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51.
Hany Ezzat Khalil Miada F. Abdelwahab Promise Madu Emeka Lorina I. Badger-Emeka Krishnaraj Thirugnanasambantham Hairul-Islam Mohamed Ibrahim Sara Mohamed Naguib Katsuyoshi Matsunami Nada M. Abdel-Wahab 《Molecules (Basel, Switzerland)》2022,27(9)
Diabetes mellitus (DM) is a complicated condition that is accompanied by a plethora of metabolic symptoms, including disturbed serum glucose and lipid profiles. Several herbs are reputed as traditional medicine to improve DM. The current study was designed to explore the chemical composition and possible ameliorative effects of Ocimum forskolei on blood glucose and lipid profile in high-fat diet/streptozotocin-induced diabetic rats and in 3T3-L1 cell lines as a first report of its bioactivity. Histopathological study of pancreatic and adipose tissues was performed in control and treatment groups, along with quantification of glucose and lipid profiles and the assessment of NF-κB, cleaved caspase-3, BAX, and BCL2 markers in rat pancreatic tissue. Glucose uptake, adipogenic markers, DGAT1, CEBP/α, and PPARγ levels were evaluated in the 3T3-L1 cell line. Hesperidin was isolated from total methanol extract (TME). TME and hesperidin significantly controlled the glucose and lipid profile in DM rats. Glibenclamide was used as a positive control. Histopathological assessment showed that TME and hesperidin averted necrosis and infiltration in pancreatic tissues, and led to a substantial improvement in the cellular structure of adipose tissue. TME and hesperidin distinctly diminished the mRNA and protein expression of NF-κB, cleaved caspase-3, and BAX, and increased BCL2 expression (reflecting its protective and antiapoptotic actions). Interestingly, TME and hesperidin reduced glucose uptake and oxidative lipid accumulation in the 3T3-L1 cell line. TME and hesperidin reduced DGAT1, CEBP/α, and PPARγ mRNA and protein expression in 3T3-L1 cells. Moreover, docking studies supported the results via deep interaction of hesperidin with the tested biomarkers. Taken together, the current study demonstrates Ocimum forskolei and hesperidin as possible candidates for treating diabetes mellitus. 相似文献
52.
Ahmed Z. Afify Ahmed M. Gemeay Nada M. Alfaer Gauss M. Cordeiro Eslam H. Hafez 《Entropy (Basel, Switzerland)》2022,24(7)
We introduce here a new distribution called the power-modified Kies-exponential (PMKE) distribution and derive some of its mathematical properties. Its hazard function can be bathtub-shaped, increasing, or decreasing. Its parameters are estimated by seven classical methods. Further, Bayesian estimation, under square error, general entropy, and Linex loss functions are adopted to estimate the parameters. Simulation results are provided to investigate the behavior of these estimators. The estimation methods are sorted, based on partial and overall ranks, to determine the best estimation approach for the model parameters. The proposed distribution can be used to model a real-life turbocharger dataset, as compared with 24 extensions of the exponential distribution. 相似文献
53.
Abdel Nasser B. Singab Nada M. Mostafa Iten M. Fawzy Deepika Bhatia Pooja Tanaji Suryawanshi Atul Kabra 《Molecules (Basel, Switzerland)》2022,27(19)
Maintaining healthy skin is important for a healthy body. At present, skin diseases are numerous, representing a major health problem affecting all ages from neonates to the elderly worldwide. Many people may develop diseases that affect the skin, including cancer, herpes, and cellulitis. Long-term conventional treatment creates complicated disorders in vital organs of the body. It also imposes socioeconomic burdens on patients. Natural treatment is cheap and claimed to be safe. The use of plants is as old as mankind. Many medicinal plants and their parts are frequently used to treat these diseases, and they are also suitable raw materials for the production of new synthetic agents. A review of some plant families, viz., Fabaceae, Asteraceae, Lamiaceae, etc., used in the treatment of skin diseases is provided with their most common compounds and in silico studies that summarize the recent data that have been collected in this area. 相似文献
54.
