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排序方式: 共有371条查询结果,搜索用时 62 毫秒
121.
122.
Taku Aiga Dr. Yoshiyuki Manabe Keita Ito Tsung-Che Chang Dr. Kazuya Kabayama Shino Ohshima Prof. Yoshie Kametani Ayane Miura Hiroto Furukawa Dr. Hiroshi Inaba Prof. Kazunori Matsuura Prof. Koichi Fukase 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(40):17858-17864
Co-assembling vaccines composed of a lipidated HER2-derived antigenic CH401 peptide and either a lipophilic adjuvant, Pam3CSK4, α-GalCer, or lipid A 506, were evaluated as breast cancer vaccine candidates. This vaccine design was aimed to inherit both antigen multivalency and antigen-specific immunostimulation properties, observed in reported self-adjuvanting vaccine candidates, by using self-assembly and adjuvant-conjugated antigens. Under vaccination concentrations, respective lipophilic adjuvants underwent co-assembly with lipidated CH401, which boosted the anti-CH401 IgG and IgM production. In particular, α-GalCer was responsible for the most significant immune activation. Therefore, the newly developed vaccine design enabled the optimization of adjuvants against the antigenic CH401 peptide in a simple preparatory manner. Overall, the co-assembling vaccine design opens the door for efficient and practical self-adjuvanting vaccine development. 相似文献
123.
Takashi Ishizone Keita Kitazawa Takashi Suzuki Susumu Kawauchi 《Macromolecular Symposia》2013,323(1):86-91
Anionic polymerization of α-methylene-N-methylpyrrolidone ( MMP ) was carried out in THF at −78∼0 °C with diphenylmethylpotassium (Ph2CHK) and with diphenylmethyllithium (Ph2CHLi) in the presence of Lewis acidic diethylzinc (Et2Zn). Poly( MMP )s possessing predicted molecular weights based on the molar ratios between monomer and initiators and narrow molecular weight distributions (Mw/Mn < 1.1) were obtained in quantitative yields. It was demonstrated that the propagating chain end of poly( MMP ) was stable at −30 °C to form the polymers with well-defined chain structures. From the polymerizations at the various temperatures ranging from −50 to −30 °C, the apparent rate constant and the activation energy of the polymerization were estimated as follows: ln k = −6.93 × 103/T + 25.7 and 57 ± 5 kJ mol−1, respectively. 相似文献
124.
The effect of distributed bubble nuclei sizes on shock propagation in a bubbly liquid is numerically investigated. An ensemble-averaged technique is employed to derive the statistically averaged conservation laws for polydisperse bubbly flows. A finite-volume method is developed to solve the continuum bubbly flow equations coupled to a single-bubble-dynamic equation that incorporates the effects of heat transfer, liquid viscosity and compressibility. The one-dimensional shock computations reveal that the distribution of equilibrium bubble sizes leads to an apparent damping of the averaged shock dynamics due to phase cancellations in oscillations of the different-sized bubbles. If the distribution is sufficiently broad, the phase cancellation effect can dominate over the single-bubble-dynamic dissipation and the averaged shock profile is smoothed out. 相似文献
125.
Bunpei Hatano Tomoharu TachikawaTetsunori Mori Keita NagahashiTatsuro Kijima 《Tetrahedron letters》2011,52(27):3467-3469
The reductive coupling of aromatic N,N-acetals and N,O-acetal activated by chlorotrimethylsilane proceeded smoothly in the presence of zinc to give the corresponding diamines in good yields. 相似文献
126.
Conjugated polymers gain growing importance as conductive materials in industrial applications in various fields of electronic devices. Cellulose with its extraordinary supramolecular structure and material properties can help to awake the possibilities for conducting polymers in interplay of the two materials. The ability of additional derivatization, the stiff and oriented molecular structure and the inherent strength, stability and film-forming properties give cellulose a complementary role to the brittle conjugated polymers, cellulose imparting the features of a stable and robust carrier component. To go forward this way, making a composite out of cellulose and conducting polymers is a prerequisite. Different strategies to form composite materials of non-derivatized cellulose and conductive organic polymers were tested. Significant differences between various mixing strategies as well as between the conducting polymers polyaniline (PAni), polypyrrole (PPy), and polythiophen (PTh) were observed. In situ synthesis of the conducting polymers in cellulose solutions and microcellulose dispersions as well as blending of pre-synthesized conducting polymers in these cellulose systems were tested. Unexpectedly, not homogenous mixtures showed best results in respect to film formation and conductivity, but composites formed by heterogeneous mixtures of the conducting polymers within a cellulose gel. Best results were obtained with finely dispersed PAni. The results support development studies towards circuitry and photo-current systems based on cellulose carriers. 相似文献
127.
