全文获取类型
收费全文 | 539篇 |
免费 | 19篇 |
专业分类
化学 | 469篇 |
晶体学 | 2篇 |
力学 | 6篇 |
数学 | 12篇 |
物理学 | 69篇 |
出版年
2024年 | 1篇 |
2022年 | 22篇 |
2021年 | 40篇 |
2020年 | 11篇 |
2019年 | 26篇 |
2018年 | 29篇 |
2017年 | 24篇 |
2016年 | 20篇 |
2015年 | 29篇 |
2014年 | 16篇 |
2013年 | 36篇 |
2012年 | 34篇 |
2011年 | 35篇 |
2010年 | 26篇 |
2009年 | 21篇 |
2008年 | 17篇 |
2007年 | 19篇 |
2006年 | 20篇 |
2005年 | 18篇 |
2004年 | 14篇 |
2003年 | 13篇 |
2002年 | 8篇 |
2001年 | 8篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1985年 | 1篇 |
1983年 | 2篇 |
1982年 | 4篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 7篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1969年 | 2篇 |
1961年 | 3篇 |
1959年 | 1篇 |
排序方式: 共有558条查询结果,搜索用时 15 毫秒
451.
Yakovlev R. Yu. Osipova A. S. Solomatin A. S. Kulakova I. I. Murav’eva G. P. Avramenko N. V. Leonidov N. B. Lisichkin G. V. 《Russian Journal of General Chemistry》2015,85(6):1565-1574
Russian Journal of General Chemistry - In recent years, detonation nanodiamond is regarded as a promising material for biomedical applications. However, a significant problem that stops of... 相似文献
452.
453.
454.
Back Cover: Pyranoside‐into‐Furanoside Rearrangement: New Reaction in Carbohydrate Chemistry and Its Application in Oligosaccharide Synthesis (Chem. Eur. J. 50/2014) 下载免费PDF全文
Dr. Vadim B. Krylov Dmitry A. Argunov Dmitry Z. Vinnitskiy Stella A. Verkhnyatskaya Dr. Alexey G. Gerbst Dr. Nadezhda E. Ustyuzhanina Dr. Andrey S. Dmitrenok Prof. Dr. Johannes Huebner Prof. Dr. Otto Holst Prof. Dr. Hans‐Christian Siebert Prof. Dr. Nikolay E. Nifantiev 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(50):16780-16780
455.
456.
Nadezhda Semenova Tatyana Vadivasova Vadim Anishchenko 《The European physical journal. Special topics》2018,227(10-11):1173-1183
We study the peculiarities of the solitary state appearance in the ensemble of nonlocally coupled chaotic maps. We show that the nonlocal coupling and features of the partial elements lead to the emergence of multistability in the system. The existence of solitary state is caused by the formation of two attracting sets with different basins of attraction. Their evolution is analyzed depending on the coupling parameters. 相似文献
457.
458.
Galina F. Makhaeva Nadezhda V. Kovaleva Elena V. Rudakova Natalia P. Boltneva Sofya V. Lushchekina Irina I. Faingold Darya A. Poletaeva Yuliya V. Soldatova Raisa A. Kotelnikova Igor V. Serkov Anatoly K. Ustinov Alexey N. Proshin Eugene V. Radchenko Vladimir A. Palyulin Rudy J. Richardson 《Molecules (Basel, Switzerland)》2020,25(24)
New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers were synthesized as potential multifunctional agents for Alzheimer’s disease (AD) treatment. All compounds were potent inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with selectivity toward BChE. Lead compound 8c, 2,6-di-tert-butyl-4-{[2-(7,8,9,10- tetrahydro-6H-cyclohepta[b]quinolin-11-ylamino)-ethylimino]-methyl}-phenol exhibited an IC50(AChE) = 1.90 ± 0.16 µM, IC50(BChE) = 0.084 ± 0.008 µM, and 13.6 ± 1.2% propidium displacement at 20 μM. Compounds possessed low activity against carboxylesterase, indicating likely absence of clinically unwanted drug-drug interactions. Kinetics were consistent with mixed-type reversible inhibition of both cholinesterases. Docking indicated binding to catalytic and peripheral AChE sites; peripheral site binding along with propidium displacement suggest the potential of the hybrids to block AChE-induced β-amyloid aggregation, a disease-modifying effect. Compounds demonstrated high antioxidant activity in ABTS and FRAP assays as well as inhibition of luminol chemiluminescence and lipid peroxidation in mouse brain homogenates. Conjugates 8 with amine-containing spacers were better antioxidants than those with enamine spacers 7. Computational ADMET profiles for all compounds predicted good blood-brain barrier distribution (permeability), good intestinal absorption, and medium cardiac toxicity risk. Overall, based on their favorable pharmacological and ADMET profiles, conjugates 8 appear promising as candidates for AD therapeutics. 相似文献
459.
460.