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131.
High-Quality Protein Crystal Growth of Mouse Lipocalin-Type Prostaglandin D Synthase in Microgravity
Inaka K Takahashi S Aritake K Tsurumura T Furubayashi N Yan B Hirota E Sano S Sato M Kobayashi T Yoshimura Y Tanaka H Urade Y 《Crystal growth & design》2011,11(6):2107-2111
Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) catalyzes the isomerization of PGH(2) to PGD(2) and is involved in the regulation of pain and of nonrapid eye movement sleep and the differentiation of male genital organs and adipocytes, etc. L-PGDS is secreted into various body fluids and binds various lipophilic compounds with high affinities, acting also as an extracellular transporter. Mouse L-PGDS with a C65A mutation was previously crystallized with citrate or malonate as a precipitant, and the X-ray crystallographic structure was determined at 2.0 ? resolution. To obtain high-quality crystals, we tried, unsuccessfully, to crystallize the C65A mutant in microgravity under the same conditions used in the previous study. After further purifying the protein and changing the precipitant to polyethylene glycol (PEG) 8000, high-quality crystals were grown in microgravity. The precipitant solution was 40% (w/v) PEG 8000, 100 mM sodium chloride, and 100 mM HEPES-NaOH (pH 7.0). Crystals grew on board the International Space Station for 11 weeks in 2007, yielding single crystals of the wild-type L-PGDS and the C65A mutant, both of which diffracted at around 1.0 ? resolution. The crystal quality was markedly improved through the use of a high-viscosity precipitant solution in microgravity, in combination with the use of a highly purified protein. 相似文献
132.
Yoshinori KasaiChika Sakamoto Naoki MuroyaShin-ichiro Kato Yosuke Nakamura 《Tetrahedron letters》2011,52(5):623-625
[2]Rotaxanes, consisting of a fullerene derivative bearing an electron-donating 1,5-dialkoxynaphthalene moiety and a macrocycle containing electron-deficient naphthalenetetracarboxylic diimide moieties, were first successfully synthesized and characterized. 相似文献
133.
The reductive coupling of 1,3-dimethyluracil with benzophenone by Zn-TiCl4 in THF gave unusual two-to-one adduct and its further reduced product. The reductive coupling of 1,3-dimethyl-5-fluorouracil with benzophenone by Zn-TiCl4 also gave two-to-one adduct. 1,3-Dimethylthymine was, however, completely inert under the same conditions. 相似文献
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Naoki Tsuge 《Nonlinear Analysis: Theory, Methods & Applications》2010,73(3):779-791
We consider a one-dimensional bipolar hydrodynamic model of semiconductors. Although some results exist for the bipolar case, almost their conditions (the boundary condition, the doping profile, etc.) are far from practical application. In the present paper, under a condition appropriate for engineering, we shall prove the existence and the uniqueness of classical solutions for the stationary problem. The most difficult point is to obtain the bounded estimate and the energy estimate. 相似文献
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Megumi Kubo Takashi Kikukawa Seiji Miyauchi Akiteru Seki Masakatsu Kamiya Tomoyasu Aizawa Keiichi Kawano Naoki Kamo Makoto Demura 《Photochemistry and photobiology》2009,85(2):547-555
Halorhodopsin (HR) acts as a light‐driven chloride pump which transports a chloride ion from the extracellular (EC) to the cytoplasmic space during a photocycle reaction that includes some photointermediates initiated by illumination. To understand the chloride uptake mechanisms, we focused on a basic residue Arg123 of HR from Natronomonas pharaonis (NpHR), which is the only basic residue located in the EC half ion channel. By the measurements of the visible absorption spectra in the dark and the light‐induced inward current through the membrane, it was shown that the chloride binding and transport ability of NpHR completely disappeared by the change of arginine to glutamine. From flashphotolysis analysis, the photocycle of R123Q differed from that of wildtype NpHR completely. The response of the R123H mutant depended on pH. These facts imply that the positive charge at position 123 is essential for chloride binding in the ground state and for the chloride uptake under illumination. On the basis of the molecular structures of HR and the anion‐transportable mutants of bacteriorhodopsin, the effects of the positive charge and the conformational change of the Arg123 side chain as well as the chloride‐pumping mechanism are discussed. 相似文献
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Naoki Furutani Tetsuya Takahashi Nobushige Naito Takafumi Maruishi Yuko Yoshimura Chiaki Hasegawa Tetsu Hirosawa Mitsuru Kikuchi 《Entropy (Basel, Switzerland)》2021,23(4)
Recently, measuring the complexity of body movements during sleep has been proven as an objective biomarker of various psychiatric disorders. Although sleep problems are common in children with autism spectrum disorder (ASD) and might exacerbate ASD symptoms, their objectivity as a biomarker remains to be established. Therefore, details of body movement complexity during sleep as estimated by actigraphy were investigated in typically developing (TD) children and in children with ASD. Several complexity analyses were applied to raw and thresholded data of actigraphy from 17 TD children and 17 children with ASD. Determinism, irregularity and unpredictability, and long-range temporal correlation were examined respectively using the false nearest neighbor (FNN) algorithm, information-theoretic analyses, and detrended fluctuation analysis (DFA). Although the FNN algorithm did not reveal determinism in body movements, surrogate analyses identified the influence of nonlinear processes on the irregularity and long-range temporal correlation of body movements. Additionally, the irregularity and unpredictability of body movements measured by expanded sample entropy were significantly lower in ASD than in TD children up to two hours after sleep onset and at approximately six hours after sleep onset. This difference was found especially for the high-irregularity period. Through this study, we characterized details of the complexity of body movements during sleep and demonstrated the group difference of body movement complexity across TD children and children with ASD. Complexity analyses of body movements during sleep have provided valuable insights into sleep profiles. Body movement complexity might be useful as a biomarker for ASD. 相似文献