A simple one-pot procedure for the direct conversion of alcohols into alkyl nitriles using TsIm

A convenient and efficient one-pot preparation of nitriles from alcohols using N-(p-toluenesulfonyl)imidazole (TsIm) is described. In this method, treatment of alcohols with a mixture of NaCN, TsIm and triethylamine in the presence of catalytic amounts of tetra-n-butylammonium iodide (TBAI) in refluxing DMF furnishes the corresponding alkyl nitriles in good yields. This methodology is highly efficient for various structurally diverse alcohols with selectivity for ROH: 1° > 2° > 3°.     

Mild and convenient one pot synthesis of Schiff bases in the presence of P2O5/Al2O3 as new catalyst under solvent-free conditions

In this study P₂O₅/Al₂O₃ is found to catalyze the preparation of Schiff bases from the reaction of carbonyl compounds with primary amines efficiently under solvent-free conditions. The advantages of this friendly, environmentally and mild method are such as simplicity of the reaction procedure, the elimination of solvents, simple work-up, high product yields and short reaction times.     

Preparation of DSA@MNPs and application as heterogeneous and recyclable nanocatalyst for oxidation of sulfides and oxidative coupling of thiols

Research on Chemical Intermediates - Dopamine sulfamic acid-functionalized magnetic Fe3O4 nanoparticles (DSA@MNPs) were prepared by a very simple and inexpensive procedure using commercial...     

An enantioselective chiral Brønsted acid catalyzed imino-azaenamine reaction

The enantioselective Br?nsted acid catalyzed addition of methyleneaminopyrrolidine to N-Boc imines has been achieved in the presence of chiral phosphoric acids derived from 3,3'-di(phenanthryl)-H8-BINOL. The corresponding aminohydrazones have been isolated in good yields with enantiomeric excesses up to 90%. [reaction: see text]     

Synthesis of Acyclic Nucleosides with N‐[(Benzyloxy)(aryl)methyl] Substituents as Potential HEPT,EBPU, and TNK‐651 Analogues

The syntheses of the novel acyclic nucleosides 5a – 5m , carrying different N‐[(benzyloxy)(aryl)methyl] substituents, are described (Scheme). These compounds could be prepared in medium‐to‐good yields by either direct or silyl‐assisted coupling of the electrophiles 6 with either purine or pyrimidine nucleobases, or with different imidazole derivatives. The reactivity of the positively charged electrophilic intermediates derived from 6 upon Cl^? abstraction was rationalized by ab initio HF/6‐311G quantum‐mechanic calculations. The positive charge was found to be dispersed differently, depending on the electronic properties of the aryl substituents.     

Toughness amplification in natural composites

Natural structural materials such as bone and seashells are made of relatively weak building blocks, yet they exhibit remarkable combinations of stiffness, strength and toughness. This performance can be largely explained by their “staggered microstructure”: stiff inclusions of high aspect ratio are laid parallel to each other with some overlap, and bonded by a softer matrix. While stiffness and strength are now well understood for staggered composites, the mechanisms involved in fracture are still largely unknown. This is a significant lack since the amplification of toughness with respect to their components is by far the most impressive feature in natural staggered composites such as nacre or bone. Here a model capturing the salient mechanisms involved in the cracking of a staggered structure is presented. We show that the pullout of inclusions and large process zones lead to tremendous toughness by far exceeding that of individual components. The model also suggests that a material like nacre cannot reach steady state cracking, with the implication that the toughness increases indefinitely with crack advance. These findings agree well with existing fracture data, and for the first time relate microstructural parameters with overall toughness. These insights will prove useful in the design of biomimetic materials, and provide clues on how bone fractures at the nano and microscales.     

Charge transfer and bipolar charging of particles in a bubbling fluidized bed

Particle-particle and particle-wall collisions in gas-solid fluidized beds lead to charge accumulation on particles.This work evaluated the effect of fluidization time on charge transfer and bipolar charging(charge separation)and their influence on hydrodynamic structures in a fluidized bed.Experiments were performed with glass beads and polyethylene particles in a glass column.The pressure fluctuations and net electrostatic charge of particles were measured during fluidization.Wavelet and short-time Fourier transforms were used to analyze pressure fluctuations.The results revealed that bipolar charging is the dominant tribocharging mechanism in a bed of glass beads.Bipolar charging in a bed of particles with a narrow size distribution does not affect either hydrodynamic structures or the transition velocity to the turbulent regime.A large difference between the work functions of the wall and particle in the bed of polyethylene particles leads to high charge transfer.Formation of a stagnant particle layer on the wall eventually causes the energy of macro-structures to increase to its maximum.At longer fluidization times,the macro-structural energy decreases and bubbles shrink until the electrostatic charge reaches the equilibrium level.These results well describe the effect of fluidization time on hydrodynamic structures.     

Back propagation modeling of shear stress and viscosity of aqueous Ionic-MXene nanofluids

Journal of Thermal Analysis and Calorimetry - Back-propagation modeling of viscosity and shear stress of Ionic-MXene nanofluid is carried out in this work. The data for Ionic-MXene nanofluid of...