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991.
Masami Otsuka Honoo Satake Yukio Sugiura Satoru Murakami Masakatsu ShibasakiSusumu Kobayashi 《Tetrahedron letters》1993,34(52):8497-8500
Novel ligands having symmetrized coordination environment consisting of two histidine units and a pyridine are prepared. Oxygen activating efficiency of the iron complexes of the synthetic ligands increases by introducing electron donating substituent into the pyridine ring. 相似文献
992.
Huei-Ju Liu Chia-Li Wu Toshihiro Hashimoto Yoshinori Asakawa 《Tetrahedron letters》1996,37(52):9307-9308
Nudenoic acid, a new sesquiterpene possessing a novel tricyclic skeleton, was isolated from a Taiwanese liverwort Mylia nuda. The structure of nudenoic acid was determined by spectroscopic means and X-ray analysis. 相似文献
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997.
T Fujiyoshi H Iida M Murakami M Kuwashima T Uematsu 《Chemical & pharmaceutical bulletin》1989,37(3):775-777
The analgesic mechanism of (+/-)-2-[p-[(2-methylallyl)amino]phenyl]propionic acid (EB-382), a new non-steroidal antiinflammatory agent, was studied. EB-382 exerted a potent analgesic effect on yeast-induced hyperalgesia in rats and bradykinin-induced writhing in mice, and its potency was superior to that of ibuprofen. EB-382 had a comparatively weak inhibitory effect on the prostaglandin E2 production from arachidonic acid in sheep seminal vesicle microsomal fraction in vitro. EB-382 exhibited a dose-dependent inhibitory effect on the phospholipase A2 activity in 3T3 mouse fibroblast cells with a different mechanism from steroidal agents, although indomethacin and ibuprofen did not reveal any significant inhibition. EB-382 did not affect the bradykinin-induced contraction of isolated rat uterus. Intracisternal injection of EB-382 did not affect the acetic acid-induced writhing response in mice. From these results, it is suggested that the analgesic effect of EB-382 in inflammation is exerted through its direct peripheral action, and inhibition of prostaglandin biosynthesis via phospholipase A2, rather than cyclooxygenase. 相似文献
998.
T Murakami T Fukuda T Umemoto I Muro Y Miyakubo Y Nitta M Matsumae M Ide Y Suzuki T Tamegai 《Radioisotopes》1986,35(1):20-23
Using cadmium telluride (CdTe) as a detector, we assembled a computerized single probe system. The size of the CdTe used is 16 mm in diameter and 2 mm in thickness. Two types of the straight bore collimators of 16 mm in diameter were prepared. One is 16 mm in length (long type) and the other is 5 mm in length (short type). The response curves of the long and short type collimators to 57Co in water showed that the points at 10% of maximum counts were 4 cm and 3 cm in depth along the center axis. The data were accumulated by using a commercialized single cardiac probe system (OMNISCOPE) and processed by itself or transferred to the microcomputer (LSI-11/23) for further analysis. Twenty percent count loss occurred at 100 000 cps with an integral discriminator setting. This system was applied for cerebrospinal fluid (CSF) shunt flow evaluation and measurement of left ventricular ejection fraction (LVEF). Measurement of CSF shunt flow has been able to do in any patient's positioning. In 21 patients with various heart diseases, LVEFs obtained by CdTe detector were compared with those obtained by scintillation detector. There was good correlation between the LVEFs obtained by these two detectors: correlation coefficient (r)=0.939. 相似文献
999.
Tatsuo Yamauchi Koichi Kashiwada Koji Murakami 《Journal of colloid and interface science》1993,160(2)
The electric conductivity of wet pulp webs was measured at various water contents, after the water was replaced with KCl solutions of various concentrations. A specific KCl concentration in the wet pulp web equivalent to the total amount of electrolytes and dissociative groups that existed originally in the wet pulp fibers was determined from the linear relationship between the electric conductivity and the concentration of KCl added. Molar conductivity of the KCl in the wet pulp web is lower than that of the KCl solution. The amount of nonconductive water (Wnon) was estimated from the difference in molar conductivity between the wet pulp web and the KCl solution. Wnon is a kind of bound water and increases with degree of beating of the pulp. 相似文献
1000.