, reliable and high sample-throughput analyses with a low amount of manual work. The method was fully validated and accredited according to EN ISO/IEC 17025 standards and is applicable for sensitive, reliable and quantitative determination of benzodiazepines, zaleplon and zopiclone, e.g. in clinical and forensic toxicology. 相似文献
19.
Amir Averbuch Valery Zheludev Pekka Neittaanmäki Pekka Wartiainen Kari Huoman Kim Janson 《Applied Acoustics》2011,(1):22-34
We present a robust algorithm to detect the arrival of a boat of a certain type when other background noises are present. It is done via the analysis of its acoustic signature against an existing database of recorded and processed acoustic signals. We characterize the signals by the distribution of their energies among blocks of wavelet packet coefficients. To derive the acoustic signature of the boat of interest, we use the Best Discriminant Basis method. The decision is made by combining the answers from the Linear Discriminant Analysis (LDA) classifier and from the Classification and Regression Trees (CART) that is also accompanied with an additional unit, called Aisles, that reduces false alarms rate. The proposed algorithm is a generic solution for process control that is based on a learning phase (training) followed by an automatic real time detection while minimizing the false alarms rate. 相似文献
20.
Ariadna Lázaro Cristina Balcells Dr. Josefina Quirante Prof. Josefa Badia Prof. Laura Baldomà Dr. Jas S. Ward Prof. Kari Rissanen Dr. Mercè Font-Bardia Prof. Laura Rodríguez Dr. Margarita Crespo Prof. Marta Cascante 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(9):1947-1952
Platinum-based chemotherapy persists to be the only effective therapeutic option against a wide variety of tumours. Nevertheless, the acquisition of platinum resistance is utterly common, ultimately cornering conventional platinum drugs to only palliative in many patients. Thus, encountering alternatives that are both effective and non-cross-resistant is urgent. In this work, we report the synthesis, reduction studies, and luminescent properties of a series of cyclometallated (C,N,N′)PtIV compounds derived from amine–imine ligands, and their remarkable efficacy at the high nanomolar range and complete lack of cross-resistance, as an intrinsic property of the platinacycle, against multiplatinum-resistant colorectal cancer (CRC) and castration-resistant prostate cancer (CRPC) metastatic cell lines generated for this work. We have also determined that the compounds are effective and selective for a broader cancer panel, including breast and lung cancer. Additionally, selected compounds have been further evaluated, finding a shift in their antiproliferative mechanism towards more cytotoxic and less cytostatic than cisplatin against cancer cells, being also able to oxidize cysteine residues and inhibit topoisomerase II, thereby holding great promise as future improved alternatives to conventional platinum drugs. 相似文献