Afrah E. Mohammed Sahar S. Alghamdi Nada K. Alharbi Fatma Alshehri Rasha Saad Suliman Fahad Al-Dhabaan Maha Alharbi 《Molecules (Basel, Switzerland)》2022,27(22)
An in silico approach applying computer-simulated models helps enhance biomedicines by sightseeing the pharmacology of potential therapeutics. Currently, an in silico study combined with in vitro assays investigated the antimicrobial ability of Limoniastrum monopetalum and silver nanoparticles (AgNPs) fabricated by its aid. AgNPs mediated by L. monopetalum were characterized using FTIR, TEM, SEM, and DLS. L. monopetalum metabolites were detected by QTOF–LCMS and assessed using an in silico study for pharmacological properties. The antibacterial ability of an L. monopetalum extract and AgNPs was investigated. PASS Online predictions and the swissADME web server were used for antibacterial activity and potential molecular target metabolites, respectively. Spherical AgNPs with a 68.79 nm average size diameter were obtained. Twelve biomolecules (ferulic acid, trihydroxy-octadecenoic acid, catechin, pinoresinol, gallic acid, myricetin, 6-hydroxyluteolin, 6,7-dihydroxy-5-methoxy 7-O-β-d-glucopyranoside, methyl gallate, isorhamnetin, chlorogenic acid, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-β-l-mannopyranosyl)-β-d-glucopyranoside) were identified. The L. monopetalum extract and AgNPs displayed antibacterial effects. The computational study suggested that L. Monopetalum metabolites could hold promising antibacterial activity with minimal toxicity and an acceptable pharmaceutical profile. The in silico approach indicated that metabolites 8 and 12 have the highest antibacterial activity, and swissADME web server results suggested the CA II enzyme as a potential molecular target for both metabolites. Novel therapeutic agents could be discovered using in silico molecular target prediction combined with in vitro studies. Among L. Monopetalum metabolites, metabolite 12 could serve as a starting point for potential antibacterial treatment for several human bacterial infections. 相似文献
55.
Djaković-Sekulić Tatjana Lj. Perišić-Janjić Nada U. Petrović Slobodan D. 《平面色谱法杂志一现代薄层色谱法》2003,16(2):147-153
JPC – Journal of Planar Chromatography – Modern TLC - The chromatographic behavior of para-substituted amides of α-phenylacetic, benzoic, propanoic, and 2,2-dimethylpropanoic acid... 相似文献
56.
M. S. Abd El Halim A. Nada W. A. Gad 《Monatshefte für Chemie / Chemical Monthly》1994,125(12):1437-1442
Summary Aminolysis of 3-[2-(3,5-dimethylpyrazolyl)] succinic anhydride (1) leads to5. Hydrazine hydrate reacts with1a to give 4-(3,5-dimethylpyrazolyl)-1,2,4,5-tetrahydro-3,6-pyridazindione. The structures were confirmed by IR, MS,1H and13C NMR.
3-[2-(3,5-Dimethylpyrazolyl)]-succinanhydrid, ein Synthon für die Synthese einiger Heterocyclen mit potentieller pharmazeutisch nutzbarer Aktivität
Zusammenfassung Die Aminolyse von 3-[2-(3,5-Dimethylpyrazolyl)]-succinanhydrid (1) führt zu5. Hydrazinhydrat reagiert mit1a zu 4-(3,5-Dimethylpyrazolyl)-1,2,4,5-tetrahydro-3,6-pyridazindion. Die Strukturen wurden mittels IR, MS,1H-NMR und13C-NMR überprüft.相似文献
57.
Remo Gamboni Peter Mohr Nada Waespe-Šarčevic̀ Christoph Tamm 《Tetrahedron letters》1985,26(2):203-206
3-Phenylpropionates of chiral alcohols derived from (+)-camphor are oxidized by Mo05· Py·HMPT (MoOPH) with high diastereoselectivity. 相似文献
58.
59.
Perišić-Janjić Nada Vastag Gyöngyi Tomić Jelena Petrović Slobodan 《平面色谱法杂志一现代薄层色谱法》2007,20(5):353-359
JPC – Journal of Planar Chromatography – Modern TLC - The chromatographic behavior of some N,N-disubstituted-2-phenyl-acetamide derivatives has been studied on the chemically bonded... 相似文献
60.
Synthesis of the seco-Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor
Dr. David M. Pinkerton Dr. Sharon Chow Nada H. Eisa Kashish Kainth Timothy J. Vanden Berg Dr. Jed M. Burns Assoc. Prof. Luke W. Guddat Dr. G. Paul Savage Prof. Ahmed Chadli Prof. Craig M. Williams 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(6):1451-1455
D-Ring-seco-limonoids (tetranortriterpenoids), such as gedunin and xylogranin B display anti-cancer activity, acting via inhibition of Hsp90 and/or associated chaperon machinery (e.g., p23). Despite this, these natural products have received relatively little attention, both in terms of an enabling synthetic approach (which would allow access to derivatives), and as a consequence their structure–activity relationship (SAR). Disclosed herein is a generally applicable synthetic route to the BCD ring system of the seco-D-ring double bond containing limonoids. Furthermore, cell based assays revealed the first skeletal fragment that exhibited inhibition of the p23 enzyme at a level which was equipotent to that of gedunin, despite being much less structurally complex. 相似文献