Keita Kanda Shusuke YamanakaTohru Saito Takashi KawakamiYasutaka Kitagawa Mitsutaka OkumuraHaruki Nakamura Kizashi Yamaguchi 《Polyhedron》2011,30(18):3256-3261
The manganese clusters have attracted much attention in relation with the oxygen evolving center (OEC) in photosystem II (PS II) system, which catalyzes the water oxidation reaction. Previously, we examined various spin-structures of Mn(II)4O4 model clusters, of which all of magnetic interactions are antiferromagnetic. In this study, we investigated electronic and magnetic structures of simple model clusters, Mn4O4(OAc)6 and Mn3CaO4(OAc)6 using spin unrestricted B3LYP (UB3LYP) method. The UB3LYP method is a standard tool for this study and has been in fact employed by many researchers. However, several peculiar features are observed for these model clusters: for instance the most stable spin state becomes the highest spin state for Mn(IV)4O4(OAc)6 although this model cluster consists of superexchange type of units, Mn(IV)2O2 that usually favors antiferromagnetic spin alignments. Implications of the comparative results are discussed in relation to the electrophilic (or radical) mechanism for the O-O bond formation in the OEC. 相似文献
128.
Hayashi K Shimanouchi T Kato K Miyazaki T Nakamura A Umakoshi H 《Colloids and surfaces. B, Biointerfaces》2011,87(1):28-35
The surface properties of Span 80 vesicles at various cholesterol contents, together with those of various liposomes, were characterized by using fluorescence probes. The membrane fluidity of the Span 80 vesicles was measured by 1,6-diphenyl-1.3.5-hexatriene (DPH) and trimethlyammonium-DPH (TMA-DPH), and the results suggested that the surface of the Span 80 vesicles was fluid due to the lateral diffusion of Span 80 molecules. The depolarization measured by TMA-DPH and the headgroup mobility measured by dielectric dispersion analysis indicated the high mobility of the head group of Span 80 vesicles. This suggested that the surface of Span 80 vesicles was flexible due to the head group structure of Span 80, sorbitol. In addition, spectrophotometric analysis with 6-dodecanoyl-N, N-dimethyl-2-naphthylamine and 8-anilino-1-naphthalenesulfonic acid indicated that the water molecules could easily invade into the interior of the Span 80 vesicle membrane, suggesting that the membrane surface was more wet than the liposome surface. These surface properties indicated that the protein could interact with the interior of vesicle membranes, which was similar to the case of cholesterol. Thus the present results confirmed that the Span 80 vesicle surfaces showed the unique characteristics of fluidity, flexibility, and "wetness", whereas the liposome surfaces did not. 相似文献
129.
Y Xiang NV Izarova F Schinle O Hampe B Keita U Kortz 《Chemical communications (Cambridge, England)》2012,48(79):9849-9851
The discrete heteropolyaurate [Au(III)(4)O(4)(Se(IV)O(3))(4)](4-) () represents only the second member of this class ever reported, and was synthesized via one-pot room temperature condensation in aqueous medium. was structurally characterized in the solid state and in solution by single-crystal XRD, TGA, FT-IR, (77)Se NMR, mass spectrometry and electrochemistry. 相似文献
130.
Hagiwara K Sei Y Akita M Yoshizawa M 《Chemical communications (Cambridge, England)》2012,48(62):7678-7680
A novel tubular macrocycle containing four anthracene panels covalently linked by meta-phenylene spacers was synthesized. The tube is approximately 1 nm long with anthracene panels delimiting a columnar cavity with a diameter of ~1 nm and exhibits strong blue fluorescence. 相似文献