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排序方式: 共有674条查询结果,搜索用时 269 毫秒
161.
Yan J Garzan A Narayan RS Vasileiou C Borhan B 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(46):13749-13756
In an attempt to revise the structural assignment of mucoxin, and faced with 64 diastereomeric possibilities, we resorted to the synthesis of truncated structures that contained the core stereochemical sites. Twelve stereochemical analogues were synthesized, their (1)H and (13)C NMR spectra were analyzed and four recurring stereochemical trends were distilled from the data. Applying the observed trends to the diastereomeric population pared the possible choices for the correct structure of mucoxin from 64 to 4. Synthesis of these analogues led to the identification of the correct structure of mucoxin. 相似文献
162.
In the present work, it is shown that a chameleon scalar field having a non-minimal coupling with dark matter can give rise
to a smooth transition from a decelerated to an accelerated phase of expansion for the Universe. It is surprising to note
that the coupling with the chameleon scalar field hardly affects the evolution of the dark matter sector, which still redshifts
as a
⃛. 相似文献
163.
The intramolecular aminomercuration reaction of sugar-derived beta-hydroxy-gamma-alkenylamines 8a-c undergoes 5-endo-trig cyclization in high yield. The sugar-substituted pyrrolidines thus obtained were elaborated to the synthesis of polyhydroxylated indolizidine alkaloids, namely, castanospermine 1a, 1-epi-castanospermine 1b, and 8a-epi-castanospermine 1c, having promising glycosidase inhibitory activities. 相似文献
164.
165.
Markad SD Karanjule NS Sharma T Sabharwal SG Puranik VG Dhavale DD 《Organic & biomolecular chemistry》2006,4(13):2549-2555
The Johnson-Claisen rearrangement of D-glucose-derived allylic alcohols 5a,b, afforded sugar-substituted gamma,delta-unsaturated ester in high yield. Conversion of the ester group to an azidomethyl group, epoxidation of the double bond and hydrogenation gave pyrrolidine ring skeletons 13a and 13b, which were transformed to tetrahydroxy perhydroaza-azulenes 1a and 1b, respectively. Glycosidase inhibitory activity was also evaluated. 相似文献
166.
UNSTEADY FREE CONVECTIVE MHD FLOW AND MASS TRANSFER THROUGH POROUS MEDIUM IN A ROTATING SYSTEM WITH FLUCTUATING HEAT SOURCE/SINK AND CHEMICAL REACTION 下载免费PDF全文
Rabi Narayan Barik Gouranga Charan Dash Maheswar Kar 《Journal of Applied Analysis & Computation》2014,4(3):231-244
An investigation of unsteady MHD free convective flow and mass transfer during the motion of a viscous incompressible fluid through a porous medium in the presence of heat source, bounded by an infinite vertical porous surface, in a rotating system is presented. The porous plane surface and the porous medium are assumed to rotate in a solid body rotation. The vertical surface is subject to uniform constant suction perpendicular to it and the temperature at this surface fluctuates in time about a non-zero constant mean. Analytical expressions for the velocity, temperature and concentration fields are obtained using perturbation technique. Normal 0 false false false EN-US X-NONE X-NONE 相似文献
167.
168.
Mitra RN Dasgupta A Das D Roy S Debnath S Das PK 《Langmuir : the ACS journal of surfaces and colloids》2005,21(26):12115-12123
The primary objective of the present article is to understand how the geometric constraints at the surfactant head affect the lipase activity in the reverse micellar interface. To resolve this issue, surfactants were designed and synthesized, and activity was measured in /water/isooctane/n-hexanol reverse micellar systems at z ([alcohol]/[surfactant])=5.6, pH 6.0 (20 mM phosphate), 25 degrees C across a varying range of W0 ([water]/[surfactant]) using p-nitrophenylalkanoates as the substrate. It was observed that lipase activity increases from surfactants to with the increment in surface area per molecule (Amin) because of the substitution by the bulky tert-butyl group at the polar head. However, the activity was found to be similar for despite an enhancement in the hydrophilic moieties at the interface. This unchanged lipase activity is presumably due to the comparable surface area of to originating from the rigidity at the surfactant head. Noticeably, the enzyme activity improved from with the simultaneous increment of both the hydroxyl group and the flexibility of the headgroup whereas that for increased exclusively with the flexibility of the headgroup. The common parameter in both groups of surfactants and is the flexibility of the headgroup, which possibly enhance Amin and consequently the lipase activity. Thus, the geometric constraints at the surfactant headgroup play a crucial role in modulating the lipase activity profile probably because of the variation in interfacial area. 相似文献
169.
We report the synthesis and DNA incorporation of a novel C-5 thiopropyne-substituted thymidine derivative which can be used to bring about covalent crosslinks between two noncomplementary DNA strands. This modified thymine pairs normally with adenine in duplex DNA and is shown not to be destabilizing to DNA double helices. Placement of the thiol-nucleotide near the center of opposing pyrimidine strands in pyr·pur·pyr triple helices results in crosslinking of the pyrimidine strands under aerobic conditions. Thermal melting studies at neutral pH show that such crosslinked ligands bind complementary purine strands with higher affinity than is possible with simple Watson-Crick recognition alone. In addition, we describe the construction of a triplex-forming circular oligonucleotide which contains a similar disulfide link across the center. This macrobicyclic ligand binds with extremely high affinity and sequence selectivity to a complementary purine DNA strand. The formation of crosslinks across two noncomplementary strands represents a new strategy for increasing affinity and selectivity of DNA recognition. 相似文献
170.
Dhavale DD Markad SD Karanjule NS PrakashaReddy J 《The Journal of organic chemistry》2004,69(14):4760-4766
The asymmetric dihydroxylation of a d-glucose derived alpha,beta-unsaturated ester 3 afforded syn vicinal diols in good to high diastereoselectivity. The conversion of these vicinal diols to the corresponding cyclic sulfate, regio-, stereoselective nucleophilic ring opening by sodium azide, and LAH reduction afforded amino heptitols 7a,b that were converted to azepane 1c,d and nojirimycin analogues 2c,d. 相似文献