Errorless and errorful learning modulated by transcranial direct current stimulation

Background

Caspase-3 is one of the most downstream enzymes activated in the apoptotic pathway. In caspase-3 deficient mice, loss of cochlear hair cells and spiral ganglion cells coincide closely with hearing loss. In contrast with the auditory system, details of the vestibular phenotype have not been characterized. Here we report the vestibular phenotype and inner ear anatomy in the caspase-3 deficient (Casp3 ^-/- ) mouse strain.

Results

Average ABR thresholds of Casp3 ^-/- mice were significantly elevated (P < 0.05) compared to Casp3 ^+/- mice and Casp3 ^+/+ mice at 3 months of age. In DPOAE testing, distortion product 2F1-F2 was significantly decreased (P < 0.05) in Casp3 ^-/- mice, whereas Casp3 ^+/- and Casp3 ^+/+ mice showed normal and comparable values to each other. Casp3 ^-/- mice were hyperactive and exhibited circling behavior when excited. In lateral canal VOR testing, Casp3 ^-/- mice had minimal response to any of the stimuli tested, whereas Casp3 ^+/- mice had an intermediate response compared to Casp3 ^+/+ mice. Inner ear anatomical and histological analysis revealed gross hypomorphism of the vestibular organs, in which the main site was the anterior semicircular canal. Hair cell numbers in the anterior- and lateral crista, and utricle were significantly smaller in Casp3 ^-/- mice whereas the Casp3 ^+/- and Casp3 ^+/+ mice had normal hair cell numbers.

Conclusions

These results indicate that caspase-3 is essential for correct functioning of the cochlea as well as normal development and function of the vestibule.     

Growth and investigation of antifungal properties of ZnO nanorod arrays on the glass

In this study, we have investigated the antifungal activity of ZnO nanorods prepared by the chemical solution method against Candida albicans. In the study, Zinc oxide nanorods have been deposited on glass substrates using the chemical solution method. The as-grown samples are characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). X-ray diffraction (XRD) showed zinc oxide nanorods grown in (0 0 2) orientation. The antifungal results indicated that ZnO nanorod arrays exhibit stable properties after two months and play an important role in the growth inhibitory of Candida albicans.     

Dust ion-acoustic shock waves due to dust charge fluctuation in a superthermal dusty plasma

The nonlinear propagation of dust ion-acoustic (DIA) shock waves is studied in a charge varying dusty plasma with electrons having kappa velocity distribution. We use hot ions with equilibrium streaming speed and a fast superthermal electron charging current derived from orbit limited motion (OLM) theory. It is found that the presence of superthermal electrons does not only significantly modify the basic properties of shock waves, but also causes the existence of shock profile with only positive potential in such plasma with parameter ranges corresponding to Saturn?s rings. It is also shown that the strength and steepness of the shock waves decrease with increase of the size of dust grains and ion temperature.     

A new multiobjective allocator of capacitor banks and distributed generations using a new investigated differential evolution

This article has investigated a new multiobjective allocation of optimal sizing and sitting of distributed generation (DG) units and capacitor banks in simultaneous mode to improve reliability and reduce energy losses. The proposed method consists of four objectives, that is, cost of energy not supplied, system average interruption duration index, costs of energy loss and investment. A novel structure differential evolution has been suggested to solve this nonlinear complex problem and its results are compared with related values of genetic algorithm and simple differential evolutionary algorithm. In addition to the novel objective function, the other contribution of this article is proposing a new model for load and energy cost. Three types of DGs, that is, wind turbine, solar cell, and diesel generator have been used in placement process. To verify the comprehensiveness of the proposed function, three scenarios have been introduced: scenario i: first, placement of DGs, then capacitor banks, scenario ii: first, placement of capacitor banks, and then DGs, and scenario iii: simultaneous placement of DGs and capacitor banks. Simulations have been carried out on one part of practical distribution network in Metropolitan Tabriz in North West of Iran. The results of simulations have been discussed and analyzed using the five novel indices. The obtained simulation results using proposed function shows that the simultaneous placement of DGs and capacitor banks results in more reduction of the energy losses and increase improvements of reliability indices as well as voltage profile. © 2013 Wiley Periodicals, Inc. Complexity 19: 40–54, 2014     

A joinings classification and a special case of Raghunathan’s conjecture in positive characteristic (with an appendix by Kevin Wortman)

We prove the classification of joinings for maximal horospherical subgroups acting on homogeneous spaces without any restriction on the characteristic. Using the linearization technique, we deduce a special case of Raghunathan’s orbit closure conjecture. In the appendix, quasi-isometries of higher rank lattices in semisimple algebraic groups over fields of positive characteristic are characterized.     

On presentations of integer polynomial points of simple groups over number fields

Let K be a number field and let A be its ring of integers. Let G be a connected, noncommutative, absolutely almost simple algebraic K-group. If the K-rank of G equals 2, then G(A[t]) is not finitely presented.     

Retention of lysozyme activity by physical immobilization in nanocellulose aerogels and antibacterial effects

Aerogels prepared from aqueous dispersions of anionic and cationic cellulose nanofibrils (CNFs) were investigated as solid supports for enzymes and silver nanoparticles and to elicit a sustained antibacterial effect. The imparted stabilization in dry conditions was studied with aerogels that were cast after mixing the enzymes with CNFs followed by dehydration (freeze-drying). The activity of lysozyme immobilized in the given CNF system was analyzed upon storage in liquid and air media. In contrast with aqueous solutions of free, unbound enzyme, which lost activity after the first day, the enzyme immobilized physically in unmodified and cationic CNF presented better stability (activity for a longer time). However, the enzyme activity was reduced in the case of anionic CNF, which was prepared by TEMPO-mediated oxidation (TO-CNF). Both humidity and temperature reduced the stability of the enzyme immobilized in the respective CNF aerogel. The antibacterial activity of CNF aerogels carrying lysozyme was also tested against gram-negative and gram-positive bacteria. The results were compared with those obtained from CNF systems loaded with silver nanoparticles (AgNP) after in situ synthesis via UV reduction. Storage in cold or dry conditions preserved the activity and antibacterial performance of enzyme-loaded CNF aerogels. As expected, the lysozyme-containing aerogels showed lower inhibition than the AgNP-containing aerogel. In this latter case, the antibacterial activity depended on the concentration and size of the nanoparticles. Compared to unmodified CNF and TO-CNF, the aerogels prepared with cationic CNF, loaded with either lysozyme or AgNPs, showed remarkably better antibacterial activity. Similar experiments were conducted with horseradish peroxidase, which confirmed, to different degrees, the observations derived from the lysozyme systems. Overall, the results indicate that non-toxic and biodegradable CNF is a suitable support for bio-active materials and is effective in protecting and retaining enzymatic and antibacterial activities.     

Template-based growth of titanium dioxide nanorods by a particulate sol-electrophoretic deposition process

TiO 2 nanorods have been successfully grown into a track-etched polycarbonate (PC) membrane by a particulate sol-electrophoretic deposition from an aqueous medium.The prepared sols had a narrow particle size distribution around 17 nm and excellent stability against aging,with zeta potentials in the range of 47-50 mV at pH 2.It was found that TiO 2 nanorods were grown from dilute aqueous sol with a low,0.1-M concentration.Fourier transform infrared spectroscopy (FT-IR) analysis confirmed that a full conversi...