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11.
Nedialkov PT Zheleva-Dimitrova D Girreser U Kitanov GM 《Natural product research》2007,21(12):1056-1060
A new isocoumarin, annulatomarin (1), together with the known physcion and beta-sitosterol were isolated from the aerial parts of Hypericum annulatum. The structure of the new compound was established as 6,8-dihydroxy-7-methoxy-3-phenyl-3,4-dihydro-1H-isochromen-1-one on the basis of detailed spectroscopic analysis. Annulatomarin exhibited a modest growth-inhibitory activity in vitro against human chronic myeloid leukaemia LAMA-84 cells with an IC(50) = 111 microM. 相似文献
12.
Milena P. Popova Boryana S. Trusheva Paraskev T. Nedialkov Iva Tsvetkova Dolly P. Pardo-Mora Hristo Najdenski 《Natural product research》2020,34(19):2779-2786
AbstractTwo new δ-tocotrienol derivatives with oxidized terminal chain: 5,6-dioxo-garcinoic acid (trans-13′-carboxy-5,6-dioxo-δ-tocotrienol) (2) and 5-hydroxy-8b-oxo garcinoic acid (trans-13′-carboxy-5-hydroxy-8b-oxo-δ-tocotrienol) (3), together with one known derivative garcinoic acid (trans-13′-carboxy-δ-tocotrienol) (1) were isolated from a Colombian propolis. Garcinoic acid was found as a propolis constituent for the first time. The isolated compounds and crude ethanolic extract demonstrated high antimicrobial activity against Staphylococcus aureus and Candida albicans (MICs range: 10–39?μg/ml) as well as promising antioxidant potential in DPPH assay. Compound 3 displayed highest radical scavenging activity, even higher than that of dl-α-tocopherol, used as a positive control. 相似文献
13.
Zheleva-Dimitrova D Nedialkov P Girreser U Kitanov G 《Natural product research》2012,26(17):1576-1583
The occurrence of three known benzophenones, namely annulatophenonoside, acetylannulatophenonoside and annulatophenone as well as a flavonol O-glycoside guajaverin in the aerial parts of Hypericum maculatum Crantz was established. In addition, hyperoside, isoquercitrin and miquelianin were isolated from this plant, as well. Radical scavenging and antioxidant activities of the isolated compounds were examined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) free radicals, ferric reducing antioxidant power (FRAP) assay and inhibition of lipid peroxidation in linoleic acid system by the ferric thiocyanate method. Isoquercitrin demonstrates the highest DPPH radical scavenging (96.6?±?0.3%), FRAP (23.8?±?0.2 Trolox equivalent, TE?mol?1) and antioxidant activity in linoleic acid system. Guajaverin and acetylannulatophenonoside show significantly strong ABTS radical scavenging activity (93.9?±?0.4% and 93.4?±?0.6%, respectively), which is comparable to that of ascorbic acid (96.2?±?0.4%). 相似文献
14.
We investigate solution techniques for numerical constraint-satisfaction problems and validated numerical set integration methods for computing reachable sets of nonlinear hybrid dynamical systems in the presence of uncertainty. To use interval simulation tools with higher-dimensional hybrid systems, while assuming large domains for either initial continuous state or model parameter vectors, we need to solve the problem of flow/sets intersection in an effective and reliable way. The main idea developed in this paper is first to derive an analytical expression for the boundaries of continuous flows, using interval Taylor methods and techniques for controlling the wrapping effect. Then, the event detection and localization problems underlying flow/sets intersection are expressed as numerical constraint-satisfaction problems, which are solved using global search methods based on branch-and-prune algorithms, interval analysis and consistency techniques. The method is illustrated with hybrid systems with uncertain nonlinear continuous dynamics and nonlinear invariants and guards. 相似文献