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991.
Muhammad Ajaz Hussain Anqa Zarish Khawar Abbas Muhammad Sher Muhammad Nawaz Tahir Wolfgang Tremel Muhammad Amin Abdul Ghafoor Bilal Ahmad Lodhi 《Cellulose (London, England)》2013,20(2):717-725
This article presents synthesis of novel macromolecular prodrugs of aceclofenac (an anti-inflammatory drug) onto hydroxypropylcellulose (HPC). The HPC-aceclofenac conjugates were prepared using an acylating agent 1,1′-carbonyldiimidazole (CDI) under homogenous reaction conditions. Aceclofenac was first activated by using CDI to form its N-acylimidazole. The N-acylimidazole of aceclofenac was then reacted with HPC polymer at 80 °C for 24 h. Highly pure prodrugs of aceclofenac were synthesized with a wide range of moderate to high degree of substitution (DS 0.41–2.12) as calculated by 1H NMR spectroscopy. The UV spectroscopic analysis has also revealed that the active drug aceclofenac was found in different conjugates from 28 to 67 mg/100 mg of HPC-aceclofenac conjugates which are in good agreement with DS calculated by 1H NMR spectroscopy. The gel permeation chromatography showed unimodal absorption that indicates no significant degradation in polymer chains during the reaction. The macromolecular prodrugs of aceclofenac were characterized using different spectroscopic and chromatographic techniques. The thermal analysis has revealed that HPC-aceclofenac conjugates (prodrugs) are 92 and 96 °C more stable than pure aceclofenac regarding their initial (Tdi) and maximum degradation temperatures (Tdm), respectively. The activation energy (Ea) and frequency factor (Z) of the degradation reactions were evaluated using Friedman, Broido and Chang methods. Degradation followed first order (n) kinetics. Transmission electron microscopy has revealed the formation of sponge like nano aggregates with population size distribution of around 80–150 nm. 相似文献
992.
Aqib Zahoor Afsar Khan Viqar U. Ahmad Amir Ahmed Saleha S. Khan Muhammad I. Ali 《Helvetica chimica acta》2012,95(9):1613-1622
The AcOEt‐soluble part of a MeOH extract from the whole plant of Erigeron bonariensis yielded two new rare‐class octulosonic acid derivatives, rel‐methyl (1R,2S,3S,5R)‐3‐(trans‐caffeoyloxy)‐7‐[(trans‐caffeoyloxy)methyl]‐2‐hydroxy‐6,8‐dioxabicyclo[3.2.1]octane‐5‐carboxylate ( 1 ) and 5,8‐di[O‐trans‐caffeoyl]‐3‐deoxy‐β‐D ‐gluco‐oct‐2‐ulopyranosonosyl 4,8‐di[O‐trans‐caffeoyl]‐3‐deoxy‐β‐D ‐gluco‐oct‐2‐ulopyranosidonic acid ( 2 ) along with a cyclohexanecarboxylic acid derivative, (1α,3β,4β,5β)‐1,4‐di‐3,5‐dihydroxy‐bis(trans‐caffeoyloxy)cyclohexanecarboxylic acid ( 3 ). The structures of these compounds were elucidated through ESI‐MS, and 1D‐ and 2D‐NMR spectroscopic techniques including 1H‐ and 13C‐NMR, HMQC or HSQC, and HMBC experiments. 相似文献
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We consider an opto-mechanical cavity system consisting of Bose-Einstein condensate (BEC), trapped inside the optical cavity and driven by single mode laser field. The intracavity field acts as nonlinear spring which couples the condensate mode with moving end mirror of the cavity. We study the occurrence of normal mode splitting in the position spectra of the mechanical oscillator and condensate mode as a consequence of hybridization of the fluctuations of intracavity field, mechanical mode and condensate mode. We also discuss the modification in the dynamics of the mechanical oscillator due to frequency of the collective oscillations of cold atoms and the back action of the atoms on the mechanical mirror. Moreover, we investigate the normal mode splitting in the transmission spectrum of cavity field. 相似文献
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This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields. 相似文献
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W. A. Farooq S. Mansoor Ali J. Muhammad S. Danish Ali M. Atif 《Optics and Spectroscopy》2014,116(3):473-478
The effects of laser irradiation on the surface, structure and optical properties of SnO thin films deposited on glass substrates using electron beam evaporation, are investigated. The thin film samples are irradiated using fundamental beam at 1064 nm from Q-switched Nd:YAG pulsed laser with different power densities. Structural morphology of the film is investigated using XRD patterns and AFM image. Both XRD pattern and AFM image show increase in grain size of the film with increasing laser power density. Other optical phenomena, photoluminescence emission, transmission, refractive index determination and optical band gaps calculations are also carried out at various laser power densities. Results from all these investigations reveal expansion in grain size of the crystalline SnO thin film with increasing laser power density. 相似文献