Bioresponsive Hyaluronic Acid‐Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery

In this paper, we present a facile strategy to synthesize hyaluronic acid (HA) conjugated mesoporous silica nanoparticles (MSP) for targeted enzyme responsive drug delivery, in which the anchored HA polysaccharides not only act as capping agents but also as targeting ligands without the need of additional modification. The nanoconjugates possess many attractive features including chemical simplicity, high colloidal stability, good biocompatibility, cell‐targeting ability, and precise cargo release, making them promising agents for biomedical applications. As a proof‐of‐concept demonstration, the nanoconjugates are shown to release cargoes from the interior pores of MSPs upon HA degradation in response to hyaluronidase‐1 (Hyal‐1). Moreover, after receptor‐mediated endocytosis into cancer cells, the anchored HA was degraded into small fragments, facilitating the release of drugs to kill the cancer cells. Overall, we envision that this system might open the door to a new generation of carrier system for site‐selective, controlled‐release delivery of anticancer drugs.     

CUSUM,GLR,GEWMA以及RFCuscore控制图监测稳定过程均值漂移的效果比较(英)

本文给出了累积和控制图(CUSUM)监测稳定过程均值漂移的平均运行长度(ARL)的区间估计,并采用数字模拟的方法对CUSUM,GLR,GEWMA以及RFCuscore四种控制图监测稳定过程均值漂移的效果进行比较,结果显示CUSUM效果最好.     

两种随机存贮管理模型的建立和求解

建立了仓库容量有限条件下单品种、多品种允许缺货的随机存贮模型.采用连续的时间变量更合理地描述了问题,简化了模型的建立.模型的求解是一个以分段的平均损失费用函数作为目标的带约束最优化问题.针对题目中的具体数据对随机量送货滞后时间的密度函数进行了估计,解出了单品种、多品种条件下最优订货点的值和存贮方案.通过分情况讨论把单品种存贮模型推广为多品种(m种)存贮模型,论证了目标函数的独立变量为2m-1个,使模型更加清晰、求解方便.类比控制论中的相关理论提出了一定条件下多品种存贮的最优性原理,给出了证明,指出该原理简化模型和验证模型求解结果的作用.讨论了销售速率具有随机性时的存贮模型,实际当中调整修正订货点的方法,以及仓库最大存贮量的一种预测办法.最后指出了模型的优缺点.     

喀什石榴皮籽中单宁的提取

单宁又称鞣质,在一些植物中广泛存在,是具有重要开发利用价值的天然资源。本文对新疆喀什石榴皮籽中的单宁作了提取研究,研究结果表明:在溶剂比为1.5:1(乙醇:乙醚),回流时间为12h,溶剂用量为80mL时结果最好,产率最高.     

不同氮源及浓度对条斑紫菜叶状体生长的影响

研究硝酸钠、亚硝酸钠、硫酸铵3种氮源在N∶P=16的条件下,不同氮水平对条斑紫菜叶状体的生长影响,结果表明:在O.35mgN·L-1,以LN(硫酸氨组)生长率最高;在0.70mgN·L-1,LN组的生长率反而变为最低,而硝酸钠与亚硝酸钠接近;在2.80mg N·L-1水平下,以硝基氮处理最好,为(24.5±0.1)%,其他2种氮源之间差异不显著(p＞0.05).同时,对于条斑紫菜的生长模式拟合结果显示:紫菜增重(y)与氮变化量(x1)、PO4-P变化量(x2)及氮起始量(x3)和PO4-P起始量(x4)有显著相关性.     

Time-resolved fluoroimmunoassay for 19-nortestosterone residues in aquaculture tissues.

A competitive time-resolved fluoroimmunoassay (TR-FIA) was developed for the determination of 19-nortestosterone (17beta-NT) residues in aquaculture tissues. The limit of detection (LOD) was determined to be 0.08 ng g-1 and the limit of quantification (LOQ) was less than 0.8 ng g-1. The results obtained by the TR-FIA and ELISA showed a good correlation. The established TR-FIA was validated for the determination of incurred aquaculture tissues and confirmed by liquid chromatography tandem mass spectrometry (LC/MS/MS). This proposed technique could be applied to routine residue analysis.     

N维氢原子四类升降算子的归一化系数

计算了N(d≥2)维氢原子四类升降算子的矩阵元,得到了N维氢原子归一化系数的普适表示式.当d=2或d=3时,得到二维与三维氢原子升降算子的归一化系数.     

SYNTHESIS AND SECRETION OF HUMAN ATRIAL NATRIURETIC PEPTIDE IN Saccharomyces cerevisiae

A chemically synthesized α-hANP gene was inserted into plasmid YFD18, which was an expression-secretion vector of yeast. The recombinant then transformed in the yeast Y33. The expression level of yeast transformants was about 700 μg ANP/L detected by RIA. More than 99% of expression products were secreted in the culture medium. N-terminal analysis of purified product showed that the first 4 amino acid residues of α-hANP were deleted.     

包层泵浦技术在光纤通信中的应用

包层泵浦技术以其独特、高效的特点越来越引起人们的关注，有希望能推动光纤通信新的发展。本文详细介绍了包层泵浦技术在光纤通信中的应用，包括包层泵浦光纤放大器、包层泵浦光纤激光器以及作为光纤拉曼放大器、激光器泵源的大功率掺镱双包层激光器。并且展望了包层泵浦技术中一些关键技术的发展方向。     

冲击波极端条件下玻璃的细观结构破坏

 研究了冲击波极端条件下玻璃介质的细观结构破坏问题，指出在低于Hugoniot弹性极限的应力区内，按照细观结构损伤程度的不同，在受压玻璃介质中可以划分出两个区域，即压缩区和破坏区。以K9和ZF1玻璃为例，通过双层结构样品实验，确认了玻璃样品的表面效应（即表面原生微裂纹的扩展）是破坏区形成的第一位原因。其次，基于对破坏区内细观结构损伤和破坏特性的分析，进一步提出：由于玻璃内部散布的不均匀相与其基体介质之间的压缩率不同，冲击波压缩造成了众多的局域变形点，当表面裂纹扩展到不均匀相与基体的边界处，会出现裂纹扩展路径拐折或分叉，造成介质的分割甚至粉碎，这是破坏区生成的第二位原因。