全文获取类型
收费全文 | 447篇 |
免费 | 7篇 |
国内免费 | 2篇 |
专业分类
化学 | 262篇 |
晶体学 | 38篇 |
力学 | 22篇 |
数学 | 34篇 |
物理学 | 100篇 |
出版年
2022年 | 5篇 |
2021年 | 9篇 |
2020年 | 6篇 |
2019年 | 14篇 |
2018年 | 7篇 |
2017年 | 8篇 |
2016年 | 16篇 |
2015年 | 8篇 |
2014年 | 17篇 |
2013年 | 33篇 |
2012年 | 23篇 |
2011年 | 36篇 |
2010年 | 23篇 |
2009年 | 19篇 |
2008年 | 19篇 |
2007年 | 23篇 |
2006年 | 18篇 |
2005年 | 15篇 |
2004年 | 6篇 |
2003年 | 8篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 3篇 |
1997年 | 5篇 |
1996年 | 8篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 5篇 |
1988年 | 9篇 |
1987年 | 3篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1979年 | 8篇 |
1978年 | 5篇 |
1977年 | 8篇 |
1975年 | 3篇 |
1967年 | 2篇 |
1959年 | 3篇 |
1957年 | 2篇 |
1956年 | 2篇 |
1955年 | 2篇 |
1948年 | 2篇 |
1942年 | 2篇 |
1940年 | 2篇 |
1937年 | 2篇 |
排序方式: 共有456条查询结果,搜索用时 0 毫秒
451.
Rabin Neupane Saloni Malla Mariam Sami Abou-Dahech Swapnaa Balaji Shikha Kumari Digambar Kumar Waiker N. S. Hari Narayana Moorthy Piyush Trivedi Charles R. Ashby Jr. Chandrabose Karthikeyan Amit K. Tiwari 《Molecules (Basel, Switzerland)》2021,26(15)
A novel series of 4-anilinoquinazoline analogues, DW (1–10), were evaluated for anticancer efficacy in human breast cancer (BT-20) and human colorectal cancer (CRC) cell lines (HCT116, HT29, and SW620). The compound, DW-8, had the highest anticancer efficacy and selectivity in the colorectal cancer cell lines, HCT116, HT29, and SW620, with IC50 values of 8.50 ± 2.53 µM, 5.80 ± 0.92 µM, and 6.15 ± 0.37 µM, respectively, compared to the non-cancerous colon cell line, CRL1459, with an IC50 of 14.05 ± 0.37 µM. The selectivity index of DW-8 was >2-fold in colon cancer cells incubated with vehicle. We further determined the mechanisms of cell death induced by DW-8 in SW620 CRC cancer cells. DW-8 (10 and 30 µM) induced apoptosis by (1) producing cell cycle arrest at the G2 phase; (2) activating the intrinsic apoptotic pathway, as indicated by the activation of caspase-9 and the executioner caspases-3 and 7; (3) nuclear fragmentation and (4) increasing the levels of reactive oxygen species (ROS). Overall, our results suggest that DW-8 may represent a suitable lead for developing novel compounds to treat CRC. 相似文献
452.
M. I. Ahymah Joshy K. Elayaraja R. V. Suganthi S. Narayana Kalkura 《Crystal Research and Technology》2010,45(5):551-556
Polyacrylamide hydrogel is a biomaterial and nondegradable water based polymer which is used as tissue filler. Mineralization of hydroxyapatite (HAp) in a UV polymerized acrylamide gel matrix was investigated by varying the concentration of precursors and pH in the range 8, 9 and 10. During polymerization, diammonium hydrogen phosphate ions were impregnated in the gel matrix and subsequently, immersed in the calcium nitrate solution. Thin laminated macroporous structures, embedded with nanospheres and ribbons of HAp were mineralized. The HAp was found to be oriented along c‐axis, which could lead to the preferential binding of the acidic proteins on it's surface. In addition, there was an enlargement of pore sizes with an increase in pH. The laminated structures showed resorbable nature whereas, flake like structures obtained at higher concentrations were found to be bioactive. This composite could be an alternative to the use of silicone gel, to avoid long term risk of fibrosis and migration when implanted. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
453.
Potassium dihydrogen phosphate (KDP) doped with different mole concentrations of Urea and KCl were grown using low temperature solution growth technique. X‐ray diffraction studies were carried out on the grown crystals using a Shimadzu X‐ray diffractometer with CuKD radiation. X‐ray study revealed that the structures of the doped crystals are slightly distorted compared to the pure KDP crystal. This may be attributed to strains on the lattice by the adsorption of urea and KCl. 相似文献
454.
455.
Dr. Wansang Cho Solchan Won Dr. Yoona Choi Dr. Sihyeong Yi Jong Beom Park Dr. Jun-Gyu Park Caroline E. Kim Dr. Chintam Narayana Ju Hee Kim Dr. Junhyeong Yim Dr. Young Il Choi Prof. Dong-Sup Lee Prof. Seung Bum Park 《Angewandte Chemie (International ed. in English)》2023,62(18):e202300978
Modulating target proteins via the ubiquitin-proteasome system has recently expanded the scope of pharmacological inventions. Stimulator of interferon genes (STING) is an auspicious target for immunotherapy. Seminal studies envisioned the importance of STING as well as the utility of its agonists in immunotherapy outcomes. Herein, we suggest UPPRIS (upregulation of target proteins by protein-protein interaction strategy) to pharmacologically increase cellular STING levels for improved immunotherapy. We discovered the small molecule SB24011 that inhibits STING-TRIM29 E3 ligase interaction, thus blocking TRIM29-induced degradation of STING. SB24011 enhanced STING immunity by upregulating STING protein levels, which robustly potentiated the immunotherapy efficacy of STING agonist and anti-PD-1 antibody via systemic anticancer immunity. Overall, we demonstrated that targeted protein upregulation of STING can be a promising approach for immuno-oncology. 相似文献
456.