Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design,synthesis, in vivo,and in silico evaluations

Molecular Diversity - A novel series of 1,2,3-triazolo-benzodiazepine derivatives 6a–o has been synthesized and evaluated in vivo for their anticonvulsant activities using by...     

Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications

Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester‐based materials show excellent compatibility with blood, cells, and a remarkable resistance to protein adsorption that may trigger a foreign‐body response. In this work, a novel class of phosphodiester‐based ionic hydrogels is presented which are crosslinked via a phosphodiester moiety. The material shows good compatibility with blood, supports the growth and proliferation of tissue and presents opportunities for use as a drug release matrix as shown with fluorescent model compounds. The final gel is produced via base‐induced elimination from a phosphotriester precursor, which is made by the free‐radical polymerization of a phosphotriester crosslinker. This crosslinker is easily synthesized via multigram one‐pot procedures out of common laboratory chemicals. Via the addition of various comonomers the properties of the final gel may be tuned leading to a wide range of novel applications for this exciting class of materials.     

Applications of Mitsunobu Reaction in total synthesis of natural products

The Mitsunobu Reaction allows the conversion of primary and secondary alcohols to esters, phenyl ethers, thioethers and some other compounds. The nucleophile employed should be acidic, since one of the reagents, diethylazodicarboxylate (DEAD) must be protonated during the course of the reaction, preventing from the formation of unwanted side products. In this review, we try to focus on the scope and preparative synthetic applications of Mitsunobu reaction as a key step in the total synthesis of biologically active natural products.     

A quest for stable bicyclic carbenes with one,two, and three carbenic centers at theoretical level

Structural Chemistry - We have scrutinized eighteen new derivatives of carbenes with one, two, and three carbenic centers and compared their structural and thermodynamic parameters, at...     

DFT study of the dissociative adsorption of HF on an AlN nanotube

We have investigated the adsorption of hydrogen fluoride (HF) on the AlN nanotube surface using density functional theory in terms of energetic, structural and electronic properties. By overcoming energy barriers of 27.90–52.30 kcal/mol, HF molecule is dissociated into H and F species on the tube surface and its molecular structure is not preserved after the adsorption process. Dissociation energies have been calculated to be −52.57 and −70.10 kcal/mol. The process has negligible effect on the electronic and field emission properties of the AlN nanotube. This process may increase the solubility of AlN nanotubes.     

Quantitative analysis of nicotine in several cigarette brands,available in Iran

Summary The Nicotine content of seven brands of cigarettes, currently used in Iran, namely products O, Z, S, H, T, B & A has been measured. The percent of nicotine in various products has an increasing order of O>Z>S>H>T>B>A. Product O with the lowest amount of nicotine is known to be the least popular and A&B with relative high percent ages of nicotine are known to be the most popular cigarettes. The low protein and high sugar levels of some products, which improves the taste and burning quality, also accounts for higher popularity.     

Study of mechanics of physically transient electronics: A step toward controlled transiency

Transient electronics is a class of electronic devices designed to maintain stable operation for a desired and preset amount of time; and, undergo fast and complete degradation and deconstruction once transiency is triggered. Controlled and programmed transiency in solvent‐triggered devices is strongly dependent on chemical and physical interactions between the solvent and the device, as well as those within the device itself, among its constituent components. Mechanics of transiency of prototypical transient circuits demonstrate strong dependence of the transiency characteristics on that of the substrate. In the present study, we demonstrate the control of transiency through the dissolution behavior of a substrate for the devices with electronic parts composed of colloidal units. It is observed that the physical circuit–substrate interactions are the dominating factors in defining the overall transiency behavior of the device. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016 , 54, 517–524     

Nonextensivity measure for earthquake networks

Studying earthquakes and the associated geodynamic processes based on the complex network theory enables us to learn about the universal features of the earthquake phenomenon. In addition, we can determine new indices for identification of regions geophysically. It was found that earthquake networks are scale free and its degree distribution obeys the power law. Here we claim that the q$q$-exponential function is better than power law model for fitting the degree distribution. We also study the behavior of q$q$ parameter (nonextensivity measure) with respect to resolution. It was previously asserted in Eur. Phys. J. B (2012) 85: 23; that the topological characteristics of earthquake networks are dependent on each other for large values of the resolution. A peak in the plot of q$q$ against resolution determines the beginning of the assertion range.     

Third-order nonlinear optical properties of silver nanoparticles mediated by chitosan

Silver nanoparticles in chitosan medium were prepared by the chemical reduction method. Silver nitrate and hydrazine were used as the precursor and reducing agent in the present of chitosan as a natural host polymer. The samples are characterized by UV–visible spectroscopy, X-ray diffraction (XRD) and transmission electron microscopy (TEM). The measurements of nonlinear optical properties were defined by Z-scan technique using green CW laser beam operated at 532 nm wavelengths. Thermal effect has a dominant role in the overall material nonlinearity with CW laser. It is shown that the synthesized samples have a negative nonlinear refractive index.     

Spatiotemporal and synchronous chaos in accumulated coupled map lattice

The onset of spatiotemporal chaos in coupled map lattice (CML) with a new coupling scheme called accumulated CML is studied in this paper. A rigorous proof of the existence of chaos in the sense of Li–Yorke is presented. Also the range of the coupling strength in which global synchronization can be obtained is calculated by stability analysis of the synchronized state. Finally, the positivity of Lyapunov exponents confirms the existence of chaos.