Design,synthesis, and antibacterial studies of potent pyrazolinyltriazoles

Research on Chemical Intermediates - A library of pyrazolinyltriazole hybrids (3a–l, 4a–l) was synthesized via azide–alkyne dipolar (Huisgen) cycloaddition of azidoacetyl...     

Recent progress in insertion and cyclopropanation reactions of metal carbenoids from α-diazocarbonyl compounds

Research on Chemical Intermediates - Metal–carbenoids from α-diazocarbonyl compounds are well-known reactive intermediates with a long history of useful applications in synthetic organic...     

First synthesis of 1,3-oxaselenepanes

The first synthesis of 1,3-oxaselenepane derivatives by the reaction of aryl isoselenocyanates with 4-bromobutanol in the presence of sodium hydride in THF as a one-pot reaction is described. The Z/E isomerism for the exocyclic carbon-nitrogen double bond in the selenium heterocycles was observed for the first time.     

Synthesis and surface chemistry of nano silver particles

In this report, we present a simple wet chemical route to synthesize nano-sized silver particles, and their surface properties are discussed in detail. Silver nano particles of the size 40–80 nm are formed in the process of oxidation of glucose to gluconic acid by amine in the presence of silver nitrate, and the gluconic acid caps the nano silver particle. The presence of gluconic acid on the surface of nano silver particles was confirmed by XPS and FTIR studies. As the nano silver particle is encapsulated by gluconic acid, there was no surface oxidation, as confirmed by XPS studies. The nano silver particles have also been studied for their formation, structure, morphology and size using UV–Visible spectroscopy, XRD and SEM. Further, the antibacterial properties of these nano particles show promising results for E. Coli. The influence of the alkaline medium towards the particle size and yield was also studied by measuring the pH of the reaction for DEA, NaOH and Na₂CO₃.     

Magnesium oxide nanotubes: synthesis,characterization and application as efficient recyclable catalyst for pyrazolyl 1,4-dihydropyridine derivatives

Magnesium oxide nanotubes were prepared by electrospinning technique. The nanocatalysts have been characterized by various sophisticated techniques, including XRD, SEM, and TEM. The activities of these NT catalysts are promoting pyrazolyl 1,4-dihydropyridine syntheses have been extensively investigated. Various advantages associated with these protocols simple workup procedure, short reaction times, high yields and reusability of the catalyst.     

Volatile oil composition of Pogostemon heyneanus and comparison of its composition with patchouli oil

The volatile oil of the leaves of Pogostemon heyneanus Benth. (Lamiaceae) was analyzed by GC and GC-MS. Twenty-six components representing 96.0% of the oil were identified. The major components of the oil were acetophenone (51.0%), beta-pinene (5.3%), (E)-nerolidol (5.4%), and patchouli alcohol (14.0%). Comparison of the compositions of the oils of P. heyneanus and P. cablin (Blanco) Benth. (Patchouli oil) showed wide variation between them. Though 13 sesquiterpenes and oxygenated sesquiterpenes were detected in both oils, their concentrations in the oils differed widely. Acetophenone, benzoyl acetone and (E)-nerolidol present in the oil of P. heyneanus were not detected in patchouli oil.     

A study of host-guest complexation between amodiaquine and native cyclodextrin. Characterization in solid state and its in-vitro anticancer activity

Amodiaquine (AQ) has been used widely as an antimalarial drug. Amodiaquine is a mannich base 4-amino quinolone with a mode of action similar to that of chloroquine. The inclusion complex of AQ with β-Cyclodextrin (β-CD) in solution phase is studied from the ground and excited state with UV-Visible and fluorescence spectroscopy, respectively. A binding constant and stoichiometric ratio between AQ and β-CD are calculated by BH equation. The solid complexes are prepared by physical method (PM), kneading method (KM) and co-precipitation method (CP). The solid complex is characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and powder X-ray diffraction. The CP method gives the solid product with a better yield than that of physical mixture and KM products. The orientation and structure of the complex are proposed based on the analysis of Patch-Dock server. The anticancer activity also performed for pure AQ and their complex with β-CD. It is clearly shown that an improvement of anticancer activity of AQ while forming complex with β-CD. The solid inclusion complex behaves as the better anticancer ability than AQ alone.     

A short review on latest developments in catalytic depolymerization of Poly (ethylene terephathalate) wastes

Chemical recycling of plastic wastes is top among the effective management of the solid wastes. Particularly the post-consumer polyethylene terephthalate (PET) plastic wastes mainly generated from the disposal of beverage bottles and placed third most produced polymeric waste. However, PET wastes could be chemically recycled using several types of homo-/heterogeneous acid or base catalysts, and an effective recycling process has yet to be achieved. Therefore, the present short review is intended to display recent reports on the depolymerization of PET polymer wastes. The review aimed to cover glycolysis and aminolytic depolymerization using various catalytic systems. There is a wide spectrum of catalytic systems such as metal oxides, ionic liquids, organic bases, nanoparticles, porous materials and microwave-assisted rapid depolymerization methods have been developed toward the yield enhancement of the depolymerized products. Ideologically, the present review would benefit the researchers in familiarizing themselves with the latest developments in this field.     

Spectroscopic investigations (FTIR,UV-VIS,NMR) and DFT calculations on the molecular structure of Nω-Nitro-L-arginine

The spectroscopic properties of N_ω-nitro-l-arginine were investigated by FT-IR, UV-VIS, and ¹H NMR spectra. Geometrical parameters and energies were calculated using the density functional theory (DFT) B3LYP method with the 6-311G basis set. Geometrical optimization of the molecule has been performed, vibrational spectra have been calculated, and fundamental vibrations have been determined from the total energy distribution (TED) of the vibrational modes. The HOMO-LUMO analysis is carried out for various electric fields (0.0–0.025 A^?1). The HOMO-LUMO gap is decreased while increasing the electric field. The calculated quantum chemical parameters are calculated and correlated to the inhibition efficiency, A Mullliken population was also important for determining local reactivity by indicating reactive centers and identifying potential nucleophilic and electrophilic attack sites. Charge transfer occurs inside the compound based on the HOMO LUMO gap. Calculations of DFT were evaluated in their ability to predict inhibition efficiency.